Matthias H. Busch
A5034259007- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Long-Term Effects of COVID-19
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Complement system in diseases
- Systemic Sclerosis and Related Diseases
- Ion channel regulation and function
- Sarcoidosis and Beryllium Toxicity Research
- Peripheral Neuropathies and Disorders
- Cardiac electrophysiology and arrhythmias
- Immunodeficiency and Autoimmune Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Cardiomyopathy and Myosin Studies
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
- Reproductive tract infections research
- Linguistics, Language Diversity, and Identity
Maastricht University
2012-2024
Geneeskundige en Gezondheidsdienst
2024
Friedrich Schiller University Jena
2024
Maastricht University Medical Centre
2020-2023
ChemoCentryx (United States)
2023
Cardiovascular Institute Hospital
2022
Laurentius Ziekenhuis
2022
Saxon State Ministry for Science and the Arts
2019
Heidelberg University
2016
University Medical Center
2016
In the 330-patient ADVOCATE trial of avacopan for treatment antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 group and 4.1 prednisone (P = 0.029) at week 52. This new analysis examines results patient subgroup with severe insufficiency enrollment into trial, i.e., eGFR ≤20 m2.eGFR was determined baseline over course trial. Changes were...
• Prevalence of ESBL/pAmpC-producing E. coli is highest in chicken meat. Characteristics isolates from turkey meat are significantly different to those chicken. CTX-M group among the ESBL/pAmpC producing was (26.0%) and (24.0 %). Minced beef or pork contaminated at higher frequency than pork. Vegetables only a very low level Germany. The spread extended-spectrum β-lactamases (ESBLs) Escherichia major public health issue ESBL-producing bacteria frequently reported livestock. For assessment...
Recently, we reported the phase II portion of adaptive II/III PANAMO trial exploring potential benefit and safety selectively blocking C5a with monoclonal antibody vilobelimab (IFX-1) in patients severe coronavirus disease 2019 (COVID-19). The potent anaphylatoxin attracts neutrophils monocytes to infection site, causes tissue damage by oxidative radical formation enzyme releases, leads activation coagulation system. Results demonstrated that inhibition was safe secondary outcomes appeared...
Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for AEs following SARS-CoV-2 vaccination in patients with various immune-mediated inflammatory diseases (IMIDs).
Objectives To compare the cumulative incidence and disease severity of reported SARS-CoV-2 omicron breakthrough infections between patients with immune-mediated inflammatory diseases (IMID) on immunosuppressants controls, to investigate determinants for infections. Methods Data were used from an ongoing national prospective multicentre cohort study vaccination responses in IMID Netherlands (Target-to-B! (T2B!) study). Patients wih controls (patients not healthy controls) who completed...
SARS-CoV-2-specific CD8
Abstract During the COVID‐19 pandemic, daily life of many patients with dermatological immune‐mediated inflammatory diseases (DIMIDs), such as atopic dermatitis (AD), psoriasis, and vitiligo, was impacted by social restrictions caused (fear of) morbidity, mortality associated COVID‐19, vaccine hesitancy. This prospective observational, multicenter, multidisciplinary cohort study explored impact disease vaccination on DIMIDs, specifically AD, vitiligo. Data from DIMIDs were collected part...
Abstract The risk of a venous thrombotic event (VTE) is increased in patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV); however, detailed understanding the underlying mechanisms hypercoagulability limited. We assessed prospectively different coagulation parameters 71 active AAV at baseline and after 6 months follow-up. D-dimers fibrinogen were most presentation remained elevated half patients. Particularly, thrombin-antithrombin (T:AT) complex activated...
ANCA-associated GN is a common cause of rapidly progressive GN, with high relapse rates. The early recognition an importance to prevent loss kidney function. Urinary soluble CD163 has been identified as promising marker active GN. Previous studies, however, are limited by the lack histologic data.We analyzed urinary in 95 patients vasculitis who underwent biopsy. In total, 125 tissue sections (first biopsy, n=67; repeated n=58) concurrent 24-hour urine samples were studied. Correlation...
