A5011966862- Viral gastroenteritis research and epidemiology
- Photoacoustic and Ultrasonic Imaging
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- Nanoplatforms for cancer theranostics
- Pneumonia and Respiratory Infections
- Thermography and Photoacoustic Techniques
- Optical Coherence Tomography Applications
- Respiratory viral infections research
- Analytical Chemistry and Sensors
- Streptococcal Infections and Treatments
- Pediatric Urology and Nephrology Studies
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Photonic and Optical Devices
- Infant Nutrition and Health
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Optical Imaging and Spectroscopy Techniques
- Urinary Tract Infections Management
- Neonatal Health and Biochemistry
- Antibiotics Pharmacokinetics and Efficacy
- Child and Adolescent Health
- SARS-CoV-2 and COVID-19 Research
Ariel University
2019-2025
Schneider Children's Medical Center
2014-2024
Internet Society
2023
Australian Institute of Aboriginal and Torres Strait Islander Studies
2023
Tel Aviv University
2010-2022
University of Minnesota
2010-2021
University of Minnesota System
2008-2018
University of Michigan
2004-2017
Sheba Medical Center
1993-2017
Rabin Medical Center
1996-2017
ABSTRACT Objectives: These guidelines update and extend evidence‐based indications for the management of children with acute gastroenteritis in Europe. Methods: The guideline development group formulated questions, identified data, recommendations. latter were graded Muir Gray system and, parallel, Grading Recommendations, Assessment, Development Evaluations system. Results: Gastroenteritis severity is linked to etiology, rotavirus most severe infectious agent frequently associated...
A targeted gold nanoparticle has been developed as a contrast agent for photoacoustic medical imaging. We have studied cancer cell targeting by antibody conjugated nanorods high By changing the aspect ratio of elongated “rod” shape nanoparticle, its plasmon peak absorption wavelength can be tuned to near IR (700–900nm) an increased penetration depth into biological tissue. Effective and sensitive detection single layer cells are demonstrated. Combining ultrasound with based imaging is...
Young children have a high incidence of influenza and influenza-related complications. This study compared the efficacy safety cold-adapted vaccine, trivalent (CAIV-T) with inactivated vaccine (TIV) in young history recurrent respiratory tract infections (RTIs).Children 6 to 71 months age were randomized receive 2 doses CAIV-T (n = 1101) or TIV 1086), 35 +/- 7 days apart before start 2002-2003 season followed up for culture-confirmed influenza, effectiveness outcomes, reactogenicity, adverse...
Adherence of bacteria via their surface lectins to host epithelial cells is considered an important initial event in bacterial pathogenesis. Mannose-specific (type 1) fimbriae are among the most commonly found enterobacteria. We studied effect aromatic alpha-glycosides mannose on agglutination mannan-containing yeasts by different strains Escherichia coli and adherence guinea pig ileal cells. In both systems these compounds were considerably more effective inhibitors than methyl...
Nanoparticles 100 nm in diameter containing indocyanine green (ICG) have been developed as a contrast agent for photoacoustic (PA) imaging based on (photonic explorers biomedical use by biologically localized embedding PEBBLE) technology using organically modified silicate (ormosil) matrix. ICG is an FDA-approved dye with strong optical absorption the near-infrared (NIR) region, where light can penetrate deepest into biological tissue. A system was used to study image function of PEBBLE...
Shiga-like toxin-producing Escherichia coli have been associated with hemorrhagic colitis and the hemolytic uremic syndrome (HUS). Because Argentina has highest reported frequency of HUS in world, Argentine children were prospectively studied during seasons for evidence toxin-related diseases. On basis serology, fecal cytotoxin neutralization, stool cultures, DNA hybridization colony lysates, most had infection organisms. Children spring-summer diarrhea also commonly (32%, confidence...
OBJECTIVE. The goal was to evaluate the safety, tolerability, and efficacy of an investigational, refrigerator-stable formulation live attenuated influenza vaccine (cold-adapted vaccine-trivalent) against culture-confirmed influenza, acute otitis media, effectiveness outcomes in young children day care over 2 consecutive seasons. METHODS. Children 6 <36 months age who were attending assigned randomly year 1 receive doses or placebo intranasally, 35 ± 7 days apart. In 2, subjects...
