A5035034619- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Obesity, Physical Activity, Diet
- Tracheal and airway disorders
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Antimicrobial Resistance in Staphylococcus
- Thermal Regulation in Medicine
- Child and Adolescent Health
- Infective Endocarditis Diagnosis and Management
- Parvovirus B19 Infection Studies
- Breastfeeding Practices and Influences
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Hepatitis C virus research
- Immune Response and Inflammation
- Emergency and Acute Care Studies
- Inflammasome and immune disorders
- Hemodynamic Monitoring and Therapy
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
Children's Clinical University Hospital
2015-2025
Riga Stradiņš University
2015-2024
Imperial College London
2023
National and Kapodistrian University of Athens
2023
West Virginia University
2021
Pauls Stradiņš Clinical University Hospital
2010
Background and objectives: Fever in children is one of the most common reasons for seeking medical attention. Parents often have misconceptions about effects to fever, which leads inappropriate use medication nonurgent visits emergency departments (ED). The aim this study was clarify beliefs on management fever identify healthcare patterns among parents febrile Latvia. Materials Methods: legal guardians attending ED with illness were included study. Participants recruited Children's Clinical...
Background: There is a lack of fast, reliable and non-invasive methods for distinguishing between bacterial viral infections in modern clinical practice. It negatively impacts the effectiveness treatment increases risk unnecessary antibiotic administration thus resistance spread. Using microRNA biomarkers urine may become solution to problems listed. miRNAs are relatively stable can provide an indirect yet specific insight into systemic infections, offering promising diagnostic tool....
Genetic control of immune reactions has a major role in the development rheumatic heart disease (RHD) and differs between patients with fever (RF). Some authors think risk acquiring RHD is associated HLA class II DR DQ loci, but other views exist, due to various HLA-typing methods ways grouping cases. Our goal was determine relations alleles or protection from RF relatively homogeneous clinical manifestations. A total 70 under age 18 years were surveyed Latvia. genotyping DRB1*01 DRB1*18...
ObjectivesTo evaluate the utility of rapid antigen detection testing (RADT) for diagnosis group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics four countries with varied socio-economic and geographic profiles.MethodsWe prospectively evaluated a commercial RADT children aged 2–12 years presenting symptoms to urban Brazil, Croatia, Egypt, Latvia between August 2001 December 2005. We compared performance culture using diagnostic agreement statistics, including sensitivity,...
Abstract Hospital‐acquired hepatitis B (HBV) and C virus (HCV) infections continue to occur despite increased awareness of this problem among the medical community. One hundred six patients were infected in a haematology oncology ward for children, over time period 1996 2000. Serum samples from 45 such 3 personnel used nucleic acid amplification. HBV core, as well HCV core hypervariable region 1 (HVR1) nucleotide sequences, analysed by phylogenetic tree analysis, order characterise...
In accordance with the 1st International pediatric sepsis consensus conference, where was defined as SIRS associated suspected or proven infection, we have identified need to assess prevalence of and in children abnormal temperatures hospitalized The Children's Clinical University Hospital Latvia.A descriptive prospective point study (using two time periods, each 24 h, randomly chosen) conducted on all (n = 943) treated hospital. All - fever hypothermia 92) were included study....
Even though sepsis is one of the common causes children morbidity and mortality, specific inflammatory markers for identifying are less studied in children. The main aim this study was to compare levels high-mobility group box-1 protein (HMGB1), Lipopolysaccharide-binding (LBP), Interleukin-6 (IL-6) C-reactive (CRP) between infected without systemic response syndrome (SIRS) with severe sepsis. second examine HMGB1, LBP, IL6 CRP as bacteraemia. Totally, 140 suspected or proven infections...
The HLA system is being paid more and attention because it very significant in polymorphous immunological reactions. Several studies have suggested that genetic susceptibility to rheumatic fever (RF) heart disease (RHD) linked class II alleles. We hypothesized associations within RHD may be consistent if analysed amongst patients with a relatively homogeneous clinical outcome. A total of 70 RF under the age 18 years were surveyed Latvia. genotyping DQA1, DQB1 DRB1 was performed using PCR...
Abstract Lower respiratory tract infections caused by the human syncytial virus (HRSV) represent an immense burden of disease, especially in young children. This study aimed to investigate evolutionary history HRSV strains isolated Children's Clinical University Hospital (Riga, Latvia) over three consecutive seasons. Of 207 samples from children hospitalized with lower infections, 88 (42.5%) tested positive for RT‐PCR. The seasonal activity started and peaked later than average Northern...
