A5006378082- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Attention Deficit Hyperactivity Disorder
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Neural and Behavioral Psychology Studies
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Neurobiology and Insect Physiology Research
Vanderbilt University
2017-2025
Vanderbilt Health
2020-2025
Vanderbilt University Medical Center
2017-2024
Icahn School of Medicine at Mount Sinai
2014-2023
Allen Institute for Brain Science
2014-2023
Vanderbilt Psychiatric Hospital
2021
Institute of Molecular Biology and Biophysics
2020-2021
Institute of Pharmacology
2018-2020
Addiction Research Foundation
2018
Wake Forest University
2010-2017
Abstract Although both males and females become addicted to cocaine, transition addiction faster experience greater difficulties remaining abstinent. We demonstrate an oestrous cycle-dependent mechanism controlling increased cocaine reward in females. During oestrus, ventral tegmental area (VTA) dopamine neuron activity is enhanced drives post translational modifications at the transporter (DAT) increase ability of inhibit its function, effect mediated by estradiol. Female mice conditioned...
Significance Strong associations between cocaine and the environmental contexts where is administered are thought to drive relapse. The nucleus accumbens (NAc) encodes these cue–reward associations, here we determined how alters ability of cells in NAc respond drug-associated stimuli drug seeking. Using fiber photometry calcium imaging define specific population cells, dopamine D1 receptor-expressing neurons, that information about show can be manipulated attenuate strength prevent Together,...
Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation seek and take the drug. There are currently no clinically available pharmacotherapies treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as potent mediator cocaine-induced adaptations. Here report that G-CSF potentiates increases neural activity nucleus accumbens (NAc) prefrontal cortex. In...
Abstract Addiction to cocaine and other psychostimulants represents a major public health crisis. The development persistence of addictive behaviors comes from complex interaction genes environment - the precise mechanisms which remain elusive. In recent years surge evidence has suggested that gut microbiome can have tremendous impact on behavioral via microbiota-gut-brain axis. this study we characterized influence microbiota cocaine-mediated behaviors. Groups mice were treated with...
More than a normal neurotransmitter The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack et al. found that, with cocaine exposure, there is an intracellular accumulation dopamine in neurons brain region called ventral tegmental area (see Perspective by Girault). Dopamine associates chromatin to initiate previously unknown form epigenetic regulation dopaminylation. This modification has impact on function and, consequently, dopaminergic action...
Abstract Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone comorbid conditions. Here, utilizing the chronic social defeat stress (CSDS) paradigm that induces singular or combined anxiety- depressive-like phenotypes mice, we show ventral tegmental area (VTA) dopamine projecting to basolateral amygdala (BLA) selectively but not depression-like behaviors. Using...
The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing has been implicated several mental disorders. Although one of the largest inputs to LHb originates preoptic area (LPO), little known about how LPO regulation function. Here, we provide evidence exerts bivalent control over through convergent transmission glutamate γ-aminobutyric acid (GABA) onto single neurons. In vivo, both LPO-glutamatergic LPO-GABAergic are activated by aversive...
Tolerance to the neurochemical and psychoactive effects of cocaine after repeated use is a hallmark addiction in humans. However, comprehensive studies on tolerance behavioral, psychoactive, following contingent administration rodents are lacking. We outlined consequences extended access self-administration as it related psychomotor activating, dopamine (DA) elevating, DA transporter (DAT) inhibiting cocaine. Cocaine (1.5 mg/kg/inj; 40 inj; 5 days), which resulted escalation first hour...