A5065920401- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Xenotransplantation and immune response
- Oral and gingival health research
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Electrolyte and hormonal disorders
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Palliative Care and End-of-Life Issues
- Vasculitis and related conditions
- Ion Transport and Channel Regulation
- Organ and Tissue Transplantation Research
- Drug-Induced Hepatotoxicity and Protection
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Complement system in diseases
- Pregnancy and Medication Impact
- Diabetes Treatment and Management
- Genetic and Kidney Cyst Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Virus-based gene therapy research
- Family and Patient Care in Intensive Care Units
- Drug Transport and Resistance Mechanisms
Odense University Hospital
2012-2025
University of Southern Denmark
1995-2025
ChemoCentryx (United States)
2023
Danish Society of Nephrology
2014
Arkana Laboratories
1986-2002
Herlev Hospital
1991
Statens Serum Institut
1986
In the 330-patient ADVOCATE trial of avacopan for treatment antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 group and 4.1 prednisone (P = 0.029) at week 52. This new analysis examines results patient subgroup with severe insufficiency enrollment into trial, i.e., eGFR ≤20 m2.eGFR was determined baseline over course trial. Changes were...
Abstract Background Patients with chronic kidney disease and their families request early continuous advance care planning. Based on user involvement, an planning intervention was developed to support patients, family members healthcare professionals (HCPs) in conversations a nephrology outpatient setting. Objective To explore the experiences perceptions of among patients disease, professionals. Design An exploratory qualitative study phenomenological‐hermeneutic approach. Participants Six...
Abstract. The contention that cyclosporin A (CyA) nephrotoxicity may be due to renal afferent arteriolar constriction was inferred from rat studies showing CyA increase vascular resistance, reduce glomerular filtration rate (GFR) and delivery of tubular fluid the end proximal tubule loop Henle (Vprox), fractional reabsorption. In order test whether mechanism human is similar its analogue, treatment causes prolonged malfunction after drug withdrawal, function investigated with clearance...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) carries a high risk of morbidity and mortality, with outcomes modified by treatment an incidence that may be increasing. We examined temporal changes in mortality during 2000-15 using nationwide healthcare registries.Patients incident AAV were identified International Classification Diseases Version 10 (ICD10) codes grouped according to inclusion year (Period 1: 2000-04, Period 2: 2005-09, 3: 2010-15). Log link...
Renal function was studied in rats treated with cyclosporin A (CyA). Peroral CyA 25 mg kg-1 day-1 depressed glomerular filtration rate (GFR) from 1284 +/- 429 to 500 228 microliters min-1 g-1 kidney weight (KW) (P less than 0.01). Absolute of proximal tubular reabsorption (APR) decreased 1075 437 468 203 min g KW-1 Proximal fractional (PFR) 67.7 and 68.5% measured the TT/OT lithium-clearance methods, respectively. Amiloride had no effect on rats. Acute isotonic volume expansion increased GFR...
Abstract. Experimental evidence indicates that cyclosporin A (CyA) nephrotoxicity is due to renal arteriolar constriction, reducing blood flow, glomerular filtration rate (GFR), and delivery of tubular fluid from the end proximal tubule loop Henle. The fractional reabsorption (PFR) increased. Therefore, impact on function vasodilating agents was studied in rats given CyA. Conscious catheterized clearance techniques were used. In acute experiments a preexisting CyA‐nephrotoxicity resistant...
A limited number of studies have assessed health-related quality life (HRQoL) in autosomal dominant polycystic kidney disease (ADPKD). Results to date been conflicting and generally focused on patients with later stages the disease. This study aimed assess HRQoL ADPKD across all disease, from early chronic (CKD) end-stage renal involving cross-sectional patient-reported outcomes retrospective clinical data was undertaken April–December 2014 Denmark, Finland, Norway Sweden. Patients were...
