Katy Fidler
A5065719751- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Herpesvirus Infections and Treatments
- Asthma and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Neonatal Respiratory Health Research
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Allergic Rhinitis and Sensitization
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Cystic Fibrosis Research Advances
- Complement system in diseases
- interferon and immune responses
- HIV/AIDS drug development and treatment
- Infectious Diseases and Tuberculosis
- Breastfeeding Practices and Influences
- Kawasaki Disease and Coronary Complications
- Bacterial Infections and Vaccines
Brighton and Sussex Medical School
2015-2025
University of Sussex
2014-2024
Royal Alexandra Children's Hospital
2014-2024
University Hospitals Sussex NHS Foundation Trust
2017-2024
University College London
1995-2023
MRC Clinical Trials Unit at UCL
2023
Medical Research Council
2023
Great Ormond Street Hospital
2004-2023
Royal Sussex County Hospital
2019
University of Brighton
2013
An outbreak of acute hepatitis unknown aetiology in children was reported Scotland1 April 2022 and has now been identified 35 countries2. Several recent studies have suggested an association with human adenovirus this outbreak, a virus not commonly associated hepatitis. Here we report detailed case–control investigation find between adeno-associated 2 (AAV2) infection host genetics disease susceptibility. Using next-generation sequencing, PCR reverse transcription, serology situ...
Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, with outcomes subjected to multivariable analysis.We reanalyzed results in a large cohort use of individual data from 4 involving total 1642 healthy control subjects systematically defined reliable cutoff. Subsequently, were reassessed extend previous associations, adjustment for known outcome...
Serogroup W and Y invasive meningococcal disease increased globally from 2000 onwards. Responding to a rapid increase in serogroup clonal complex 11 (W:cc11) disease, the UK replaced an adolescent booster dose of C conjugate vaccine with quadrivalent MenACWY 2015. By 2018, coverage eligible school cohorts aged 14 19 years was 84%. We assessed impact vaccination programme on carriage.An observational study culture-defined oropharyngeal carriage prevalence before after start students, 15...
To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki disease (KD), bacterial infections, and viral infections.
<title>Abstract</title> Transcriptomic analyses reveal the status of cells, tissues, or organisms, across states health and disease. RNA velocity adds a temporal dimension to single cell analyses, predicting future transcriptomic phenotypic states, based on current spliced unspliced mRNA each cell. We hypothesized that could be adapted predict clinical individuals with acute illness using their whole-blood transcriptome. developed method for quantitative prediction transitions in state from...
We developed an in-house RT-qPCR assay for the detection of SARS-CoV-2 from different sample types. Novel primer and probe sets were designed to amplify 2 regions nucleocapsid (N) gene. Two dual-target multiplex assays then evaluated performance in known samples. An combining one novel pair N (N6), a published region envelope protein (E) extraction control target (MS2), was found have good efficiency low limit detection, be sensitive specific set positive negative clinical Assay maintained...
Mannose-binding lectin (MBL) deficiency has been associated with infections of the respiratory tract and increased disease severity in cystic fibrosis (CF). The mechanism is uncertain, could relate either to systemic or local effects. aim this study was determine, a large cohort children, whether MBL present on airway surface health disease.Bronchoalveolar lavage (BAL) fluid from children without infection (some underlying disease) analysed for neutrophil elastase (NE). Levels were compared...
Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons cystic fibrosis (CF). We assessed prevalence and management in CF centers the United Kingdom found 5.0% 3,805 adults 3.3% 3,317 children had recently been diagnosed NTM. Of those, 44% 47% received treatment.
Abstract Background Currently there is no published data on the inclusion of breastfeeding education within UK medical school curriculum. This study aims to address this knowledge gap and explore students’ perceptions their readiness support breastfeeding. Methods An online survey was used collect from 32 undergraduate schools students. All students in final two years at 30 universities offering a 5- or 6-year medicine course, were eligible. Results Curriculum obtained 26 (81%) institutions....
