A5060170912- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Spine and Intervertebral Disc Pathology
- Antifungal resistance and susceptibility
- Parkinson's Disease and Spinal Disorders
- Intensive Care Unit Cognitive Disorders
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Gastroesophageal reflux and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Pesticide Exposure and Toxicity
- Pain Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Constructed Wetlands for Wastewater Treatment
- Aging and Gerontology Research
- AI in Service Interactions
Massachusetts General Hospital
2025
Exelixis (United States)
2025
Central Agricultural University
2024
The University of Texas Health Science Center at Houston
2022
Memorial Hermann
2021
Yale University
2016-2020
Doon University
2019
Sarojini Naidu Medical College
2007-2017
University of Miami Health System
2017
University of Vermont
2017
To evaluate the efficacy of rituximab in treatment anti-muscle-specific kinase (MuSK) myasthenia gravis (MG).This was a multicenter, blinded, prospective review, comparing anti-MuSK-positive patients with MG treated to those not rituximab. The primary clinical endpoint Myasthenia Gravis Status and Treatment Intensity (MGSTI), novel outcome that combines Foundation America (MGFA) postintervention status (PIS) number dosages other immunosuppressant therapies used. A priori, an MGSTI level ≤2...
ABSTRACT Introduction : While anticancer immunotherapies have traditionally focused on activation of the immune system, there is recent interest in disinhibition natural antitumor response by targeting checkpoints such as cytotoxic T‐lymphocyte associated antigen‐4 (CTLA‐4) and programmed death‐1 (PD‐1). One humanized monoclonal antibody against PD‐1, pembrolizumab, was recently approved for treatment metastatic malignant melanoma. Methods We report exacerbation myasthenia gravis (MG) after...
Myasthenia gravis (MG), an autoimmune disorder of neuromuscular transmission, is treated by array immunotherapeutics, many which are nonspecific. Even with current therapies, a subset patients has medically refractory MG. The benefits B-cell-targeted therapy rituximab have been observed in MG; however, the duration these after treatment unclear.To evaluate durability response to acetylcholine receptor autoantibody-positive (AChR+) generalized MG.This retrospective case series study included...
Traditionally, routine investigations prior to surgery are considered an important element of preanesthetic evaluation determine the fitness for anesthesia and surgery. During past few decades this practice has been a subject close scrutiny due low yield high aggregate cost. Performing screening tests in patients who otherwise healthy is invariably little value detecting diseases changing anesthetic management or outcome. Thorough history investigation positive answers by clinicians,...
ABSTRACT Introduction : A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)‐antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest may not be efficacious anti–muscle‐specific kinase (MuSK)‐MG. Methods The therapeutic impact of was evaluated data collected for a multicenter, retrospective blinded review rituximab MuSK‐MG. Results Baseline characteristics were similar between ( n = 26)...
Abstract Recent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different cell subsets been proposed on basis expression levels transcription factors (e.g., T-bet) as well specific surface proteins. CD11b (α-chain integrin) is expressed by several immune types involved in regulation motility, phagocytosis, other essential functions host immunity. Although express CD11b, CD11bhigh subset has not characterized, especially...
Background: The Mini-mental State Examination (MMSE) is a globally used instrument for cognitive screening, which nevertheless has bias with respect to education and language. Indo-U.S. Cross National Epidemiology Study developed modified version of MMSE, the Hindi Mental (HMSE), counter this in India among rural illiterate elderly. Thus, two parallel tests are available screening population. This study was conducted explore compare applicability MMSE HMSE when scanning impairment urban...
Aims to compare the efficacy of Proseal laryngeal mask airway(PLMA) and endotracheal tube (ETT) in patients undergoing laparoscopic surgeries under general anaesthesia. This prospective randomised study was conducted on 60 adult patients, 30 each two groups, ASA I-II who were posted for procedures After preoxygenation, anaesthesia induced with propofol, fentanyl vecuronium. PLMA or ETT inserted cuff inflated. Nasogastric (NGT) passed all patients. Anaesthesia maintained N2 O, O2, halothane...
To evaluate the efficacy of a single preoperative dose 600 mg gabapentin for reducing postoperative pain and tramadol consumption after minilap open cholecystectomy.A total 120 adult patients either sex were randomly assigned to receive or matched placebo orally 2 h before operation in double-blind manner. All received using same technique. Postoperative analgesia was provided with intravenous patient-controlled 50-mg initial bolus dose, 20-mg incremental 15-min lockout interval 4-h limit...
Background: Protein kinase, membrane-associated tyrosine/threonine-1 (PKMYT1) phosphorylates cyclin-dependent kinase 1 (CDK1) at threonine-14 (Thr14), inhibiting the catalytic activity of CDK1/cyclin B complex, which blocks cells in G2 from entering M phase. Disruption this PKMYT1-mediated G2/M checkpoint cancer allows mitotic events to occur while DNA synthesis is still ongoing, resulting catastrophic levels damage and cell death. We report preclinical data for XL495, a potent selective...
Luminal organ biopsies are critical for disease diagnosis and obtained using single-bite forceps inserted through the working channel of large endoscopes. Procedures these endoscopes frequently require patient sedation or anesthesia may not be feasible use in pediatric patients. Additionally, forceps-derived can suffer from difficulty maintaining tissue orientation, crush artifacts, lack precise control biopsy depth. The high cost risks have driven development smaller unsedated procedures....
Chronic low back pain is a debilitating condition with complex and multifactorial pathophysiology. Botulinum neurotoxins (BoNTs) have strong analgesic effects, as shown in both animal models of human beings. A randomized, double-blind, placebo-controlled, parallel format study to investigate the efficacy abobotulinum toxin (aboA) chronic was conducted. The cohort consisted 18 patients who received 100 units aboA into each five lumbar extensor spinae muscles unilaterally or bilaterally (total...
Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare chronic disorder characterized by intermittent, non-movement-related involuntary movements. The response to currently available therapies inconsistent and temporary. We describe here patient with infantile-onset PNKD who failed number of pharmaceutical agents used alone or in combination. Treatment oxcarbazepine resulted substantial reduction the frequency severity episodes. has been followed for 4 years now, outcome treatment...