Michael Walsh
A5013696488- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Diseases and Glomerulopathies
- Otitis Media and Relapsing Polychondritis
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Meta-analysis and systematic reviews
- Blood Pressure and Hypertension Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Central Venous Catheters and Hemodialysis
- Sarcoidosis and Beryllium Toxicity Research
- Atrial Fibrillation Management and Outcomes
- Aortic aneurysm repair treatments
- Statistical Methods in Clinical Trials
- Renal and Vascular Pathologies
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
McMaster University
2016-2025
Population Health Research Institute
2016-2025
Impact
2017-2025
Hamilton Health Sciences
2016-2025
United States Census Bureau
2025
St. Joseph’s Healthcare Hamilton
2015-2024
Department of Health Research
2024
National Kidney Foundation
2023
ChemoCentryx (United States)
2023
Sullivan Nicolaides Pathology
2023
Cyclophosphamide induction regimens for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are effective in 70 to 90% of patients, but they associated with high rates death and adverse events. Treatment rituximab has led remission 80 among patients refractory ANCA-associated may be safer than cyclophosphamide regimens.We compared as therapy vasculitis. We randomly assigned, a 3:1 ratio, 44 newly diagnosed renal involvement standard glucocorticoid regimen plus either at dose 375...
Abstract Background: Intraoperative hypotension may contribute to postoperative acute kidney injury (AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors evaluated the association between intraoperative mean arterial pressure (MAP) risk of AKI injury. Methods: obtained perioperative data for 33,330 noncardiac surgeries at Cleveland Clinic, Ohio. MAP from less than 55 75 mmHg determine threshold where increased. then duration below this their outcomes...
Accurate information regarding prognosis is fundamental to optimal clinical care. The best approach assess patient relies on prediction models that simultaneously consider a number of prognostic factors and provide an estimate patients' absolute risk event. Such should be characterized by adequately discriminating between patients who will have event those not adequate calibration ensuring accurate risk. This Users' Guide help clinicians understand the available metrics for assessing...
Abstract Background: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial due to ischemia that occurs during or within 30 days surgery. The study’s four objectives were determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS. Methods: In this international, prospective cohort study 15,065 patients aged 45 yr older who underwent in-patient surgery, troponin T measured first 3 postoperative days. Patients with a...
The aim of the present study was to detect circulating tumor cells (CTCs) in peripheral blood patients with non-metastatic colon cancer and evaluate whether there is a diurnal variation CTC counts. Furthermore, aimed examine correlation between CTCs TNM stage, other paraclinical variables prognosis.Blood samples were collected from 20 consecutive stage I-III at four different perioperative time points. Detection performed using immunological assay CellSearch®.CTCs detected 1 out 60...
Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality myocardial injury after noncardiac surgery (MINS).To determine association hsTnT potential diagnostic criteria for MINS (ie, due to ischemia associated with mortality).Prospective cohort study of patients aged 45 years or older who underwent inpatient had a postoperative measurement. Starting in October 2008, participants were recruited at 23 centers 13...
DIALYSISandmedicaltherapies,patients with end-stage renal disease (ESRD) have annual mortality rates exceeding 15%. 1 Cardiovascular disease, manifesting frequently as heart failure or sudden death, is responsible for the majority of deaths. This may be due toahighburdenofexposuretotraditional cardiovascular risk factors (before and after initiation dialysis), well ongoing exposure to volume overload, hyperphosphatemia,chronicinflammation,and other uremia-related factors.Taken together,...
More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis.
<h3>Context</h3>Current remission maintenance therapies for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) are limited by partial efficacy and toxicity.<h3>Objective</h3>To compare the effects of mycophenolate mofetil with azathioprine on prevention relapses in patients AAV.<h3>Design, Setting, Participants</h3>Open-label randomized controlled trial, International Mycophenolate Mofetil Protocol to Reduce Outbreaks Vasculitides (IMPROVE), test hypothesis that is more...
