A5055259069- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- GDF15 and Related Biomarkers
- Neurological Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Neonatal and fetal brain pathology
- Sphingolipid Metabolism and Signaling
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Neurological Complications and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Lipid Membrane Structure and Behavior
- COVID-19 Clinical Research Studies
- Bone Metabolism and Diseases
- S100 Proteins and Annexins
- Neuropeptides and Animal Physiology
- Educational Leadership and Practices
- Medicinal Plants and Bioactive Compounds
- Intracerebral and Subarachnoid Hemorrhage Research
- Photodynamic Therapy Research Studies
- Leadership, Courage, and Heroism Studies
- Phytochemistry and Bioactivity Studies
- Vascular Malformations Diagnosis and Treatment
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
The University of Texas Health Science Center at Houston
2018-2025
University of Edinburgh
2021-2022
University of Connecticut
2022
UConn Health
2020
Hartford Financial Services (United States)
2014
Hartford Public Library
2014
Abstract Recent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different cell subsets been proposed on basis expression levels transcription factors (e.g., T-bet) as well specific surface proteins. CD11b (α-chain integrin) is expressed by several immune types involved in regulation motility, phagocytosis, other essential functions host immunity. Although express CD11b, CD11bhigh subset has not characterized, especially...
Growth differentiation factor (GDF) 11 levels decline with aging.The age-related loss of GDF has been implicated in the pathogenesis a variety diseases.GDF11 supplementation reversed cardiac hypertrophy, bone loss, and pulmonary dysfunction old mice, suggesting that GDF11 rejuvenating effect.Less is known about potential to improve recovery after an acute injury, such as stroke, aged mice.GDF11/8 were assessed young male mice postmortem human brain samples.Aged subjected transient middle...
In medically refractory idiopathic intracranial hypertension (IIH), venous sinus stenosis (VSS) stenting has been an effective treatment modality. Among patients who experience recurrent symptoms and develop new stenosis, the optimal strategy is unknown. The aim of this study was to investigate role rescue re-stenting in with recurrence after prior successful stenting. This a single center, retrospective review from prospectively maintained IIH registry. Between 2012 2023, underwent...
Abstract Introduction Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate brain, thereby aggravating injury. Chronically after stroke, repair processes, including angiogenesis, are activated enhance post-stroke recovery. Activated CD13, which facilitates their migration into site However, angiogenic blood vessels play a role in recovery also CD13. Overall, specific contribution CD13 acute chronic outcomes is unknown. Methods...
Abstract Background : Stroke is a major cause of morbidity and mortality, its incidence increases with age. While acute therapies for stroke are currently limited to intravenous thrombolytics endovascular thrombectomy, recent studies have implicated an important role the gut microbiome in post-stroke neuroinflammation. After stroke, several immuno-regulatory pathways, including aryl hydrocarbon receptor (AHR) pathway, become activated. AHR master regulatory pathway that mediates Among...
Introduction: Acute stroke leads to the activation of myeloid cells. Activated cells express CD13, which facilitates their migration into site injury. Chronically after stroke, repair processes, including angiogenesis, are activated and enhance post-stroke recovery. However, angiogenic blood vessels play a role in recovery also CD13. Overall, specific contribution CD13 acute chronic outcomes is unknown. Methods: expression was estimated mice humans ischemic stroke. Young (8-12 weeks) male...
Abstract Background Male sex has been identified as a risk factor for worse COVID-19 outcomes. This difference mostly attributed to the complex role of hormones. Cell surface entry SARS-CoV-2 is mediated by transmembrane protease serine 2 (TMPRSS2) which under transcriptional regulation androgens. P450 aromatase enzyme converts androgens estrogens. study measured concentrations enzyme, testosterone, estradiol, and TMPRSS-2 in plasma hospitalized patients elucidate dynamics sex-linked...
Bacteria synthesize numerous types of sphingolipids with various physiological functions. Despite their roles in mediating host inflammation, cellular differentiation, and protection from environmental stress, biosynthetic pathway remains undefined since several essential eukaryotic ceramide synthesis enzymes have no bacterial homologue. Using genetic biochemical approaches, we identified the complete for synthesis. Bioinformatic phylogenetic analyses revealed presence these genes a broad...
Introduction: Neonatal Hypoxic Ischemic Encephalopathy (nHIE) is a leading cause of infant mortality and morbidity worldwide. Males are at greater risk than females, survivors nHIE suffer from major disability with limited therapeutic options. Growing clinical pre-clinical evidence shows neurological injury adversely alters the microbial populations in gut (dysbiosis) depletes anti-inflammatory metabolites exclusively made by microbiota. Replacing key microbially-derived beneficial improves...
Introduction: Ischemic stroke is a major risk factor for cerebral amyloid angiopathy (CAA), which may be driven by alterations in the paravascular transport of cerebrospinal fluid (CSF) amyloid-β 1-40 (Aβ 40 ) through basement membrane (BM). Post-stroke BM thickening favor CSF Aβ deposition within brain microvessels. This study identifies fibronectin (FN) and its receptor, α5β1 integrin, as novel drivers after aged animals. Hypothesis: We hypothesize that stroke-induced FN expression induces...
Introduction: Drugs and mechanical devices for retrieving blood clot are effective; however, they must be used within few hours of stroke onset. No pharmacological therapy has been shown to effective in the recovery phase stroke, which occurs days after initial insult. Growth differentiation factor (GDF) 11, a member transforming growth beta superfamily, ameliorating age associated cardiac hypertrophy, skeletal muscle dysfunction decreased neurogenesis older mice. Therefore, we hypothesized...
Introduction: Growth differentiation factor (GDF) 11 levels decline with aging. This age-related loss of GDF11 has been implicated in a variety diseases. Supplementation reverses cardiac hypertrophy, bone loss, and pulmonary dysfunction old mice, suggesting rejuvenation effect GDF11. Hypothesis: Brain would aged animals, that stroke accelerate the Exogenous administration improve outcomes mice. Methods: GDF11/8 were assessed young mice postmortem human brain samples. In older five days after...
Introduction: Neonatal Hypoxic Ischemic Encephalopathy (nHIE) is a major cause of mortality and morbidity in infants, occurring 1.5/1000 live births. Inflammation persists years after injury detrimentally affects neurocognitive outcomes children. Recent evidence shows that neuroinflammation gut alters microbial populations the (gut dysbiosis) reduces level bacteria capable producing beneficial, anti-inflammatory tryptophan (Trp) metabolites. Metabolites are detected by microglia (MG) with...
CD11b expression is essential for immunity due to its role in cell motility and phagocytosis. Leukocytes, including monocytes, neutrophils macrophages, express CD11b. B lymphocytes, which are both adaptive immune cells antigen presenting (APCs), also at varying levels. The of lymphocytes after stroke multifaceted, recent studies have highlighted their deleterious contributions post-stroke recovery cognitive decline. high not been studied the context aging stroke. We hypothesized that...
The modification of chlorins to fine-tune their optical properties is important for application in medical and technical fields. solution phase, base-induced formation a chromene-annulated chlorin from the corresponding meso-tetrakis(pentafluorophenyl)-2,3-dihydroxychlorin by intramolecular S[Formula: see text]Ar displacement an [Formula: text]-F atom meso-aryl group adjacent hydroxy well-known. Organic transformations performed grinding dry reagents together promise be much greener possibly...