A5069624775- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Ischemic Stroke Management
- Cardiovascular Issues in Pregnancy
- Emergency and Acute Care Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Gastroesophageal reflux and treatments
- Health and Medical Studies
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Blood properties and coagulation
Ludwig-Maximilians-Universität München
2015-2025
München Klinik
2008-2025
National and Kapodistrian University of Athens
2023
Imperial College London
2023
LMU Klinikum
2008-2022
Ostschweizer Kinderspital
2005-2021
University of Milan
2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017
Ospedale Maggiore
2017
Hemophilia Center of Iran
2013
The relative importance of previous diagnosis and hereditary prothrombotic risk factors for cerebral venous thrombosis (CVT) in children determining a second or systemic (VT), compared with other clinical, neuroimaging, treatment variables, is unknown.We followed up the survivors 396 consecutively enrolled patients CVT, aged newborn to 18 years (median 5.2 years) median 36 months (maximum 85 months). In accordance international guidelines, 250 (65%) received acute anticoagulation...
Summary. The most problematic complication of haemophilia A treatment is the development inhibitors to FVIII. highest risk developing during first 20 exposure days (EDs). If patient can be brought through this high period without inhibitor development, subsequent low. Therefore, as a pilot project, we developed prophylaxis regimen for 20–50 EDs specifically designed induce tolerance administered FVIII and minimize by avoiding immunological danger signals. Twenty‐six consecutive previously...
The specific type IV phosphodiesterase inhibitor rolipram is a potent suppressor of tumor necrosis factor-alpha (TNF) synthesis. We examined the efficacy for prevention and treatment experimental colitis. To induce colitis, BALB/c mice received 5% dextran sulfate sodium in their drinking water continuously up to 11 days. Colitis was quantified by clinical activity score assessing weight loss, stool consistency, rectal bleeding (range from 0 4); colon length; semiquantitative histologic 6);...
Introduction There has been increasing recognition in recent years that female carriers of haemophilia manifest abnormal bleeding; however, data on the use bleeding assessment tools this population are lacking. Aim Our objective was to validate ISTH ‐ BAT describe symptoms and allow for comparisons with factor levels other patient groups. Methods This a prospective, observational, cross‐sectional study performed by members Global Emerging HE mostasis Panel ( GEHEP ). Unselected consecutive...
Adenosine is a potent anti-inflammatory mediator. Through elevation of endogenous adenosine concentrations the kinase inhibitor GP515 might serve to down-regulate local inflammatory responses. In present study we investigated effect systemic in nonacute model dextran sulfate sodium (DSS)-induced colitis. The clinical score, colon length, histologic cytokine production, and spleen weight from mice with DSS-induced colitis (3.5% DSS drinking water for 11 days) receiving treatment were...
Summary. Severe haemophilia is associated with recurrent joint bleeds, which can lead to haemophilic arthropathy. Subclinical bleeds have also been damage detected using magnetic resonance imaging (MRI). We investigated the development of early changes in clinically asymptomatic joints MRI A or B patients receiving prophylactic therapy. In this single‐centre retrospective cohort study, clinical evidence one ankle and ankle, we performed an scan both ankles session, were enrolled. findings...
Summary Sparse data are available on presentation and management of acute coronary syndromes ( ACS ), including unstable angina non‐ ST ‐ ‐elevation myocardial infarction, among persons with haemophilia PWH ). The aim this study was to determine demographics, bleeding disorder characteristics, cardiovascular risk factors CRF s), interventions, haemostatic protocol, revascularization outcomes complications . Members an international consortium comprising >2000 adult retrospectively...
Background Refugee children and young people have complex healthcare needs. However, issues related to acute provision for refugee across Europe remain unexplored. This study aimed describe the urgent emergency needs of in Europe, identify obstacles providing this care. Methods An online cross-sectional survey was distributed European professionals via research networks between 1 February October 2017 addressing health aged <18 years fulfilling international criteria status, presenting...
The present multicenter cohort study of 107 pediatric PUPs was performed to determine whether the concomitant inheritance factor (F) V G1691A or F II G20210A mutation influences clinical expression severe hemophilia A (HA). Carriers FV and FII mutations had a significantly lower annual bleeding frequency (ABF) than non-carriers (p=0.012). Joint damage (Pettersson score) less in patients with thrombophilia (p=0.022). protective effect thrombophilic risk factors shown for ABF (OR [CIs]:...
Abstract Background Studies on procalcitonin (PCT) for identifying sepsis were published as early 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show to be superior CRP in differentiating invasive infections such from viral infections, especially disease course. However, its actual use clinical practice is poorly documented. Our aim was study febrile children attending ED across Europe compare this CRP. Methods The MOFICHE/PERFORM study, a prospective...