A5052574135- Inflammatory Bowel Disease
- Microscopic Colitis
- Pediatric Hepatobiliary Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Celiac Disease Research and Management
- Genetic and Kidney Cyst Diseases
- Child Nutrition and Feeding Issues
- Pancreatitis Pathology and Treatment
- Autoimmune and Inflammatory Disorders Research
- Pregnancy and Medication Impact
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Infant Nutrition and Health
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Digestive system and related health
- Metabolism and Genetic Disorders
- Intestinal Malrotation and Obstruction Disorders
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Pituitary Gland Disorders and Treatments
Ben-Gurion University of the Negev
2016-2025
Soroka Medical Center
2015-2025
Yale University
2023
University Medical Center
2017-2022
University Hospital and Clinics
2022
Jessa Hospital
2016
University of Colorado Denver
1998-2005
Colorado Kidney Care
2001-2002
Children's Hospital Colorado
1998-2002
University of Colorado Health
1999-2001
The accumulation of hydrophobic bile acids plays a role in the induction apoptosis and necrosis hepatocytes during cholestasis. aim this study was to determine freshly isolated rat roles oxidant stress mitochondrial permeability transition (MPT) acid-induced apoptosis. Hepatocytes from adult male Sprague-Dawley rats were incubated for 4 hours buffer containing acid, glycochenodeoxycholic acid (GCDC, 0-500 μmol/L) or hydrophilic glycocholic (GCA), either antioxidants, alpha tocopherol,...
ABSTRACT Background: Benign oesophageal strictures may occur as a complication of caustic ingestion or severe gastro‐oesophageal reflux sequela surgery and other fibrosing conditions. The traditional initial treatment is intraluminal dilation; however, even if frequent, this occasionally not provide adequate lumen capacity give significant symptom‐free intervals, restricturing after dilation difficult challenging. Topical postdilation application an antifibrotic agent, mitomycin‐C, in the...
The epithelial cell adhesion molecule gene (EPCAM, previously known as TACSTD1 or TROP1) encodes a membrane-bound protein that is localized to the basolateral membrane of cells and overexpressed in some tumors. Biallelic mutations EPCAM cause congenital tufting enteropathy (CTE), which rare chronic diarrheal disorder presenting infancy. Monoallelic deletions 3′ end silence downstream gene, MSH2, form Lynch syndrome, cancer predisposition syndrome associated with loss DNA mismatch repair....
Objective To determine the frequency of Niemann-Pick disease type C (NPC) among children being evaluated for neonatal cholestasis during a 2-year period. Methods Medical records were reviewed from all infants with and patients NPC at our center January 1997 through December 1998. Results Forty neonates evaluated, including three diagnosed (age diagnosis, 5–21 months) who originally labeled as having idiopathic (INH). Two adolescents (ages 14 16 years) also this period, one had hepatitis...
Hydrophobic bile acids accumulate in the liver during cholestasis and are believed to cause hepatocellular necrosis apoptosis part through induction of mitochondrial permeability transition (MPT) generation oxidative stress. The purpose this study was determine if human hepatic mitochondria respond manner. MPT measured spectrophotometrically morphologically normal exposed glycochenodeoxycholic acid (GCDC) with without cyclosporin A, an inhibitor MPT, antioxidants, tauroursodeoxycholic...
Abstract Background Alterations in the microbiome have been postulated to drive inflammation IBD. In this pilot randomized controlled trial, we evaluated effectiveness of quadruple antibiotic cocktail addition intravenous-corticosteroids (IVCSs) acute severe colitis (ASC). Methods Hospitalized children with ASC (pediatric ulcerative activity index [PUCAI] ≥65) were into 2 arms: first received antibiotics IVCS (amoxicillin, vancomycin, metronidazole, doxycycline/ciprofloxacin [IVCS+AB]),...
Abstract Background Recent advances in inflammatory bowel disease (IBD) therapies have provided patients with a variety of medications different routes administration. We aimed to assess parental preferences regarding medication administration and identify factors influencing these Methods This cross-sectional study surveyed parents children IBD using comprehensive questionnaire that focused on treatment experiences, preferences, attitudes towards switching from intravenous (IV) subcutaneous...
Rifampin has been proposed to reduce pruritus in children and adults with chronic cholestasis; however, there is a paucity of published data regarding the use rifampin children.In an open trial, 24 were evaluated during 6-year period. Diagnoses included 13 patients extrahepatic biliary atresia (54%), six Alagille's syndrome, three Byler's disease, one each primary sclerosing cholangitis alpha1-antitrypsin deficiency. All had severe that not responded adequately at least 2 months therapy...
Objective Crohn’s disease (CD) pathogenesis associated with dysbiosis and presence of pathobionts in the lumen, intracellular compartments epithelial biofilms. Azithromycin is active all three compartments. Our goal was to evaluate if azithromycin-based therapy can improve response induce remission compared metronidazole alone paediatric CD. Design This blinded randomised controlled trial allocated children 5–18 years 10<Pediatric Disease Activity Index (PCDAI)≤40 azithromycin 7.5 mg/kg,...
Abstract Background The PAILOT trial was a randomized controlled aimed to evaluate proactive vs reactive therapeutic drug monitoring in children with Crohn’s disease (CD) treated adalimumab. Our aim this post hoc analysis of the assess efficacy and safety adalimumab combination treatment comparison monotherapy at week 72 after induction. Methods Participants were 6–17 years old, biologic naïve, moderate severe CD, who responded induction 4. Patients receiving immunomodulators baseline...
To date, research about feeding disorder (FD) has focused almost exclusively on the mother-child dyad, ignoring fathers' roles. The current study investigated father-child interactions with children having FD. sample consisted of 67 (1-3 years old) and their mothers fathers. Thirty-four children, diagnosed a nonorganic-based FD (FD group) 33 without an (control were matched for age, gender, birth order, maternal education. Data collected during home visits. Mothers interviewed father's...
Biliary atresia (BA) is a rare but potentially devastating disease. The European Atresia Registry (EBAR) was set up to improve data collection and develop pan-national interdisciplinary strategy clinical outcomes. From 2001 2005, 100 centers from 22 countries registered with EBAR via its website (www.biliary-atresia.com). In June 2006, the first meeting held evaluate results launch further initiatives. During 5-year period, 60 19 Israel sent completed registration forms for total of 514 BA...
Acute pancreatitis (AP) can be a rare extraintestinal manifestation of inflammatory bowel disease (IBD). There are only few reports AP presenting before the diagnosis IBD. We aimed to characterize demographic, clinical, and laboratory data patients with IBD in whom preceded onset compare presentation between children adults.Pediatric adult as first symptom were retrospectively identified (10 years, 7 university hospitals). Demographic clinical data, type, extension, extracted from charts....