A5024989885- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Parasites and Host Interactions
- Viral gastroenteritis research and epidemiology
- Emergency and Acute Care Studies
- Mosquito-borne diseases and control
- Helminth infection and control
- Immune Response and Inflammation
- Viral Infections and Vectors
- Respiratory Support and Mechanisms
- Bacterial Infections and Vaccines
- Parasite Biology and Host Interactions
- Streptococcal Infections and Treatments
- Syphilis Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Reproductive tract infections research
- Cystic Fibrosis Research Advances
- Global Maternal and Child Health
- Travel-related health issues
- Malaria Research and Control
- Inhalation and Respiratory Drug Delivery
- Immunodeficiency and Autoimmune Disorders
Sanofi (France)
2020-2025
Sanofi (Germany)
2021-2025
World Health Organization
2016-2023
Diakonissenkrankenhaus
2021
German Center for Lung Research
2021
Institute of Virology of the Slovak Academy of Sciences
2021
University Medical Center Freiburg
2021
University of Freiburg
2021
Medizinische Hochschule Hannover
2021
Klinikum Oldenburg
2021
The safety of the monoclonal antibody nirsevimab and effect on hospitalizations for respiratory syncytial virus (RSV)–associated lower tract infection when administered in healthy infants are unclear. Download a PDF Research Summary. In pragmatic trial, we randomly assigned, 1:1 ratio, who were 12 months age or younger, had been born at gestational least 29 weeks, entering their first RSV season France, Germany, United Kingdom to receive either single intramuscular injection standard care...
Abstract Background No overall estimate of respiratory syncytial virus (RSV)-associated hospitalizations in children aged under 5 years has been published for the European Union (EU). We aimed to RSV hospitalization burden EU countries and Norway, by age group. Methods collated national RSV-associated estimates calculated using linear regression models via RESCEU project Denmark, England, Finland, Netherlands, Scotland, 2006–2018. Additional were obtained from a systematic review. Using...
Abstract Background Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in adults that can result hospitalizations. Estimating RSV-associated hospitalization critical for planning RSV-related healthcare across Europe. Methods We gathered estimates from the RSV Consortium Europe (RESCEU) Denmark, England, Finland, Norway, Netherlands, and Scotland 2006 to 2017. extrapolated these 28 European Union (EU) countries using nearest-neighbor matching, multiple...
The immunological and protective role of pneumococcal carriage in healthy adults is not known, but high rates disease death the elderly are associated with low prevalence.We employed an experimental human model to investigate immunizing effect a single episode.Seventy were challenged, those carriage, 10 rechallenged intranasally live 6B Streptococcus pneumoniae up 11 months after clearance first episode. Serum nasal wash antibody responses measured before each challenge.A total 29 subjects...
Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with 30-fold increase in the number of cases reported since 1960. The economic cost illness measured billions dollars annually. Environmental change and unplanned urbanization are conspiring to raise health even further beyond reach systems households. health-sector response has depended large part on control Aedes aegypti Ae. albopictus (mosquito) vectors. cost-effectiveness first-ever dengue vaccine remains be evaluated...
The polysaccharide capsule of Streptococcus pneumoniae defines over ninety serotypes, which differ in their carriage prevalence and invasiveness for poorly understood reasons. Recently, an inverse correlation between oligosaccharide structure a given has been described. Our previous work suggested link serotype growth vitro. Here we investigate whether production interferes with vitro this predicts vivo. Eighty-one switch mutants were constructed representing nine different five low (4, 7F,...
Respiratory syncytial virus (RSV) infections are one of the leading causes lower respiratory tract and have a major burden on society. For prevention control to be deployed effectively, an improved understanding seasonality RSV is necessary.The main objective this study was contribute better by examining GERi multi-country surveillance dataset.RSV seasons were included in analysis if they contained ≥100 cases. Seasonality determined using "average annual percentage" method. Analyses...
Abstract Background Respiratory syncytial virus (RSV) is one of the leading causes acute respiratory tract infections. To optimize control strategies, a better understanding global epidemiology RSV critical. this end, we initiated Global Epidemiology in Hospitalized and Community care study (GERi). Methods Focal points from 44 countries were approached to join GERi share detailed surveillance data. Countries completed questionnaire on characteristics their system. Results Fifteen provided...
Abstract Background Knowledge on age-specific hospitalizations associated with RSV infection is limited due to testing, especially in older children and adults whom infections are not expected be severe. Burden estimates based coding of hospital admissions known underestimate the burden RSV. We aimed provide robust reliable RSV-associated data respiratory from national health registers laboratory-confirmed cases Methods conducted multiseason regression analysis weekly influenza as...