<h3>BACKGROUND:</h3> Most randomized controlled trials (RCTs) and meta-analyses of RCTs examine effect modification (also called a subgroup or interaction), in which the an intervention varies by another variable (e.g., age disease severity). Assessing credibility apparent presents challenges; therefore, we developed Instrument for assessing Credibility Effect Modification Analyses (ICEMAN). <h3>METHODS:</h3> To develop ICEMAN, established detailed concept; identified candidate...
<h3>Introduction</h3> The previously reported randomised controlled trial of a consensus regimen pulse cyclophosphamide suggested that it was as effective daily oral (DO) for remission induction antineutrophil cytoplasm autoantibodies-associated systemic vasculitis when both were combined with the same glucocorticoid protocol (CYCLOPS study (Randomised versus Cyclophosphamide therapy ANCA-associated Systemic Vasculitis published de groot K, harper L <i>et al</i> Ann Int Med 2009)). had...
Potassium disorders are common in patients with kidney disease, particularly tubular and low glomerular filtration rate. A multidisciplinary group of researchers clinicians met October 2018 to identify evidence address controversies potassium management. The issues discussed encompassed our latest understanding the regulation excretion health disease; relationship intake cardiovascular outcomes, increasing showing beneficial associations plant-based diet data suggest a paradigm shift from...
To determine the association between characteristics at diagnosis and time to first relapse in a large cohort of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).We studied long-term followup data from 4 clinical trials that included newly diagnosed broad spectrum AAV severity manifestations. Patient disease baseline were used competing risk regression models as event interest death event.We assessed 535 1,804 patient-years relapse. At diagnosis, median age was...
Background Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. While many assume bias is the cause overestimation, theoretical considerations suggest that random error may be an equal or more frequent cause. The independent impact on meta-analyzed effects has not previously been explored. It suggested surpassing optimal information size (i.e., required meta-analysis sample size) provides sufficient protection against...
Assessment of heterogeneity is essential in systematic reviews and meta-analyses clinical trials. The most commonly used measure, I(2), provides an estimate the proportion variability a meta-analysis that explained by differences between included trials rather than sampling error. Recent studies have raised concerns about reliability I(2) estimates, due to their dependence on precision time-dependent biases. Authors also advocated use 95% confidence intervals (CIs) express uncertainty...
Objectives The RITUXVAS trial reported similar remission induction rates and safety between rituximab cyclophosphamide based regimens for antineutrophil cytoplasm antibody (ANCA)-associated vasculitis at 12 months; however, immunosuppression maintenance requirements longer-term outcomes after in ANCA-associated renal are unknown. Methods Forty-four patients with newly diagnosed involvement were randomised, 3:1, to glucocorticoids plus either (375 mg/m 2 /week×4) two intravenous pulses (n=33,...
Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated high rates of morbidity mortality due uncontrolled disease treatment toxicity. Small randomized trials suggest adjunctive plasma exchange may improve control, while observational evidence suggests that current oral glucocorticoid doses severe infections in patients AAV. A study both...
Cyclophosphamide induction regimens are effective for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but associated with infections, malignancies and infertility. Mycophenolate mofetil (MMF) has shown high remission rates in small studies of AAV.We conducted a randomised controlled trial to investigate whether MMF was non-inferior cyclophosphamide AAV. 140 newly diagnosed patients were randomly assigned or pulsed cyclophosphamide. All received the same oral...
Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether strategy of starting treatment doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over oral corticosteroids.We did pragmatic, multicentre, parallel-group randomised controlled trial adults bullous (three or more blisters at two sites and linear basement membrane IgG C3). Participants were randomly assigned to (200 mg per day) prednisolone (0·5 mg/kg...
In the 330-patient ADVOCATE trial of avacopan for treatment antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 group and 4.1 prednisone (P = 0.029) at week 52. This new analysis examines results patient subgroup with severe insufficiency enrollment into trial, i.e., eGFR ≤20 m2.eGFR was determined baseline over course trial. Changes were...