Human bocaviruses (HBoVs) 1–4 belong to the Parvoviridae family, and they infect respiratory or gastrointestinal tracts in children. We investigated prevalence of HBoV1–4 DNAs blood stool samples, IgG IgM plasma children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections five most frequent pathogens. A total 83 paired samples were collected from aged years less. Infection markers HBoV1, 2, 3 (viral DNA and/or antibodies) detected 61 out (73.5%)...
Abstract The aim of this study was to investigate parental perception febrile illness in their children, the most commonly applied management practices, as well expectations from clinicians when coping with fever children. included parents patients admitted Emergency and Observation Department Children’s Clinical University Hospital Rīga, Latvia. Data were collected via semi-structured interviews. All interviews transcribed, transcripts analysed by inductive thematic analysis. Thirty-four...
Serious bacterial infections (SBI) are a significant cause of mortality worldwide. Parental concern and clinician's gut feeling that there is something wrong has been associated with increased likelihood developing SBI in primary care studies. The aim this study to assess the diagnostic value parental at emergency department tertiary hospital. This prospective observational included children fever attending Children's Clinical University hospital Riga between October 2017 July 2018. Data...
Abstract Sepsis is among the leading causes of critical illness worldwide. It includes physiologic, pathologic, and biochemical abnormalities, induced by infection. Novel methods for recognizing a dysregulated inflammatory response predicting associated mortality must be developed. Our aim was to investigate biomarkers that characterize pro-inflammatory anti-inflammatory in patients with fever comparing predictive validity sepsis. 165 were enrolled this study, 55 them had sepsis according...
Children constitute 6-10% of all patients attending the emergency department (ED) by medical services (EMS). However, discordant EMS use in children occurs 37-61% with fever as an important risk factor. We aimed to describe utilisation among febrile European EDs. This study is part observational multicentre assessing management and outcome up 18 years (MOFICHE) twelve EDs eight countries. Discordant was defined absence markers urgency including intermediate/high triage urgency, advanced...
Juvenile idiopathic arthritis (JIA) is a heterogeneous condition and therapeutic strategies vary in different JIA types. The routinely accepted practice to start with Sulphasalazine (SS) as the first line treatment patients HLA B27 positive proves be ineffective large proportion of children.to investigate clinical characteristics, determined allele types their connection antirheumatic homogenous patient groups.56 diagnosed observed over period 2006 2009 included study. HLAB27 were using PCR...
Background: Detection of small proportion serious bacterial infections (SBI) with a potentially life threating course in large group children fever admitted to emergency department (ED) is still complicated. Measurement immature granulocytes (IG) percentage may be used as marker infections. The aim the study was evaluate whether IG useful additional predictive SBI. Methods: This included 258 febrile that were ED. Clinical follow-up, microbiological and radiological tests reference standards...
Myeloperoxidase (MPO) is an enzyme produced by neutrophil leukocytes and released upon activation, killing pathogens causing tissue damage. As neutrophils in neonates are functionally immature, cellular MPO content children may be age-related different from adults. Hematological analyzer ADVIA 2120i (Siemens AG), while routinely assessing count, measures their means of myeloperoxidase index (MPXI). No pediatric reference range for MPXI has been published.We performed a retrospective study...
Abstract Background Human bocavirus 1 is a commonly detected human parvovirus. Many studies have shown as pathogen in association with acute respiratory tract infections children. However, because persists the upper airways for extensive time periods after infection, definition and diagnostics of infection challenging. Until now, detection exclusively, high viral load samples, viremia been associated clinical picture illness. There are no showing messenger ribonucleic acid peripheral blood...
We conducted a cross-sectional study from September 2001 to August 2003 during which children between 2 and 12 years of age presenting with complaint sore throat were recruited urban pediatric clinics in Brazil, Croatia, Egypt Latvia. The objective the was compare clinical signs symptoms countries identify common criteria predicting group A beta hemolytic streptococcal (GAS) pharyngitis. Using single standard protocol all four sites, data recorded swabs obtained for GAS culture 2040...
Aeromonas species are emerging human enteric pathogens. However, there is no systematic analysis of infection in the pediatric population Latvia. The aim study was to describe potential sources, prevalence infection, associated virulence factors and antimicrobial resistance spp. isolated from fecal samples.Stool samples (n = 1360) were obtained Children's Clinical University Hospital between 2020 2021. target patients, 0 18 years age, with a preliminary diagnosis gastroenteritis....
Background and Objectives: Since the first cases of multisystem inflammatory syndrome in children (MIS-C) April 2020, diagnostic challenge has been to recognize this differentiate it from other clinically similar pathologies such as Kawasaki disease (KD) toxic shock (TSS). Our objective is compare clinical signs, laboratory data instrumental investigations between patients with MIS-C, KD TSS. Materials Methods: This retrospective observational study was conducted at Children’s Clinical...