A5023144712- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Olfactory and Sensory Function Studies
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Mast cells and histamine
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Metabolomics and Mass Spectrometry Studies
- Probiotics and Fermented Foods
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Diabetes and associated disorders
- Algebraic Geometry and Number Theory
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Commutative Algebra and Its Applications
- Polynomial and algebraic computation
- Cardiac Arrest and Resuscitation
- Neuroscience and Neural Engineering
- Immune Response and Inflammation
- Diet and metabolism studies
- Metabolism and Genetic Disorders
The University of Texas Health Science Center at Houston
2022-2025
The University of Texas MD Anderson Cancer Center
2022
Abstract Recent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different cell subsets been proposed on basis expression levels transcription factors (e.g., T-bet) as well specific surface proteins. CD11b (α-chain integrin) is expressed by several immune types involved in regulation motility, phagocytosis, other essential functions host immunity. Although express CD11b, CD11bhigh subset has not characterized, especially...
Introduction: Neonatal Hypoxic-Ischemic Encephalopathy (nHIE) is a leading cause of infant mortality and long-term morbidity, with males experiencing higher rates poorer neurological outcomes than females. The underlying causes this sex difference remains unclear but may be due to sex-specific inflammatory responses acute brain injury. Hypothesis: We hypothesized that the neutrophil response neonatal injury sexually dimorphic contributes after nHIE. Methods: conducted retrospective study at...
Background: Substantial evidence from recent research suggests an influential and underappreciated force in Alzheimer’s disease (AD) pathogenesis: the pathological signals originate outside brain. Pathogenic bacteria produce amyloid-like proteins “curli” that form biofilms show functional similarities to human amyloid-β (Aβ). These may contribute neurological progression via signaling cascade gut Objective: We propose curli causes neuroendocrine activation brain promotes central Aβ...
Abstract Background : Stroke is a major cause of morbidity and mortality, its incidence increases with age. While acute therapies for stroke are currently limited to intravenous thrombolytics endovascular thrombectomy, recent studies have implicated an important role the gut microbiome in post-stroke neuroinflammation. After stroke, several immuno-regulatory pathways, including aryl hydrocarbon receptor (AHR) pathway, become activated. AHR master regulatory pathway that mediates Among...
Improvements in acute stroke treatment, including endovascular thrombectomy and critical care management, have increased survival rates after stroke. However, many survivors significant neurological deficits, as remains one of the leading causes long-term disability. Despite this, chronic progression sequelae ischemic pathology woefully understudied. This study examined progressive deficits young adult male C57Bl/6 mice at 3 6 months a 60-minute transient middle cerebral artery occlusion...
Neonatal hypoxic ischemic encephalopathy (HIE) increases the risk for attention deficit disorder and autism spectrum disorders in children. Perturbations gut microbiome are associated with behavioral changes pre-clinical models of neurological injury development. However, role behavior after HIE has not been investigated. Also, therapeutic potential microbiota modification remains unexplored. We hypothesize that altering can improve chronic deficits mice. The Rice Vannucci Model (RVM) was...
Introduction: The human skull has traditionally been perceived as a static protective structure guarding the brain and meninges. However, emerging data suggest there is dynamic hematopoietic stem cell niche within upper portion of skull, or calvaria. This important for sensing contributing to central nervous system (CNS) inflammation. Murine models reveal neutrophil migration from that infiltrates ischemic brain, via meninges, following stroke. Methods: To better understand acute dynamics...
Introduction: Neonatal Hypoxic Ischemic Encephalopathy (nHIE) is a leading cause of infant mortality and morbidity worldwide. Males are at greater risk than females, survivors nHIE suffer from major disability with limited therapeutic options. Growing clinical pre-clinical evidence shows neurological injury adversely alters the microbial populations in gut (dysbiosis) depletes anti-inflammatory metabolites exclusively made by microbiota. Replacing key microbially-derived beneficial improves...
Introduction: Neonatal Hypoxic Ischemic Encephalopathy (nHIE) is a major cause of mortality and morbidity in infants, occurring 1.5/1000 live births. Inflammation persists years after injury detrimentally affects neurocognitive outcomes children. Recent evidence shows that neuroinflammation gut alters microbial populations the (gut dysbiosis) reduces level bacteria capable producing beneficial, anti-inflammatory tryptophan (Trp) metabolites. Metabolites are detected by microglia (MG) with...
CD11b expression is essential for immunity due to its role in cell motility and phagocytosis. Leukocytes, including monocytes, neutrophils macrophages, express CD11b. B lymphocytes, which are both adaptive immune cells antigen presenting (APCs), also at varying levels. The of lymphocytes after stroke multifaceted, recent studies have highlighted their deleterious contributions post-stroke recovery cognitive decline. high not been studied the context aging stroke. We hypothesized that...
Microbiome-derived ligands of the aryl hydrocarbon receptor (AHR) including tryptophan-derived indole acetic acid (IAA) have anti-inflammatory effects in some tissues. However, their effect on neuroinflammation after stroke is unknown. Brain-derived AHR (e.g. kynurenine) increase post-ischemia and are detrimental. Consistently, pharmacological inhibition reduces deleterious kynurenine-mediated activation improves outcome. whether IAA-mediated detrimental or beneficial We hypothesized that...
Background: Clinically, ~65% of stroke patients are left with functional impairments after and 15% die shortly their stroke. Increasing evidence suggests that peripheral inflammatory responses play an important role in determining neurological outcome. Mast cells (MCs) one the most rapid responders to injury. MCs release histamine (HA), a pro-inflammatory transmitter enhances inflammation. Gut major source HA. Hypothesis: We hypothesize aged animals will lead robust gut mucosal MC-activation...