A5029154219- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Bone fractures and treatments
- Childhood Cancer Survivors' Quality of Life
- Healthcare cost, quality, practices
- Transportation Systems and Logistics
- Climate Change and Health Impacts
- DNA Repair Mechanisms
- Viral-associated cancers and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Medical Imaging Techniques and Applications
- T-cell and Retrovirus Studies
- Single-cell and spatial transcriptomics
- Telomeres, Telomerase, and Senescence
- Vitamin D Research Studies
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
Pauls Stradiņš Clinical University Hospital
2022
Riga Stradiņš University
2022
Children's Clinical University Hospital
2012-2021
Latvian Academy of Sciences
1993
Other SectionsAbstractIntroductionMaterials and MethodsResultsDiscussionConclusionsAcknowledgmentsSupplementary InformationFigureTableReference
Monitoring of minimal residual disease (MRD) by flow cytometry (FCM) is a powerful prognostic tool for predicting outcomes in acute lymphoblastic leukemia (ALL). To apply FCM-MRD large, collaborative trials, dedicated laboratory staff must be educated to concordantly high levels expertise and their performance quality should continuously monitored. We sought install unique comprehensive training control (QC) program involving large number reference laboratories within the international...
Myeloperoxidase (MPO) is an enzyme produced by neutrophil leukocytes and released upon activation, killing pathogens causing tissue damage. As neutrophils in neonates are functionally immature, cellular MPO content children may be age-related different from adults. Hematological analyzer ADVIA 2120i (Siemens AG), while routinely assessing count, measures their means of myeloperoxidase index (MPXI). No pediatric reference range for MPXI has been published.We performed a retrospective study...
BACKGROUND The aim of this study was to evaluate impact transplantation bone marrow mesenchymal stromal cells (BM MMSCs) on recovery after polytrauma and fracture repair. METHODS A total 27 Wistar-Kyoto rats were divided into three groups (n = 9): normal control (A), (B), treated with BM MMSC (C). experimental model made male by causing multiple fractures hemorrhagic shock. At 36 hours 9 days surgery, nine received allogeneic MMSCs (1 × 106 per kilogram) intravenously. day before operation...
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Modern treatment protocols allow achievement of long-term event-free survival rates in up to 85% cases, although response varies among different patient groups. It hypothesized that influenced by IL15 gene variations, research results are conflicting. To analyze variations influence response, clinical course and risk developing ALL we performed a case–control family-based study. The study included 81 patients with...
BACKGROUND:Hodgkin lymphoma (HL) transformation into diffuse large B-cell (DLBCL) is uncommon, and scant information has been published on transformed high-grade lymphomas. Therefore, it important to present discuss cases of make new disease progression, diagnosis, treatment more readily available. In this paper, we a case HL DLBCL with atypical dissemination. CASE REPORT:A 39-year-old woman presented severe hip pain. A computed tomography (CT) scan was performed, which showed massive...
Age- and gender-related variability of main lymphocyte subsets (T, B NK cell absolute counts percentages from Ly; T4, T8 DN lymphocytes T cells; T4:T8 T:B ratios) was studied in a large cohort paediatric patients (2 days-17 years) at yearly intervals. A total 4128 six-color TBNK tests performed on BD FACSCanto II flow cytometer were assessed; with immune deficiencies tumours not included. The study revealed significant age- changes all subsets. Absolute T, B, T4 cells dropped neonates to...
Abstract: As in western Europe and the USA, chronic lymphocytic leukaemia (CLL) Latvia is most prevalent type of leukaemia. A total 1509 newly diagnosed cases B‐cell entered study, 440 whom were followed up at Latvian Haematology Centre. The main peculiarities study were: 1) higher incidence disease as compared with other regions former USSR countries, 2) a lower male‐to‐female ratio than countries 3) morbidity among population comparison Russian. positive correlation between stage survival...
Seasonality of 25(OH)D deficiency rate is a factor major clinical and social impact should be considered when planning for appropriate testing tailored correction. We present retrospective cross-sectional analysis over million tests performed in two leading Latvian laboratories – Central Laboratory E.Gulbja Laboratory. Both series demonstrated prominent seasonal variability (<20 ng/ml) critical (<12 ng/ml): the lowest percentage deficient was August, while significant peak found...