A5004582793- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Otitis Media and Relapsing Polychondritis
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Cell Adhesion Molecules Research
- Renin-Angiotensin System Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cholinesterase and Neurodegenerative Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heparin-Induced Thrombocytopenia and Thrombosis
- PARP inhibition in cancer therapy
- Diabetic Foot Ulcer Assessment and Management
- Bipolar Disorder and Treatment
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Cardiac Fibrosis and Remodeling
- Complement system in diseases
Copenhagen University Hospital
2018-2024
Rigshospitalet
2018-2024
University of Copenhagen
2021
Addenbrooke's Hospital
2020
University of Cambridge
2020
Nordsjællands Hospital
2020
Gentofte Hospital
2015-2016
Abstract Background The significance of chronic kidney disease on susceptibility to COVID‐19 and subsequent outcomes remains unaddressed. Objective To investigate the association estimated glomerular filtration rate (eGFR) risk contracting adverse outcomes. Methods Rates hospital‐diagnosed were compared across strata eGFR based conditional logistic regression using a nested case–control framework with 1:4 matching patients diagnosed controls from Danish general population age, gender,...
Abstract Objective To examine whether patients with ANCA-associated vasculitis (AAV) have an increased risk of cardiovascular disease in the months prior to diagnosis AAV. Methods Using a nested case–control framework, granulomatosis polyangiitis and microscopic were identified through Danish Nationwide Registries from 1996 2021 matched 1:3 age- sex-matched controls without Each control was assigned same index date (date AAV diagnosis) as their corresponding case. Conditional logistic...
Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) have similar clinical manifestations, both presenting with rapid-onset nephrotic syndrome often amendable to treatment high-dose glucocorticoids. Recently, antinephrin antibodies (Ab) been reported be present in a subset of patients minimal as well FSGS recurrent massive proteinuria after kidney transplantation.1-3 Infusion Ab mice results subsequent lesions.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) carries a high risk of morbidity and mortality, with outcomes modified by treatment an incidence that may be increasing. We examined temporal changes in mortality during 2000-15 using nationwide healthcare registries.Patients incident AAV were identified International Classification Diseases Version 10 (ICD10) codes grouped according to inclusion year (Period 1: 2000-04, Period 2: 2005-09, 3: 2010-15). Log link...
Abstract Objectives To examine long-term cardiovascular outcomes and temporal trends among patients with ANCA-associated vasculitis (AAV) using Danish nationwide registries. Methods Using a cohort design, we examined granulomatosis polyangiitis (ICD-10: DM31.3) microscopic DM3.17) in Denmark from 1996–2018. Hazard ratios (HRs) of were compared between AAV age gender-matched controls. Counterfactual G-estimation HRs was performed to estimate 5-year absolute risks. Temporal obtained by...
The mortality following blood stream infection (BSI) and risk of subsequent BSI in relation to dialysis modality, vascular access, other potential factors has received relatively little attention. Consequently, we assessed these matters a retrospective cohort study, by use the Danish nation-wide registries.Patients more than 17 years age, who initiated between 1.1.2010 1.1.2014, were grouped according their modality access. Survival was modeled time-dependent Cox proportional hazard...
Background Evidence for pharmacogenetic risk stratification of angiotensin-converting enzyme inhibitor (ACEI) treatment is limited. Therefore, in a cohort ACEI-treated patients with congestive heart failure (CHF), we investigated the predictive value two scores that previously were found to predict ACEI efficacy ischemic disease and hypertension, respectively. Score A combined single nucleotide polymorphisms (SNPs) angiotensin II receptor type 1 gene (rs275651 rs5182) bradykinin B1...
Although kidney insufficiency has been shown to be associated with increased risk of myocardial injury, benefit coronary angiography (CAG) and revascularization remains uncertain, implications on management strategies outcomes. We aimed compare rates CAG subsequent cardiovascular outcomes in hospitalized patients injury dysfunction. Retrospective cohort study encompassing i.e. elevated troponin I or T an eGFR ≤60 ml/min/1.73 m2 identified between 2011 2021 Danish national registers. 30-day...
