A5001353818- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune cells in cancer
- Multiple Sclerosis Research Studies
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Single-cell and spatial transcriptomics
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Heat shock proteins research
- Psoriasis: Treatment and Pathogenesis
- Advanced Biosensing Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- Gut microbiota and health
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
Broad Institute
2016-2025
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Massachusetts General Hospital
2009-2025
Massachusetts Institute of Technology
2016-2024
Howard Hughes Medical Institute
2023
Center for Neuro-Oncology
2006-2023
Altera (United States)
2022
Colciencias
2022
Universidad de La Laguna
2022
Abstract The gut microbiome plays an important role in immune function and has been implicated several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the subjects with multiple sclerosis (MS, n =60) healthy controls ( =43). Microbiome alterations MS include increases Methanobrevibacter Akkermansia decreases Butyricimonas , correlate variations expression of genes involved dendritic cell maturation, interferon signalling NF-kB pathways circulating T cells monocytes....
The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) participates in the differentiation of FoxP3 + T reg , Tr1 cells, and IL-17–producing cells (Th17). Most our understanding on role AHR compartment results from studies using toxic synthetic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin. Thus, physiological relevance signaling vivo is unclear. We studied mice that carry a GFP reporter endogenous foxp3 locus mutated protein with reduced affinity for its ligands, found...