Javier Nieto
A5034938890- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Clinical Laboratory Practices and Quality Control
- Heart Failure Treatment and Management
- Insect symbiosis and bacterial influences
- Cardiac Valve Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Systemic Lupus Erythematosus Research
- Parasite Biology and Host Interactions
- Parathyroid Disorders and Treatments
- Peripheral Artery Disease Management
- Immunodeficiency and Autoimmune Disorders
- Enterobacteriaceae and Cronobacter Research
- Atherosclerosis and Cardiovascular Diseases
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Infectious Aortic and Vascular Conditions
- Parasitic Diseases Research and Treatment
- Sleep and related disorders
- Autoimmune and Inflammatory Disorders Research
Instituto de Salud Carlos III
2009-2024
Association of Organ Procurement Organizations
2023-2024
Centro Nacional de Microbiologia
2006-2024
Hospital Universitari de Girona Doctor Josep Trueta
2019-2024
Clínica Girona
2023-2024
Bellvitge University Hospital
2024
Oregon State University
2024
University of Girona
2021-2024
Hospital Juan Ramón Jiménez
2023
Centro de Investigación Biomédica en Red
2022
White matter lesions (WMLs) detected by cerebral magnetic resonance imaging (MRI) are putatively a consequence of hypoperfusion or ischemia. We investigated the prevalence, severity and correlates WMLs in population-based sample 1,920 African-American European-American men women aged 55-72 years, during second follow-up examination Atherosclerosis Risk Communities Study. The spin density images from 1.5-tesla MRI scans were used to define using 0-9 scale with 0 for normal 9 most severe WMLs....
Six naturally infected dogs [two with no signs of leishmaniasis ('asymptomatic'), two a few ('oligosymptomatic') and many ('polysymptomatic')] were studied before after chemotherapy. Another two, non-infected kept as controls. The clinically, haematologically parasitologically five times over 11 months their infectivity to sandflies was evaluated the treatment. 'asymptomatic' infective 'symptomatic' treatment but all un-infective for at least following Treatment led temporary improvement in...
Background and objectives Vascular calcification (VC) is common in CKD, but little known about its prognostic effect on patients with nondialysis CKD. The prevalence of VC ability to predict death, time hospitalization, renal progression were assessed. Design, setting, participants, & measurements Study Mineral Bone Disorders CKD Spain a prospective, observational, 3-year follow-up study 742 stages 3–5 from 39 centers April May 2009. was assessed using Adragao (AS; x-ray pelvis hands)...
Little information is available on malnutrition-related factors among school-aged children ≥5 years in Ethiopia. This study describes the prevalence of stunting and thinness their related Libo Kemkem Fogera, Amhara Regional State assesses differences between urban rural areas.In this cross-sectional study, anthropometrics individual household characteristics data were collected from 886 children. Height-for-age z-score for body-mass-index-for-age computed. Dietary through a 24-hour recall....
Abstract Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability 209 MDR strains ( Escherichia coli n = 106, Klebsiella pneumoniae 78, and Enterobacter spp. 25) isolated from rectal swabs in first 48 hours before or after kidney (93 patients), liver (60 patients) kidney/pancreas transplants (5 were evaluated using a microplate assay. Thirty-nine 170 post-transplant. Overall,...
Several aspects of the occurrence and management mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied. To determine incidence factors associated MA presence rupture to assess evolution those initially unruptured MA. Prospective multicenter cohort including all definite IE between January 2008 December 2020. Of 4548 cases, 85 (1.9%) developed Forty-six (54.1%) had intracranial 39 (45.9%) extracranial Rupture occurred (45.9%). Patients ruptured higher 1-year...
ABSTRACT New techniques are available for diagnosing leishmaniasis, but their efficacy in the identification of pediatric visceral leishmaniasis (VL) has not been compared with that traditional methods. Blood, bone marrow, and urine samples were taken from 25 children VL during first clinical episode, 22 days after start treatment liposomal amphotericin B (3 mg/kg/day on 6 over a 10-day period), when relapse was suspected follow-up. The results obtained suggest antibody detection techniques,...
Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where inappropriate immune response not only responsible for permitting this intracellular parasite to multiply, but also several of the pathological processes seen in disease. Effective canine vaccines are therefore a highly desirable prevention tool. In randomised, double-blinded, controlled trial, efficacy LiESP/QA-21 vaccine (CaniLeish, Virbac, France) was assessed exposing 90 naïve...
Abstract Background Outpatient parenteral antibiotic treatment (OPAT) has proven efficacious for treating infective endocarditis (IE). However, the 2001 Infectious Diseases Society of America (IDSA) criteria OPAT in IE are very restrictive. We aimed to compare outcomes with those hospital-based (HBAT). Methods Retrospective analysis data from a multicenter, prospective cohort study 2000 consecutive patients 25 Spanish hospitals (2008–2012) was performed. Results A total 429 (21.5%) received...
Background Visceral leishmaniasis (VL), the most severe form of leishmaniasis, is endemic in Europe with Mediterranean countries reporting status alongside a worrying northward spread. Serological diagnosis, including immunochromatographic test based on recombinant antigen rK39 (rK39-ICT) and direct agglutination (DAT) whole parasite antigen, have been validated regions high VL burden, such as eastern Africa Indian subcontinent. To date, no studies using large set patients performed an...
In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) and 9 (60%) (P = 0.099). When all treated lesions included, the final 279,398-treated again 87%, but Alone-treated 8 (53.3%; P 0.046). Both creams...
Left ventricular dysfunction in potential donors meeting brain death criteria often results nonuse of donor hearts for transplantation, yet little is known about its incidence or pathophysiology. Resolving these unknowns was a primary aim the DHS (Donor Heart Study), multisite prospective cohort study.
The protective capabilities of three Leishmania recombinant proteins – histone 1 (H1) and hydrophilic acylated surface protein B1 (HASPB1) immunized singly, or together as a cocktail vaccine with Montanide™, the polyprotein MML MPL®-SE adjuvant were assessed in beagle dogs. Clinical examination dogs was carried out periodically under blinded conditions condition defined asymptomatic symptomatic. At end trial, we able to confirm that following infection L. infantum promastigotes, five eight...
An increasing number of reports are calling our attention to the worldwide spread leishmaniasis. The urbanization zoonotic visceral leishmaniasis (VL) has been observed in different South American countries, due changes demographic and ecological factors. In May 2006, VL was detected for first time city Posadas (Misiones, Argentina). This event encouraged us conduct a clinical parasitological pilot survey on domestic dogs from identify their potential role as reservoirs disease. One hundred...
We assessed the performance characteristics of two rK39 immunochromatographic tests, a direct agglutination test (DAT), and an indirect immunofluorescent antibody (IFAT) in site new epidemic visceral leishmaniasis (VL) northwestern Ethiopia. The study population was composed 179 patients with suspected VL 67 controls. sensitivities Kalazar Detect ® , DiaMed-IT Leish DAT, IFAT 35 polymerase chain reaction–confirmed cases were 94.3%, 91.4%, 100%, respectively, specificities 98.5%, 94%,...
Background In northern Ethiopia the prevalence of visceral leishmaniasis is steadily rising posing an increasing public health concern. order to develop effective control strategies on transmission disease it important generate knowledge epidemiological determinants infection. Methodology/Principal Findings We conducted a cross-sectional survey children 4–15 years age using multi staged stratified cluster sampling high incidence sub-districts Amhara regional state, Ethiopia. The included...
In areas where visceral leishmaniasis is anthroponotic, asymptomatically infected patients may play a role in transmission. Additionally, the number of asymptomatic disease-endemic area will also provide information on transmission dynamics. Libo Kemkem and Fogera districts (Amhara State, Ethiopia) are now considered newly established to which endemic. selected villages these districts, we conducted study assess usefulness different approaches estimate infection rate. Of 605 participants,...
Objective. To analyze the prevalence of peripheral arterial disease (PAD) and cardiovascular (CV) risk factors in a cohort patients with systemic lupus erythematosus (SLE) to identify variables potentially related PAD. Methods. The study included 216 SLE from Lupus-Cruces prospective observational cohort. ankle brachial index (ABI) was determined each patient, values < 0.9 considered diagnostic Demographic clinical variables, presence traditional CV events, calculated by Systematic...