A5066023242- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroendocrine Tumor Research Advances
- Receptor Mechanisms and Signaling
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury Research
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- Cerebrovascular and genetic disorders
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Neurological disorders and treatments
- Thyroid Cancer Diagnosis and Treatment
The University of Texas Health Science Center at Houston
2021-2025
Centers for Disease Control and Prevention
2024
National Center for Emerging and Zoonotic Infectious Diseases
2024
The University of Texas Southwestern Medical Center
2014-2023
Southwestern Medical Center
2015-2022
University of Pittsburgh
2022
Harvard University
2011
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia the brain of old C57BL/6 mice (>18 months old) demonstrate that comparison to young mice, one-third are AF, characterized profound changes lipid iron content, phagocytic activity, oxidative stress. Pharmacological depletion eliminated AF following repopulation reversed microglial dysfunction. Age-related...
SummaryA multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved a high predilection for the brain stem and vertebrobasilar arterial system was associated mortality from vessel injury. Effective treatment options remain limited; vitro susceptibility testing organism suggested that it is resistant to all currently approved antifungal medications United States. To...
Women suffer from depression at twice the rate of men, but underlying molecular mechanisms are poorly understood. Here, we identify marked baseline sex differences in expression long noncoding RNAs (lncRNAs), a class regulatory transcripts, human postmortem brain tissue that profoundly lost depression. One such lncRNA, RP11-298D21.1 (which termed FEDORA), is enriched oligodendrocytes and neurons up-regulated prefrontal cortex (PFC) depressed females only. We found virally expressing FEDORA...
Miniaturized neuromodulation systems could improve the safety and reduce invasiveness of bioelectronic neuromodulation. However, as implantable devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters width yet can safely receive wireless using magnetoelectric antennas deliver 14.5-volt stimulation bursts, which enables stimulate activity on-demand through...
Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various severity levels. Primary TBI from blast is commonly characterized by internal injuries, such as vascular damage, neuronal injury, and contusion, without external injuries. Current animal models blast-induced (bTBI) have helped understand the deleterious effects moderate severe forces. However, neurological mild forces remain poorly characterized. Here, we investigated caused combining...
Improvements in acute stroke treatment, including EVT and critical care management, have increased survival rates post-stroke. However, many survivors significant post-stroke disability cognitive impairment. Despite this, the chronic progression long-term sequelae of ischemic pathology remains understudied. Methods: We examined chronicity neurobehavioral recovery progressive neuropathology young male (3 month) middle-aged female (14 C57Bl/6 mice at 3 6 months after a 60-minute transient...
Inflammation is a significant driver of ischemic stroke pathology in the brain. To identify potential regulators inflammation, we performed single-cell RNA sequencing (scRNA-seq) young and aged mouse brains following found that interferon alpha-inducible protein 27 like 2 A (Ifi27l2a) was significantly up-regulated, particularly microglia Ifi27l2a induced by interferons for viral host defense has been linked with pro-inflammatory cellular mechanisms. However, its role neurodegeneration...
Elevated circulating IL-6 levels are associated with poorer outcomes after stroke, and increased serum linked to a higher risk of stroke. binds soluble receptors (sIL-6R) subsequently ubiquitously expressed gp130, initiating proinflammatory trans-signaling. This study tested the hypothesis that inhibiting trans-signaling by administering (s) gp130 improves long-term functional in young mice Recombinant mouse gp130Fc chimera (sgp130) was administered one hour middle cerebral artery occlusion...
Significance This study validates a path toward personalized medicine that utilizes survey of the effective signaling state tumors via posttranslational modification analysis as diagnostic alternative to direct examination genetic mutations. Here, this approach is utilized identify biomarkers for Cdk5-driven tumors. The same could be adapted markers other tumor drivers. As number cancer types in which Cdk5 implicated rising and drugs with potential selectively target are moved clinic,...
Abstract Recent findings from in vivo-imaging and human post-mortem tissue studies schizophrenic psychosis (SzP), have demonstrated functional molecular changes hippocampal subfields that can be associated with hyperexcitability. In this study, we used a subfield-specific GluN1 knockout mouse disease-like perturbation expressed only dentate gyrus (DG) assessed its association physiology psychosis-like behaviors. First, whole-cell patch-clamp recordings to measure the physiological cFos...
Abstract Introduction Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate brain, thereby aggravating injury. Chronically after stroke, repair processes, including angiogenesis, are activated enhance post-stroke recovery. Activated CD13, which facilitates their migration into site However, angiogenic blood vessels play a role in recovery also CD13. Overall, specific contribution CD13 acute chronic outcomes is unknown. Methods...
Abstract Traumatic brain injury ( TBI ) is associated with adverse effects on functions, including sensation, language, emotions and/or cognition. Therapies for improving outcomes following are limited. A better understanding of the pathophysiological mechanisms may suggest novel treatment strategies to facilitate recovery and improve outcome. Aberrant activation cyclin‐dependent kinase 5 (Cdk5) has been implicated in neuronal neurodegeneration. Cdk5 a protein activated via interaction its...
Abstract The striatum controls multiple cognitive aspects including motivation, reward perception, decision-making and motor planning. In particular, the dorsolateral contributes to learning. Here we define an approach for investigating synaptic plasticity in mouse cortico-striatal circuitry interrogate relative contributions of neurotransmitter receptors intracellular signaling components. Consistent with previous studies, show that long-term potentiation (LTP) is facilitated by dopamine,...