A5061350746- Aortic aneurysm repair treatments
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Aortic Disease and Treatment Approaches
- Animal Nutrition and Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Peripheral Nerve Disorders
- Advanced biosensing and bioanalysis techniques
- Orthopedic Surgery and Rehabilitation
- Kidney Stones and Urolithiasis Treatments
- Venous Thromboembolism Diagnosis and Management
- CAR-T cell therapy research
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Vascular Procedures and Complications
- Radiopharmaceutical Chemistry and Applications
- Renal and Vascular Pathologies
- Shoulder Injury and Treatment
- Pediatric Urology and Nephrology Studies
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- HIV/AIDS drug development and treatment
- Infectious Aortic and Vascular Conditions
Stanford Health Care
2011-2025
Stanford University
2013-2025
Cardiovascular Institute of the South
2024-2025
Stanford Medicine
2011-2025
Flinders University
2022-2025
Flinders Medical Centre
2022-2025
SA Health
2022-2025
University of California, Los Angeles
2014-2024
Institute for Molecular Medicine
2010-2024
Marist College
2020-2024
OverviewVenous thromboembolism (VTE) is a common and life-threatening condition in patients with cancer. 1,2esults from retrospective study of 66,106 hospitalized adult neutropenic cancer showed that 2.7% to 12.1% these patients, depending on the type malignancy, experienced VTE during their first hospitalization. 1These NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) specifically outline strategies prevent treat either diagnosed or for whom clinically suspected.
Venous thromboembolism (VTE) is common in patients with cancer and increases morbidity mortality. VTE prevention treatment are more complex cancer. The NCCN Guidelines for Cancer-Associated Thromboembolic Disease outline strategies of adult diagnosed or whom clinically suspected. These Insights explain recent changes anticoagulants recommended the cancer-associated VTE.
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Associated Venous Thromboembolic Disease focus on the prevention, diagnosis, and treatment of patients with cancer who have developed or are at risk developing venous thromboembolism (VTE). VTE is a significant concern among patients, heightened risks as well dying from disease. The management often requires multidisciplinary efforts treating institutions. panel comprises specialists various fields: cardiology,...
Abstract Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells 1 . The mitochondria form highly organized networks, which their outer inner membrane structures define bioenergetic capacity 2,3 However, vivo studies delineating relationship between structural organization mitochondrial networks activity have been limited. Here we present an functional analysis phenotypes non-small cell lung (NSCLC) using integrated platform consisting positron emission...
Venous thromboembolism (VTE) is a common, life-threatening condition in patients with cancer, which includes both deep venous thrombosis (DVT) and pulmonary embolism. The occurrence of VTE has been reported to increase the likelihood death for cancer by 2- 8-fold. Pathophysiologic explanations include known hypercoagulability, vessel wall damage, stasis from direct compression, incidence increased additional risks factors. NCCN guidelines specifically outline strategies prevent treat adult...
The NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease outline strategies treatment and prevention of venous thromboembolism (VTE) in adult patients with a diagnosis cancer or whom is clinically suspected. VTE common complication cancer, which places them at greater risk morbidity mortality. Therefore, risk-appropriate prophylaxis an essential component the optimal care inpatients outpatients cancer. Critical to meeting this goal ensuring that get most effective medication...
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic biosynthetic demands proliferation. We tested small-molecule inhibitor glutaminase CB-839 in combination with erlotinib on epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) as a therapeutic strategy simultaneously impair glutamine utilization thereby suppress tumor growth. Here, we show that cooperates drive energetic stress activate AMP-activated...
Background Radiotherapy is increasingly used to treat oligometastatic patients. We sought identify prognostic criteria in patients undergoing definitive hypofractionated image-guided radiotherapy (HIGRT). Methods Exclusively extracranial treated with HIGRT were pooled. Characteristics including age, sex, primary tumor type, interval metastatic diagnosis, number of metastases and organs, site, prior systemic therapy for treatment, metastasis-directed therapy, metastasis associated overall...
