A5079416691- Pneumonia and Respiratory Infections
- Computer Graphics and Visualization Techniques
- Sarcoma Diagnosis and Treatment
- Respiratory viral infections research
- Neurogenesis and neuroplasticity mechanisms
- Soft tissue tumor case studies
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Parallel Computing and Optimization Techniques
- COVID-19 Clinical Research Studies
- 3D Shape Modeling and Analysis
- AI in cancer detection
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Poxvirus research and outbreaks
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Kawasaki Disease and Coronary Complications
- Tuberculosis Research and Epidemiology
- Bacillus and Francisella bacterial research
- Child and Adolescent Health
- Nerve injury and regeneration
- Metabolism and Genetic Disorders
Evelina London Children's Healthcare
2021-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2025
Institut Mondor de Recherche Biomédicale
2025
Université Paris-Est Créteil
2025
Hebrew University of Jerusalem
2023-2025
King's College London
2000-2025
Hôpital Intercommunal de Créteil
2025
Hadassah Medical Center
2023-2025
Association Française de Pédiatrie Ambulatoire
2024
St Thomas' Hospital
2023-2024
We have examined the consequences of surface interactions with glial and nonglial cells on in vitro growth CNS neurons. When cerebellar or spinal cord were plated onto monolayers highly enriched cortical astrocytes sciatic nerve Schwann cells, neurons generally grew as single showed relatively little tendency to aggregate. Similarly, neurites fasciculate. In contrast, when fibroblast, heart muscle-fibroblast, astrocyte-free meningeal monolayers, rapidly aggregated, neurite outgrowth was...
The Streptococcus pneumoniae capsule is vital for virulence and may inhibit complement activity phagocytosis. However, there are only limited data on the mechanisms by which affects consequences S. interactions with phagocytes. Using unencapsulated serotype 2 4 mutants, we have confirmed that has several effects activity. impaired bacterial opsonization C3b/iC3b both alternative classical pathways also inhibited conversion of C3b bound to surface iC3b. There was increased binding pathway...
It is not fully understood why COVID-19 typically milder in children
In this paper we report state-of-the-art results on LibriSpeech among end-to-end speech recognition models without any external training data.Our model, Jasper, uses only 1D convolutions, batch normalization, ReLU, dropout, and residual connections.To improve training, further introduce a new layer-wise optimizer called NovoGrad.Through experiments, demonstrate that the proposed deep architecture performs as well or better than more complex choices.Our deepest Jasper variant 54 convolutional...
NeMo (Neural Modules) is a Python framework-agnostic toolkit for creating AI applications through re-usability, abstraction, and composition. built around neural modules, conceptual blocks of networks that take typed inputs produce outputs. Such modules typically represent data layers, encoders, decoders, language models, loss functions, or methods combining activations. makes it easy to combine re-use these building while providing level semantic correctness checking via its type system....
The safety of the monoclonal antibody nirsevimab and effect on hospitalizations for respiratory syncytial virus (RSV)–associated lower tract infection when administered in healthy infants are unclear. Download a PDF Research Summary. In pragmatic trial, we randomly assigned, 1:1 ratio, who were 12 months age or younger, had been born at gestational least 29 weeks, entering their first RSV season France, Germany, United Kingdom to receive either single intramuscular injection standard care...
An outbreak of acute hepatitis unknown aetiology in children was reported Scotland1 April 2022 and has now been identified 35 countries2. Several recent studies have suggested an association with human adenovirus this outbreak, a virus not commonly associated hepatitis. Here we report detailed case–control investigation find between adeno-associated 2 (AAV2) infection host genetics disease susceptibility. Using next-generation sequencing, PCR reverse transcription, serology situ...
Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections aged 0-16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23-.50]) during prevaccine Delta, 66% (RR, 0.44 CI, .28-.69]) postvaccine and 95% 0.05 .02-.10]) Omicron period.
