A5015490244- Dialysis and Renal Disease Management
- Thyroid Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Central Venous Catheters and Hemodialysis
- Parathyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Blood Pressure and Hypertension Studies
- Hemoglobinopathies and Related Disorders
- Thyroid and Parathyroid Surgery
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Muscle and Compartmental Disorders
- Renal Transplantation Outcomes and Treatments
- Acute Kidney Injury Research
- Adrenal and Paraganglionic Tumors
- Healthcare cost, quality, practices
- Neurological and metabolic disorders
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- Chronic Disease Management Strategies
University of Michigan
2016-2025
University of Minnesota Medical Center
2025
Arbor Research Collaborative for Health
2015-2024
Royal North Shore Hospital
2015-2024
The University of Sydney
2015-2024
Michigan Medicine
2010-2024
The University of Western Australia
2013-2024
Michigan United
2014-2024
The Kids Research Institute Australia
2024
Northern Sydney Local Health District
2019-2023
Within 24 hours after admission to an intensive care unit (ICU), adults who were expected require treatment in the ICU on 3 or more consecutive days randomly assigned undergo either glucose control, with a target blood range of 81 108 mg per deciliter (4.5 6.0 mmol liter), conventional 180 less (10.0 liter). We defined primary end point as death from any cause within 90 randomization.
Lenvatinib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast 1 through 4, platelet-derived receptor α, RET, KIT, showed clinical activity in a phase 2 study involving patients with differentiated thyroid cancer that was refractory to radioiodine (iodine-131).In our randomized, double-blind, multicenter progressive iodine-131, we randomly assigned 261 receive lenvatinib (at daily dose 24 mg per day 28-day cycles) 131 placebo. At the time disease...
Whether hypoglycemia leads to death in critically ill patients is unclear.We examined the associations between moderate and severe (blood glucose, 41 70 mg per deciliter [2.3 3.9 mmol liter] ≤40 [2.2 liter], respectively) among 6026 intensive care units (ICUs). Patients were randomly assigned or conventional glucose control. We used Cox regression analysis with adjustment for treatment assignment baseline postrandomization covariates.Follow-up data available patients: 2714 (45.0%) had...
RET mutations occur in 70% of medullary thyroid cancers, and fusions rarely other cancers. In patients with RET-altered the efficacy safety selective inhibition are unknown.
Potassium disorders are common in patients with kidney disease, particularly tubular and low glomerular filtration rate. A multidisciplinary group of researchers clinicians met October 2018 to identify evidence address controversies potassium management. The issues discussed encompassed our latest understanding the regulation excretion health disease; relationship intake cardiovascular outcomes, increasing showing beneficial associations plant-based diet data suggest a paradigm shift from...
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout world there significant variability in practice initiating dialysis. Factors such as availability resources, reasons for starting dialysis, timing initiation, patient education and preparedness, modality access, well varied "country-specific" factors significantly affect experiences outcomes. As burden end-stage kidney disease (ESKD) has increased globally, also been a growing recognition...
Background. Levels of physical exercise among haemodialysis patients are low. Increased activity in this population has been associated with improved health-related quality life (HRQoL) and survival. However, results previous studies may not be applicable to the as a whole. The present study provides first description international patterns frequency its association programmes clinical outcomes participants Dialysis Outcomes Practice Patterns Study (DOPPS).
Background Population rates of obesity, hypertension, diabetes, age, and race can be used in simulation models to develop projections ESRD incidence prevalence. Such inform long-range planning for resources needs. Methods We an open compartmental model estimate the prevalence United States through 2030 on basis wide-ranging population obesity death rates. trends race, diabetes were data from Centers Disease Control Prevention’s National Health Nutrition Examination Survey US Census. Results...
Background and objectives Elevated parathyroid hormone levels may be associated with adverse clinical outcomes in patients on dialysis. After the introduction of practice guidelines suggesting higher targets than those previously recommended, changes treatment regimens over time have not been well documented. Design, setting, participants, & measurements Using data from international Dialysis Outcomes Practice Patterns Study, trends secondary hyperparathyroidism therapies past 15 years...
Background A comprehensive analysis of sex-specific differences in the characteristics, treatment, and outcomes individuals with end-stage renal disease undergoing dialysis might reveal treatment inequalities targets to improve patient care. Here we describe hemodialysis prevalence characteristics by sex, compare adult male-to-female mortality rate data from general population, evaluate sex interactions mortality. Methods Findings We assessed Human Mortality Database 206,374 patients...
Abstract Context: Medullary thyroid cancer (MTC) is a rare that can occur sporadically or as part of hereditary syndrome. Objective: To explore the genetic origin MTC, we sequenced protein coding exons approximately 21,000 genes in 17 sporadic MTCs. Patients and Design: We exomes MTCs validated frequency all recurrently mutated other interest an independent cohort 40 comprised both MTC. Results: discovered 305 high-confidence mutations discovery phase, 17.9 somatic per tumor. Mutations RET,...