There is limited real-world data on the economic burden of patients with autosomal dominant polycystic kidney disease (ADPKD). The objective this study was to estimate annual direct and indirect costs ADPKD by severity disease: chronic (CKD) stages 1–3; CKD 4–5; transplant recipients; maintenance dialysis patients. A retrospective undertaken April–December 2014 in Denmark, Finland, Norway Sweden. Data medical resource utilisation were extracted from charts asked complete a self-administered...
Recent studies in liver and kidney transplant recipients revealed a nephrotoxic adverse effect of the new macrolide immunosuppressant FK-506. Therefore FK-506 0.1 to 0.8 mg per kg day was investigated rats using clearance methods including lithium clearance. In given or placebo during 1 week nephrotoxicity characterized by slight reduction inulin The end proximal delivery as measured decreased treated for 4 weeks with mg/kg/day glomerular filtration rate (GFR) had 23% GFR found controls...
The oral formulation of cyclosporin A (CsA)-Sandimmun-has a highly variable absorption. development CsA microemulsion-Sandimmun Neoral-resulted in increased bioavailability, and decreased variability first (Sandimmun) interacted with numerous other drugs grapefruit juice. Several these interactions might be explained by pre-systemic metabolism cytochrome-enzyme (e.g. CYP3A4) located the enteral mucosa, and/or via P-glycoprotein-mediated transport back from enterocytes into gut lumen. purpose...
Background. Hyperglycemia has been shown to influence primary function of islet isografts. In this study, we investigated the hyperglycemia on allogeneic islets transplanted into spontaneously diabetic recipients (NOD) or streptozotocin-induced mice (BALB/c). Methods. Mice with moderate, severe, very severe underwent transplantation a marginal number (350 BALB/c and 700 NOD mice). To prevent alloimmune response, used blockade CD28:B7 CD40L:CD40 costimulatory signaling pathways determine...
This long-term study elucidates the development and reversibility of functional morphological cyclosporin (CsA) nephropathy. Sprague–Dawley rats were given CsA (12.5 or 25 mg/kg per day) for 4, 8 16 weeks, during first half 8- 16-week period, vehicle second half. Controls throughout study. Renal function was investigated with clearance methods (inulin, lithium, sodium potassium). CsA-treated developed a focal renal interstitial fibrosis, severity which correlated to accumulated dose...
Physiological bicarbonate/lactate-based solutions may correct acidosis in a better way than standard lactate-based solutions. In this study, new 25 mmol/L bicarbonate/10 lactate peritoneal dialysis (PD) solution was compared with 35 mmolL solution.This prospective open label study. All patients had 2-week baseline period using the solution, followed by 8 weeks on bicarbonate/ and 2 solution.Four Danish four Spanish nephrology centers.40 well-dialyzed (creatinine clearance > 55 L/week/1.73 m2...
Background. The erythropoiesis-stimulating protein darbepoetin alfa (Aranesp®) can be given intravenously (IV) or subcutaneously (SC). Despite a SC bioavailability of only 37%, IV dose requirements were comparable in previous studies designed to evaluate other aspects anaemia treatment. present study was compare vs requirements. Methods. A single-centre open-label, prospective and randomized crossover undertaken 71 stable haemodialysis patients. After run-in period 20 week treatment with...
Patients with chronic kidney disease and their families strongly request advance care planning. They want it to start early-before treatment decisions are made-and be an ongoing process during illness trajectory. Previous international studies show that health professionals find there significant barriers impact the extent of involvement in planning.To identify Danish nephrology professionals' knowledge attitudes planning status current practice Denmark.An anonymous, cross-sectional survey...
ABSTRACT Background This study validates the application of Systematized Nomenclature Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark encoded form, aiming support robust epidemiological research on causes, treatments and prognosis diseases. Methods Kidney biopsy reports from 1 January 1998 31 December 2018 were randomly extracted Danish National Patobank, using SNOMED codes. A 5% sample was selected, nephrologists assessed corresponding records,...