Neutrophil extracellular traps (NET) have been implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Here, we developed a novel, label-free, high-throughput bio-impedance technique to effectively measure serum NET-inducing activity. Using this technique, activity derived from patients with AAV was assessed prospective cohort 62 presenting active major organ involvement. Thirty-five presented new and 27 relapsing AAV, whom 38 had kidney...
Abstract Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with L-type calcium channel. Knockdown Myoscape cardiomyocytes decreases transients associated smaller Ca 2+ amplitudes and lower diastolic content. Likewise, channel currents are significantly diminished on ablation, downregulation reduces contractility cardiomyocytes. Conversely, overexpression increases global...
Objective. To evaluate in patients with AS (i) the fluctuation self-reported disease activity (BASDAI), patient global well-being [visual analogue scale (VAS)–global] and spinal pain (VAS-pain) during 2 years of follow-up on a group level (ii) clinical relevance these fluctuations level. Methods. Dutch from Outcome International Study cohort completed patient-reported outcome measures every months over years. On level, mixed linear models were used to analyse whether constant time. relevant...
Abstract Background Patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressants (ISPs) may have impaired long-term humoral immune responses and increased disease activity after SARS-CoV-2 infection. We aimed to investigate against a primary infection in unvaccinated IMID patients ISPs. Methods active treatment ISPs controls (i.e. not ISP healthy controls) confirmed before first vaccination were included from an ongoing prospective cohort study (T2B! study). Clinical...
The aim of this study was to investigate further the role chlamydiae as pathogens in genital tracts sows at slaughter. Genital 101 randomly selected were collected and specimens tract localizations systematically examined for using immunohistochemistry PCR. In 10 sows, Chlamydia psittaci DNA detected by PCR, typed 'serotype 1' nine cases avian strain 6 BC one animal. However, all negative chlamydiae. Pooled samples scalding tank water additionally investigated 95 animals. Of these samples,...
Leukocyte chemotaxis is deemed instrumental in initiation and progression of atherosclerosis. It mediated by G-protein-coupled receptors (e.g., CCR2 CCR5), the activity which controlled receptor kinases (GRKs). In this study, we analyzed effect hematopoietic deficiency a potent regulator kinase (GRK2) on atherogenesis. LDL receptor-deficient (LDLr–/–) mice with heterozygous GRK2 deficiency, generated bone marrow transplantation (n=15), displayed dramatic attenuation plaque development, 79%...
Ever since the global administration of various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in response to disease 2019 (COVID-19), temporal associations between glomerulopathies and vaccination have been reported.1Li N.L. Coates P.T. Rovin B.H. COVID-19 followed by activation glomerular diseases: does association equal causation?.Kidney Int. 2021; 100: 959-965https://doi.org/10.1016/j.kint.2021.09.002Abstract Full Text PDF PubMed Scopus (20) Google Scholar Minimal...
Vilobelimab, a complement 5a (C5a)-specific monoclonal antibody, reduced mortality in critically ill COVID-19 patients phase 3 multicentre, randomized, double-blind, placebo-controlled study. As part of the study, vilobelimab concentrations and C5a levels as well antidrug antibodies (ADAs) to were analysed.From Oct 1, 2020 4, 2021, 368 invasively mechanically ventilated randomized: 177 randomly assigned receive while 191 received placebo. Pharmacokinetic sampling was only performed at sites...
Rituximab (RTX) and cyclophosphamide (CYC) are effective remission-induction therapies in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, combining these may favor prognosis patients with a major disease presentation. We conducted retrospective study to compare treated combination of RTX low dose CYC (RTX-CYC) or only, both followed by tailored maintenance RTX, regard long-term outcomes.Patients the Maastricht University Medical Center between March 2007...