A5061620649- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Muscle metabolism and nutrition
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Otitis Media and Relapsing Polychondritis
- Bone health and osteoporosis research
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Function and Risk Factors
- Central Venous Catheters and Hemodialysis
- Growth Hormone and Insulin-like Growth Factors
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
- Cell Adhesion Molecules Research
Aarhus University Hospital
2016-2025
Aarhus University
2006-2025
ChemoCentryx (United States)
2023
AIDS Clinical Trials Group
2015
Vejle Sygehus
2006
Mayo Clinic
2005
Regional Hospital Holstebro
1999
In the 330-patient ADVOCATE trial of avacopan for treatment antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 group and 4.1 prednisone (P = 0.029) at week 52. This new analysis examines results patient subgroup with severe insufficiency enrollment into trial, i.e., eGFR ≤20 m2.eGFR was determined baseline over course trial. Changes were...
Background. Peritoneal dialysis (PD) has become a well-established complementary alternative to haemodialysis (HD) as first-line renal replacement modality. At our department, ∼50% of the end-stage disease patients are started urgently on chronic due late referral or unexpected deterioration residual function. These patients—although suitable for PD—were previously HD via temporary central venous catheter. Since January 2000, have been offered urgent start PD right after PD-catheter...
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The Plasma Exchange (PLEX) and Glucocorticoids (GC) in Severe AAV (PEXIVAS;NCT00987389) trial was the largest first to enroll participants with DAH requiring mechanical ventilation. Objectives: Evaluate characteristics, treatment effects, outcomes for patients without DAH. Methods: PEXIVAS randomized 704 PLEX or no-PLEX reduced...
Abstract Background Patient-reported Outcome (PRO) measures may be used as the basis for out-patient follow-up instead of fixed appointments. The patients attend from home by filling in questionnaires developed that specific aim and patient group (telePRO). are handled real time a algorithm, which assigns an outcome color reflecting clinical need. algorithms (named solutions) constructed consensus process with clinicians. We aimed to describe AmbuFlex’ telePRO solutions algorithm outcomes...
A new, fast and reliable radioimmunoassay for measurement of brain natriuretic peptide (BNP) in human plasma has been developed its application is reported healthy subjects patients with congestive heart failure, chronic renal liver cirrhosis essential hypertension. The antibody was raised rabbits, the tracer made by iodogen method polyethylene glycol used separation free bound tracer. BNP extracted from using Sep-Pak C18 cartridges. recovery unlabelled added to 77.5±6.2% (mean±SD)....
♦ Objective To describe basic demographics and clinical outcomes among elderly end-stage renal disease (ESRD) patients physically dependent on a caregiver maintained an assisted automated peritoneal dialysis (AAPD) program. Design Retrospective single-center study based patient records data files. Setting University Hospital. Patients 64 AAPD followed for 1.012 treatment months. Assistance care was delivered by 52 briefly trained teams of visiting nurses or nursing home staff. Result Crude...
Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce proteinuria slow the progression disease and associated risk cardiovascular Here, we propose mechanistic coupling between proprotein convertase subtilisin/kexin type 9 (PCSK9), regulator cholesterol therapeutic target in PCSK9 undergoes glomerular filtration captured by megalin, receptor responsible for driving protein reabsorption proximal tubule. Accordingly, megalin-deficient mice patients carrying...
Fracture risk is increased in chronic kidney disease (CKD), but assessment of bone fragility remains controversial these patients. This study investigated the associations between turnover markers, mineral density (BMD), and prevalent fracture a cohort transplantation candidates.Volumetric BMD spine hip was measured by quantitative computed tomography. Parathyroid hormone (PTH), bone-specific alkaline phosphatase, procollagen type-1 N-terminal propeptide, tartrate resistant C- telopeptides...
In Denmark, outpatient follow-up for patients with chronic kidney disease (CKD) is changing from in-hospital visits toward more remote health care delivery. The nonuse of patient-reported outcomes (PROs) a well-known challenge, and it can be difficult to explain which mechanisms interventions influence the outcome. Process evaluation may, therefore, used answer important questions on how why work, aiming enhance implications clinical practice.
Animal studies have indicated that increased nitric oxide (NO) synthesis plays a significant role in the renal adaptation to sodium intake. To investigate of NO during intake humans, we studied effect acute, systemic injection N G -monomethyl-l-arginine (l-NMMA) on hemodynamics [glomerular filtration rate and plasma flow (GFR RPF, respectively)], urinary excretion (FE Na ), [mean arterial blood pressure heart (MAP HR)], levels several vasoactive hormones 12 healthy subjects high (250...
During fasting, a lack of GH increases protein loss by close to 50%, but the underlying mechanisms remain uncertain. The present study tests hypothesis that anabolic actions depend on mobilization lipids. Seven normal subjects were examined four occasions during 37-h fast with infusion somatostatin, insulin, and glucagon for final 15 h: 1) replacement, 2) replacement antilipolysis acipimox, 3) without antilipolysis, 4) intralipid. Urinary urea excretion, serum concentrations, muscle...
Thyroid hormones have significant metabolic effects, and muscle wasting weakness are prominent clinical features of chronic hyperthyroidism. To assess the underlying mechanisms, we examined seven hyperthyroid women with Graves' disease before (Ht) after (Eut) medical treatment control subjects (Ctr). All underwent a 3-h study in postabsorptive state. After regional catheterization, protein dynamics whole body forearm muscles were measured by amino acid tracer dilution technique using [ 15...
A marked reduction in serum levels of bioactive insulin-like growth factor-I (IGF-I) has been observed fasting hemodialysis (HD) patients during a 4-h HD session. The aim the present study was to investigate beneficial effect hyperinsulinemia on IGF-I and inflammatory biomarkers. In randomized cross-over study, 11 non-diabetic received standardised session with either: 1) no treatment, 2) glucose infusion (10% glucose, 2.5 mL/kg/h), or 3) glucose-insulin added 30 IU NovoRapid® per litre,...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) carries a high risk of morbidity and mortality, with outcomes modified by treatment an incidence that may be increasing. We examined temporal changes in mortality during 2000-15 using nationwide healthcare registries.Patients incident AAV were identified International Classification Diseases Version 10 (ICD10) codes grouped according to inclusion year (Period 1: 2000-04, Period 2: 2005-09, 3: 2010-15). Log link...
Background Osteoporosis is a prevalent, under-diagnosed, and treatable disease associated with increased fracture risk. Bone mineral density (BMD) derived from cardiac CT may be used to determine rate. Purpose To assess the association between rate thoracic BMD CT. Materials Methods This prospective cohort study included consecutive participants referred for evaluation of ischemic heart September 2014 March 2016. End follow-up was June 30, 2018. In all participants, volumetric three...
Background. Aortoiliac screening before kidney transplantation is suggested by some guidelines to select patients for and assist surgical planning. We investigated the clinical outcomes of systematic aortoiliac disease in potential transplant candidates. Methods. In this observational study, 470 candidates underwent computed tomography angiography. Patients were characterized presence peripheral artery calcification iliac arteries arteries. The risk graft loss function at 1 y posttransplant...