We study the performance of three parallel algorithms and their hybrid variants for solving tridiagonal linear systems on a GPU: cyclic reduction (CR), (PCR) recursive doubling (RD). develop an approach to measure, analyze, optimize GPU programs in terms memory access, computation, control overhead. find that CR enjoys algorithm complexity but suffers from more algorithmic steps bank conflicts, while PCR RD have fewer do work each step. To combine benefits basic algorithms, we propose CR+PCR...
Lethal necrotizing fasciitis caused by Streptococcus pyogenes is characterized a paucity of neutrophils at the site infection. Interleukin (IL)–8, which important for neutrophil transmigration and activation, can be degraded S. pyogenes. Blood isolates were better able to degrade human IL-8 than throat isolates. Degradation was result single specific cleavage between 59glutamine 60arginine within C-terminal α helix. Cleaved reduced activation migration. IL-8–cleaving activity found in...
We have developed an apparatus which enables us to perform accurate measurements of the shear viscosity low ionic strength, dilute polyelectrolyte solutions, down polymer concentrations below one part per million. shown that a theoretical expression for such solutions can be derived using mode–mode coupling approximation hydrodynamics charged Brownian spheres. Very good agreement between predicted and observed salt concentration molecular weight dependence is in low-added salt, solution...
Epidemiological studies of statins have suggested a link between statin therapy and decreased risk sepsis. It has been proposed that the mechanism underlying this apparent protective effect relates to their known immunomodulatory anti-inflammatory effects. The aim study was explore antimicrobial statins. Simvastatin (Merck) fluvastatin (Novartis) were both tested against six each methicillin-susceptible -resistant Staphylococcus aureus (MSSA + MRSA), vancomycin-sensitive enterococci (VSE...
Streptococcus pneumoniae is a common cause of pneumonia and infective exacerbations chronic lung disease, yet there are few data on how adaptive immunity can specifically prevent S. infection. We have used murine model nasopharyngeal colonization by the serotype 19F strain EF3030 followed infection to investigate whether protects against subsequent mechanisms involved. induced systemic local immunoglobulin G limited number protein antigens rather than capsular polysaccharide. During...
The solution of large sparse linear systems arises in many applications, such as computational fluid dynamics and oil reservoir simulation. In realistic cases the matrices are often so that they require scale distributed parallel computing to obtain interest a reasonable time. this paper we discuss design implementation AmgX library, which provides drop-in GPU acceleration algebraic multigrid (AMG) preconditioned iterative methods. library implements both classical aggregation-based AMG...
Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be dependent on anti-capsular antibody. However nasopharyngeal colonisation by Streptococcus pneumoniae also induces antibody protein antigens that could protective. We have used human intravenous immunoglobulin preparation (IVIG), representing natural IgG responses S. pneumoniae, identify the classes of are functionally relevant for IPD. in IVIG recognised capsular antigen and multiple antigens, with...
We propose NovoGrad, an adaptive stochastic gradient descent method with layer-wise normalization and decoupled weight decay. In our experiments on neural networks for image classification, speech recognition, machine translation, language modeling, it performs par or better than well tuned SGD momentum Adam AdamW. Additionally, NovoGrad (1) is robust to the choice of learning rate initialization, (2) works in a large batch setting, (3) has two times smaller memory footprint Adam.
Background The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) comprises 6 categories used the diagnosis of thyroid fine‐needle aspiration biopsy (FNAB). Each category has an associated risk malignancy, which is important in management a nodule. More accurate predictions malignancy may help to reduce unnecessary surgery. A machine learning algorithm (MLA) was developed evaluate FNAB via whole slide images (WSIs) predict malignancy. Methods Files were searched all thyroidectomy...
In response to a national mpox (formerly known as monkeypox) outbreak in England, children exposed confirmed case were offered modified vaccinia Ankara-Bavaria Nordic (MVA-BN), third-generation smallpox vaccine, for post-exposure prophylaxis. We aimed assess the safety and reactogenicity humoral cellular immune response, following first reported use of MVA-BN children.