Mycobacterium chimaera is a slowly growing non-tuberculous mycobacterium associated with outbreaks of fatal infections in patients after cardiac surgery, and it increasingly being detected chronic lung conditions. M can cause disseminated disease, osteomyelitis, skin or soft-tissue infections. We aimed to find new inhibitory compounds drug repurposing opportunities for chimaera, as current therapeutic options often result poor outcomes.
Abstract Background Strategies aimed at antiretroviral therapy (ART)–free remission will target individuals with a limited viral reservoir. We investigated factors associated low reservoir measured as total human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells (PBMCs) perinatal infection (PaHIV). Methods Children from 7 European centers the Early Treated Perinatally HIV Infected Individuals: Improving Children’s Actual Life (EPIICAL) consortium who commenced...
Abstract Background In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine clinical characteristics, performance diagnostic tools, outcome IC tuberculosis (TB) in Europe. Methods Multicenter, matched case-control within Pediatric Tuberculosis Network European Trials Group, capturing TB cases &lt;18 years diagnosed 2000–2020. Results A total 417 were included,...
This updated national UK guideline offers recommendations on the management of genital herpes simplex virus (HSV) in mothers and pregnant people during pregnancy within 4 weeks following birth. It includes for first episode recurrent HSV, HSV preterm pre-labour rupture membranes co-infection with HIV. Recommendations around neonate are made, prevention postnatal transmission, breastfeeding, clinically discordant couples. is aimed at healthcare professionals working sexual health clinics,...
Hereditary angioedema (HAE) is a rare disease characterized by episodes of potentially life-threatening angioedema. For affected children in the United Kingdom, there are relatively few data regarding prevalence, service organization and humanistic burden disease. To improve knowledge these areas, we surveyed major providers care for with HAE. A questionnaire was sent to paediatric centres determine patient numbers, symptoms, diagnostic difficulties, management available services. In...
Live attenuated influenza vaccine (LAIV) is recommended for annual vaccination in children from age 2 years. However, some guidelines recommend against its use with asthma or recurrent wheeze due to concerns over potential induce wheezing.
Abstract Background Optimization of antimicrobial stewardship is key to tackling resistance, which exacerbated by overprescription antibiotics in pediatric emergency departments (EDs). We described patterns empiric antibiotic use European EDs and characterized appropriateness consistency prescribing. Methods Between August 2016 December 2019, febrile children attending 9 countries with suspected infection were recruited into the PERFORM (Personalised Risk Assessment Febrile Illness Optimise...
We report the first case of Helicobacter sp. osteomyelitis in an immunocompetent child. The infection was diagnosed by broad-range 16S PCR followed sequencing resulting amplicon. All other microbiological investigations proved negative. This highlights importance molecular methods diagnosis unsuspected etiological agents and potential role human infection.
To determine the impact of genetic variability in complement activation on early development systemic inflammatory response syndrome (SIRS) general pediatric critical care.Prospective, observational, cohort study.A tertiary intensive care unit United Kingdom.Children with at least one organ failure expected to stay >12 hrs, or an death within 12 hrs.None.A total 299 children were genotyped for functional polymorphisms cascade. We identified factor H as important independent modifier...
Importance Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) vaccines against SARS-CoV-2. Understanding the role autoantibodies these conditions is essential for guiding MIS-C management vaccination strategies children. Objective To investigate presence anticardiac or COVID-19 vaccine-induced myocarditis. Design, Setting, Participants This diagnostic study included with acute vaccine myocarditis, adults...
Children constitute 6-10% of all patients attending the emergency department (ED) by medical services (EMS). However, discordant EMS use in children occurs 37-61% with fever as an important risk factor. We aimed to describe utilisation among febrile European EDs. This study is part observational multicentre assessing management and outcome up 18 years (MOFICHE) twelve EDs eight countries. Discordant was defined absence markers urgency including intermediate/high triage urgency, advanced...