Lucas Baumard
A5045340028- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Gastrointestinal motility and disorders
- Neonatal and Maternal Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Glycosylation and Glycoproteins Research
- Thermal Regulation in Medicine
- Antimicrobial Peptides and Activities
- Neonatal Health and Biochemistry
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Advanced Proteomics Techniques and Applications
- Immune Response and Inflammation
- Bacterial Identification and Susceptibility Testing
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Diabetes Management and Research
- Trauma and Emergency Care Studies
- Hematological disorders and diagnostics
Imperial College London
2023
Alder Hey Children's Hospital
2023
Eaton (United Kingdom)
2023
University of Liverpool
2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2023
Instituto de Salud Carlos III
2023
London School of Hygiene & Tropical Medicine
2023
Queen Mary University of London
2019-2021
King's College London
2017
Immunotherapy using short immunogenic peptides of disease-related autoantigens restores immune tolerance in preclinical disease models. We studied safety and mechanistic effects injecting human leukocyte antigen-DR4(DRB1*0401)-restricted immunodominant proinsulin peptide intradermally every 2 or 4 weeks for 6 months newly diagnosed type 1 diabetes patients. Treatment was well tolerated with no systemic local hypersensitivity. Placebo subjects showed a significant decline stimulated C-peptide...
Long-term cotrimoxazole prophylaxis reduces mortality and morbidity in HIV infection, but the mechanisms underlying these clinical benefits are unclear. Here, we investigate impact of on systemic inflammation, an independent driver mortality. In HIV-positive Ugandan Zimbabwean children receiving antiretroviral therapy, show that plasma inflammatory markers were lower after randomization to continue (n = 144) versus stop 149) cotrimoxazole. This was not explained by illness, progression, or...
Background and aims As the importance of gut–brain interactions increases, understanding how specific gut microbes interact with enteric nervous system (ENS), which is first point neuronal exposure becomes critical. Our aim was to understand dominant human bacterium Bacteroides thetaiotaomicron (Bt) regulates anatomical functional characteristics ENS.Methods Neuronal cell populations, as well enteroendocrine cells, were assessed in proximal colonic sections using fluorescent...
Differentiating between self-resolving viral infections and bacterial in children who are febrile is a common challenge, causing difficulties identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights lead identification of biomarkers with diagnostic potential. This study aimed identify protein for future development into an accurate, rapid point-of-care test that distinguish infections, by recruiting presenting health-care settings...
Abstract Background Studies on procalcitonin (PCT) for identifying sepsis were published as early 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show to be superior CRP in differentiating invasive infections such from viral infections, especially disease course. However, its actual use clinical practice is poorly documented. Our aim was study febrile children attending ED across Europe compare this CRP. Methods The MOFICHE/PERFORM study, a prospective...
Abstract Background Optimization of antimicrobial stewardship is key to tackling resistance, which exacerbated by overprescription antibiotics in pediatric emergency departments (EDs). We described patterns empiric antibiotic use European EDs and characterized appropriateness consistency prescribing. Methods Between August 2016 December 2019, febrile children attending 9 countries with suspected infection were recruited into the PERFORM (Personalised Risk Assessment Febrile Illness Optimise...
Children constitute 6-10% of all patients attending the emergency department (ED) by medical services (EMS). However, discordant EMS use in children occurs 37-61% with fever as an important risk factor. We aimed to describe utilisation among febrile European EDs. This study is part observational multicentre assessing management and outcome up 18 years (MOFICHE) twelve EDs eight countries. Discordant was defined absence markers urgency including intermediate/high triage urgency, advanced...
Receptors located on enteroendocrine cells (EECs) of the colon can detect nutrients in lumen. These receptors regulate appetite through a variety mechanisms, including hormonal and neuronal signals. We assessed effect obesity expression these G-protein coupled (GPCRs) hormones at both mRNA protein level. qPCR immunohistochemistry were used to examine colonic tissue from cohorts patients Netherlands (proximal sigmoid tissue) United Kingdom (tissue across colon) grouped by body mass index...
Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. There is practice variation in management due differences guidelines their usage adherence. We aimed assess whether febrile attending European Emergency Departments (EDs) was according the for fever. This study part MOFICHE study, an observational multicenter including routine data (0-18 years) twelve EDs eight countries. In (excluding bronchiolitis),...
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response infection. The site-specific was characterized plasma derived from well-defined controls patients. found 3862 unique features, we identified 463 distinct intact...
To assess and describe the aetiology management of febrile illness in children with primary or acquired immunodeficiency at high risk serious bacterial infection, as seen emergency departments tertiary hospitals. Prospective data on demographics, presenting features, investigations, microbiology, management, outcome patients within 'Biomarker Validation HR patients' database PERFORM, were analysed. Immunocompromised (< 18 years old) presented to fifteen European hospitals nine countries, one...