A5018811318- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Microtubule and mitosis dynamics
- Autoimmune Bullous Skin Diseases
- Venous Thromboembolism Diagnosis and Management
- CAR-T cell therapy research
- Health Systems, Economic Evaluations, Quality of Life
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antiplatelet Therapy and Cardiovascular Diseases
- Breast Implant and Reconstruction
- Genomics and Chromatin Dynamics
- Blood properties and coagulation
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Structure and Function
- Biomedical Ethics and Regulation
- Chromosomal and Genetic Variations
- Acute Myocardial Infarction Research
- Breast Cancer Treatment Studies
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Renal Diseases and Glomerulopathies
The Lymphoma Academic Research Organisation
2019-2024
BioMarin (United States)
2024
Cancer Research And Biostatistics
2022
Hôpital Lyon Sud
2019
Erasmus MC Cancer Institute
2019
University of Pennsylvania
2011-2017
Hospital of the University of Pennsylvania
2011-2017
Children's Hospital of Philadelphia
2015
University of California, San Francisco
2005-2013
Hemophilia Center of Western Pennsylvania
2011-2012
OverviewVenous thromboembolism (VTE) is a common and life-threatening condition in patients with cancer. 1,2esults from retrospective study of 66,106 hospitalized adult neutropenic cancer showed that 2.7% to 12.1% these patients, depending on the type malignancy, experienced VTE during their first hospitalization. 1These NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) specifically outline strategies prevent treat either diagnosed or for whom clinically suspected.
JCO
Background: Cell cycle checkpoints maintain the fidelity of somatic cell by ensuring that one step in is not initiated until a previous has been completed. The extent to which play role initial rapid embryonic divisions higher eukaryotes unclear. syncytial Drosophila embryogenesis provide an excellent opportunity address this issue as they are amenable both genetic and cellular analysis. In order study relevance early embryogenesis, we have characterized maternal-effect grapes (grp)...
The renin-angiotensin system regulates blood pressure and sodium balance. angiotensinogen gene which encodes the key substrate within this has been linked to essential hypertension in White Europeans. It suggested that people of West African ancestry may have a different genetic basis for hypertension. In study we tested whether there is linkage Caribbeans from St. Vincent Grenadines. DNA 63 affected sibling pairs with was by analyzing excess allele sharing among siblings genotyped using an...
To evaluate the World Health Organization's (WHO) Bleeding Scale in two studies of eltrombopag adults with chronic immune thrombocytopenia (ITP).Validated scales assessing bleeding ITP are lacking. Data from long-term, phase 3 clinical trials (RAISE: NCT00370331; EXTEND: NCT00351468) that assessed were analyzed to performance WHO Scale.In RAISE, effect size (0.71), standardized response (0.75), and responsiveness statistics (0.57) moderate for bruising assessments. In EXTEND, (0.62) (0.59)...
Introduction There has been increasing recognition in recent years that female carriers of haemophilia manifest abnormal bleeding; however, data on the use bleeding assessment tools this population are lacking. Aim Our objective was to validate ISTH ‐ BAT describe symptoms and allow for comparisons with factor levels other patient groups. Methods This a prospective, observational, cross‐sectional study performed by members Global Emerging HE mostasis Panel ( GEHEP ). Unselected consecutive...
ABSTRACT Cytoplasmic organization, nuclear migration, and division in the early syncytial Drosophila embryo are all modulated by cytoskeleton. In an attempt to identify genes involved cytoskeletal functions, we have examined a collection of maternal-effect lethal mutations induced single P-element transposition for those that cause defects movement, or morphology during embryonic divisions. We describe three mutations, grapes, scrambled, nuclear-fallout, which define previously...
Venous thromboembolic disease is a common and life-threatening condition in cancer patients. Results from recent retrospective study of 66,106 hospitalized adult neutropenic patients showed that 2.74% to 12.10% these patients, depending on the type malignancy, experienced venous thromboembolism (VTE) during first hospitalization. These guidelines specifically outline strategies prevent treat VTE inpatients with either diagnosis or for whom clinically suspected. evaluate therapeutic...
The syncytial divisions of the Drosophila melanogaster embryo lack some well established cell-cycle checkpoints. It has been suggested that without these checkpoints would display a reduced fidelity. To test this idea, we examined division error frequencies in individuals bearing an abnormally long and rearranged second chromosome, designated C(2)EN. Relative to normal chromosome imposes additional structural demands on mitotic apparatus both early embryonic later somatic divisions. We...
ABSTRACT nuclear fallout (nuf) is a maternal effect mutation that specifically disrupts the cortical syncytial divisions during Drosophila embryogenesis. We show nuf gene encodes highly phosphorylated novel protein of 502 amino acids with C-terminal regions predicted to form coiled-coils. During prophase late divisions, Nuf concentrates at centrosomes and generally cytoplasmic throughout rest cycle. In nuf-derived embryos, recruitment actin from caps furrows disrupted. This results in...
ABSTRACT grapes (grp) is a second chromosome (36A-B) maternal-effect lethal mutation in Drosophila melanogaster. We demonstrate that the syncytial nuclear divisions of grp-derived embryos are normal through metaphase cycle 12. However, as progress into telophase 12, microtubule structures rapidly deteriorate and midbodies never form. Immediately following failure midbody formation, sister products collide form large tetraploid nuclei. These observations suggest function embryo to maintain...
Human genetic variation contributes to differences in susceptibility HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) hemophilia patients highly exposed potentially contaminated factor VIII infusions. Individuals with A and documented history of infusions before the introduction viral inactivation procedures (1979–1984) were recruited from 36 treatment centers (HTCs), their variants compared those matched HIV-infected...
Cyclic thrombocytopenia is a rare condition characterized by regular fluctuations in the platelet count, resulting bleeding at time of count nadir. We evaluated male patient whose cycled between <10 × 109/L and maximum >1300 over median every 42 days (range, 28–57 days). Antiplatelet antibodies were present highest titer just prior to nadirs. A pathologic expansion CD3+CD57+ large granular lymphocytes (LGLs) along with clonal rearrangement T-cell receptor (TCR) gamma gene circulating T cells...
Introduction Cerebral microbleeds ( CMB s) represent clinically silent haemorrhagic events. portend negative neurovascular and cognitive outcomes in the general population are associated with impairment persons haemophilia PWH ). Prevalence, patterns, risk factors for s have not been directly compared to without coagulopathy. Aim To examine prevalence, vs normal controls. Methods Adults A or B haemostatically controls were recruited. Subjects excluded if taking an antithrombotic agent other...
Summary In prior microfluidic studies with haemophilic blood perfused over collagen, we found that a severe deficiency (<1% factor level) reduced platelet and fibrin deposition, while moderate (1–5%) only deposition. We investigated: (i) the differential effect of rFVII (0.04–20 n m ) on (ii) contribution contact pathway to a‐induced clotting. Haemophilic or healthy low high corn trypsin inhibitor (CTI, 4 40 μg mL −1 was collagen at an initial venous wall shear rate 100 s . At rate, where...