// Nicole M.A. White 1,2,* , Olena Masui 3,* Leroi V. DeSouza 3 Olga Krakovska Shereen Metias 1 Alexander D. Romaschin 1,2 R. John Honey 4 Robert Stewart Kenneth Pace Jason Lee Michael AS Jewett 5 Georg A. Bjarnason 6 K.W. Siu and George M. Yousef The Keenan Research Center in the Li Ka Shing Knowledge Institute Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Canada 2 Medicine Pathobiology, University Chemistry Centre for Mass Spectrometry, York University, Surgery,...
ERα gene expression is heritable in humans and prevents obesity mice by improving mitochondrial function via adipocyte Polg1 expression.
Venous thromboembolism (VTE) remains a common and life-threatening complication among patients with cancer. Thromboprophylaxis can be used to prevent the occurrence of VTE in cancer who are considered at high risk for developing this complication. Therefore, it is critical recognize various factors Risk assessment tools available help identify whom discussions regarding potential benefits risks thromboprophylaxis would appropriate. The NCCN Clinical Practice Guidelines Oncology provide...
Contrast-enhanced MRI is typically used to follow treatment response and progression in patients with glioblastoma (GBM). However, differentiating tumor from pseudoprogression remains a clinical dilemma largely unmitigated by current advances imaging techniques. Noninvasive techniques capable of distinguishing these two conditions could play an important role the management GBM other brain malignancies. We hypothesized that PET probes for deoxycytidine kinase (dCK) be differentiate immune...
Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target cancer. PET probes for dCK have been developed are effective mice but suboptimal specificity sensitivity humans. To identify more suitable probe clinical imaging, we compared selectivity of two candidate compounds-[(18)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-β-d-arabinofuranosyl-adenine...
Monitoring genetically altered T cells is an important component of adoptive cell therapy in patients, and the ability to visualize their trafficking/targeting, proliferation/expansion, retention/death using highly sensitive reporter systems that do not induce immunologic response would provide useful information. Therefore, we focused on human gene have potential for translation clinical studies. The objective vivo imaging studies was determine minimum number could be visualized with...
Abstract Purpose: Immunomonitoring of chimeric antigen receptor (CAR) T cells relies primarily on their quantification in the peripheral blood, which inadequately quantifies biodistribution and activation status tissues. Noninvasive molecular imaging CAR by PET is a promising approach with ability to provide spatial, temporal, functional information. Reported strategies rely incorporation reporter transgenes or ex vivo biolabeling, significantly limiting application T-cell imaging. In this...
SUMMARY 1. The aim of the present study was to determine brain sites mediating aspects respiratory and cardiovascular control in adult humans using non‐invasive functional magnetic resonance (/MRI) procedures, thereby avoiding spatial temporal sampling limitations associated with classic neural assessment techniques. 2. We examined activity changes across entire following application loads upon induction blood pressure heart rate alterations. Magnetic signals were visualized a 1.5Tesla...
Probiotics have been demonstrated to promote growth, stimulate immune responses, and improve food safety of poultry. While widely used, their effectiveness is mixed, the mechanisms through which they contribute poultry production are not well understood. Microbial phytases increasingly supplemented in feed digestibility reduce antinutritive effects phytate. The microbial origin these exogenous enzymes suggests a potentially important mechanism probiotic functionality. We investigated phytate...
Nischarin (encoded by NISCH), an α5 integrin–binding protein, has been identified as a regulator of breast cancer cell invasion. We hypothesized that it might be tumor suppressor and were interested in its regulation. examined nischarin expression approximately 300 human normal tissues using quantitative polymerase chain reaction immunohistochemistry. Loss heterozygosity analysis was performed examining three microsatellite markers located near the NISCH locus tissues. generated derivatives...
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers 2 (HK2) and many coexpress HK1 HK2. In contrast to HK1+HK2+ cancers, HK1-HK2+ cancer subsets are sensitive cytostasis induced by HK2shRNA knockdown also synthetic lethality in response combination knockdown, an oxidative phosphorylation (OXPHOS) inhibitor diphenyleneiodonium (DPI), a fatty acid oxidation (FAO) perhexiline (PER). The human multiple myeloma cell lines HK1-HK2+. Here we describe...