Gold nanorods have unusually strong absorption in near infrared, which can be utilized for an optical imaging with nanocolloids. The feasibility of photoacoustic inflammatory responses using bioconjugated gold is demonstrated. To target the stimulated cells, were conjugated to anti-intercellular adhesion molecule-1 (ICAM-1) binds cell surfaces over expressing ICAM-1. A monolayer endothelial cells labeled was scanned a high frequency transducer. Photoacoustic images differentiated inflamed...
Political and public health leaders promoting COVID-19 vaccination should identify the most relevant criteria driving decision. Social media is increasingly used as a source of data powerful communication tool to increase vaccination. In December 2020, we performed cross-sectional social media-based survey addressing personal sentiments toward in USA. Our primary research objective socio-demographic characteristics reasons for 1644 participants’ attitudes regarding We present clear evidence...
Abstract Background Facing the global health crisis of COVID-19, systems are increasingly supporting use telemedicine in ambulatory care settings. It is not clear whether increased will persist after pandemic has resolved. The aims this study were to assess by Israeli pediatricians before and during first lockdown phase pandemic, elucidate how they foresee as a medium medical practice post-pandemic era. Methods A web-based survey was distributed among May 2020, soon end announced. assessed...
Background Vaccines are one of the most important achievements modern medicine. However, their acceptance is only partial, with vaccine hesitancy and refusal representing a major health threat. Influenza vaccines have low compliance since repeated, annual vaccination required. stimulate discussions both in real world online. Social media currently significant source medical information. Elucidating association between social engagement influenza may be applicable to other vaccines, including...
As of October 2021, SARS-CoV-2 infections were reported among 512,613 children and adolescents in Israel (~33% all COVID-19 cases). The 5-11-year age group accounted for about 43% (223,850) affected adolescents. In light the availability Pfizer-BioNTech BNT162b2 vaccine against aged 5-11 years, we aimed to write a position paper pediatricians, policymakers families regarding clinical aspects vaccination COVID-19. first objective this review was describe diverse facets burden children,...
In a retrospective study, 80 episodes of nontyphoid salmonella (NTS) bacteremia in children were compared with 55 adults over 10-year period. The study disclosed major differences the predisposition, clinical presentation, and outcome as well microbiology NTS relation to age. Adults more likely than have predisposing diseases (95% vs. 15%, respectively; P < .0001) receive prior medications 23%, .0001), particularly immunosuppressive agents (58% 5%, .0001). most (67%), infection presented...
The theoretic basis for developing conjugate vaccines, to induce immunoglobulin G (IgG) lipopolysaccharide (LPS) antibodies the prevention of shigellosis, has been described (J. B. Robbins, C.-Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). O-specific polysaccharides (O-SPs) Shigella dysenteriae type 1, S. flexneri 2a, sonnei were covalently bound carrier proteins. Alone, O-SPs not immunogenic in mice. Conjugates these O-SPs, injected into young outbred mice subcutaneously...
Maternal antibodies interfere with hepatitis A vaccination in young infants. We examined the response to a high dose vaccine administered concomitantly combination of diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type b initially seropositive vs. seronegative infants.Three hundred subjects were originally planned be enrolled at age 6 10 weeks and received (formalin-inactivated vaccine, SB-Bio, 720 enzyme-linked immunosorbent assay units)...
Infections of short term, nontunneled, intravascular catheters are often caused by migration organisms from the insertion site. The aim this study was to evaluate effectiveness and safety a chlorhexidine gluconate-impregnated dressing for reduction central venous catheter (CVC) colonization CVC-associated bloodstream infections in infants children after cardiac surgery.This prospective, randomized, controlled conducted pediatric intensive care unit tertiary medical center. Patients 0-18...
Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991–1992, we identified a significantly increased tetracycline (from 23% 87%, P < 0.00001), high trimethoprim–sulfamethoxazole (94%) ampicillin (85%) emerging quinolones (0.5–2%). These data mandate local monitoring its consideration empirical therapy.