Abstract Respiratory syncytial virus (RSV) infection is a major cause of morbidity in children. However, its disease burden remains poorly understood, particularly outside the hospital setting. Our study aimed to estimate medically attended acute lower respiratory (ALRI) cases potentially related RSV Spanish Longitudinal data from September 2017 June 2018 51,292 children aged < 5 years old National Healthcare System (NHS) two regions were used. Three case definitions considered: (a)...
Abstract Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in children, causing frequent outpatient visits and hospitalizations. Our study aimed to describe the clinical direct economic burden ALRI hospitalizations related RSV children Spain characteristics patients their episodes. In this retrospective study, aged < 5 years for 2015–2018 were reviewed using anonymized administrative public hospital discharge data from Spain. Three case...
Pneumococcal carriage is both immunising and a pre-requisite for mucosal systemic disease. Murine models of pneumococcal colonisation show that IL-17A-secreting CD4+ T-cells (Th-17 cells) are essential clearance pneumococci from the nasopharynx. Pneumococcal-responding have not been described in adult human lung it unknown whether they can be elicited by protect infection. We investigated direct effect experimental nasal (EHPC) on frequency phenotype cognate broncho-alveolar lavage blood...
<h3>Background</h3> The Sahel region of West Africa has the highest bacterial meningitis attack and case fatality rate in world. effect climatic factors on patterns invasive respiratory disease is not well documented. <h3>Objective</h3> We aimed to assess link between occurrence a Niger. <h3>Methods</h3> conducted daily surveillance monitoring over an 8-year period January 1, 2003, December 31, 2010, Niamey, Niger, determine risk for disease. investigated mechanistic effects these...
A simplified grading system for trachoma was published by the World Health Organization (WHO) in 1987.Intended use non-specialist personnel working at community level, includes five signs, each of which can be present or absent any eye: (i) trachomatous trichiasis; (ii) corneal opacity; (iii) inflammation-follicular; (iv) inflammation-intense; and (v) scarring.Though neither perfectly sensitive nor specific trachoma, these signs have been essential tools identifying populations that need...
Abstract Background Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden. Methods We explored routinely collected hospital data on children aged &lt; 5 years 7 European countries. compare RSV-associated admission rates, age, seasonality, time trends between Results found similar age distributions admissions each country, with the highest burden 1 old peak at...
Background There is currently no standardised approach to estimate respiratory syncytial virus (RSV) epidemics’ timing (or seasonality), a critical information for their effective prevention and control. Aim We aimed provide an overview of methods define RSV seasonality identify factors supporting method choice or interpretation/comparison seasonal estimates. Methods systematically searched PubMed Embase (2016–2021) studies using quantitative approaches determine the start end epidemics....
Neutrophils and T cells play an important role in host protection against pulmonary infection caused by Streptococcus pneumoniae. However, the of integrins recruitment these to infected lungs is not well understood. In this study we used twin approaches mAb blockade gene-deficient mice investigate relative impact specific on cellular bacterial loads following pneumococcal infection. We find that both Mac-1 (CD11b/CD18) α(4)β(1) (CD49d/CD29) integrins, but surprisingly LFA-1 (CD11a/CD18),...
Background Visceral leishmaniasis (VL), the most severe form of leishmaniasis, is endemic in Europe with Mediterranean countries reporting status alongside a worrying northward spread. Serological diagnosis, including immunochromatographic test based on recombinant antigen rK39 (rK39-ICT) and direct agglutination (DAT) whole parasite antigen, have been validated regions high VL burden, such as eastern Africa Indian subcontinent. To date, no studies using large set patients performed an...
Bronchiolitis is the most common lower respiratory tract infection (LRTI) in children and mainly caused by Respiratory Syncytial Virus (RSV). presents seasonally lasts about five months, usually between October to March, with peaks of hospitalizations December February, Northern Hemisphere. The burden bronchiolitis RSV primary care not well understood.This retrospective analysis used data from Pedianet, a comprehensive paediatric database 161 family paediatricians Italy. We evaluated...
Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial redox-driven proton pump that couples the production of NADPH to metabolic rate. In this study, we demonstrated for first time NNT has significant effect in modulation immune response and host defense against pathogens. We found mRNA enriched system-related tissues regulated during macrophage activation. Overexpression cell-line resulted decreased levels reactive oxygen species (ROS) nitric oxide upon induction inflammatory...