Chronic kidney disease (CKD) is mainly managed in primary care, but detailed information on these patients limited. This study describes CKD and the management referrals by general practitioners (GPs) Denmark order to identify opportunities for improved care. Patients with CKD, defined at least two abnormal estimated glomerular filtration rate (eGFR) or urinary albumin/creatinine ratio (UACR) measurements ≥90 days apart during 2019-2020, were followed until May 2023 utilizing electronic...
The first European Vasculitis Society (EUVAS) meeting report was published in 2017. Herein, we on developments the past 5 years which were greatly influenced by pandemic. adaptability to engage virtually, at this critical time society, embodies importance of networks and underscores role global collaborations. We outline state-of-the-art webinar topics, updates last years, proposals for agendas going forward. A host newly reported clinical trials is shaping practice steroid minimization,...
Objective Most angiotensin-converting enzyme inhibitors (ACEIs) are prodrugs activated by carboxylesterase 1 (CES1). We investigated the prognostic importance of CES1 gene (CES1) copy number variation and rs3815583 single-nucleotide polymorphism in among ACEI-treated patients with congestive heart failure (CHF). Methods Danish chronic CHF enrolled previously reported Echocardiography Heart Outcome Study were categorized according to their variants followed up for 10 years. Risk...
Variation in the carboxylesterase 1 gene (CES1) may contribute to efficacy of ACEIs. Accordingly, we examined impact CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Five these have previously been associated drug response or increased expression, i.e., copy number variation, variant duplicated high transcriptional activity, rs71647871, rs2244613, and rs3815583. Additionally, nine...
Acute kidney injury (AKI) has been associated with cardiovascular disease, but this is sparsely studied in non-selected populations and little attention to the effect age renal function. Using nationwide administrative data, we investigated hypothesis of increased one-year risk event or death AKI. In a cohort study, identified all admissions Denmark between 2008 2018. AKI was defined as ≥1.5 times increase from baseline peak creatinine during admission, dialysis. We excluded patients <50...
Objective: Abrupt decline in renal function following initiation of renin–angiotensin system inhibitor is associated with increased risk cardiovascular disease, but studies other antihypertensive drugs are sparse. We investigated the event plasma creatinine after initiating first-line treatment. Methods: In a nationwide cohort study, we identified adult Danish primary care patients either inhibitor, calcium channel blocker or thiazide, between 2008 and mid-2018. Patients prior end-stage...
A woman in her late sixties presented with severe hyponatremia and acute kidney injury (AKI) as consequence of psychogenic polydipsia urinary retention due to tract infection. Urinary catheterization promptly drained 5.5 L urine resulting polyuria, leading an initial swift raise plasma (P) sodium concentration, disregarding the course fluid resuscitation. After polyuric phase, normal range P-sodium levels were reestablished by oral water restriction. Treatment psychoactive drugs, e.g.,...
Diagnosis of anomalous intrathoracic lesions may be challenging and require a multidisciplinary approach. We present case granulomatosis with polyangiitis (GPA) clinically radiologically mimicking metastatic lung cancer bilateral pulmonary mass, mediastinal cervical lymph node involvement, pleural effusion. Surgical biopsy the thoracic lesion revealed necrotic granulomatous inflammation, final diagnosis was subsequently confirmed by kidney biochemical parameters. This illustrates how...
ABSTRACT Background Epidemiologic assessments of anti-glomerular basement membrane (GBM) disease have been challenging due to its rare occurrence. We examined changes in the incidence and outcomes from 1998 2018 using nationwide healthcare registries. Methods All patients with incident anti-GBM were identified International Classification Diseases, 10th Revision code DM31.0A. Controls matched 4:1 on birthyear sex exposure density sampling. Log link regression adjusted for time, age was...
Abstract Background and Aims Cardiovascular disease (CVD) is one of the leading causes death in patients with ANCA-associated vasculitis (AAV). However, current clinical guidelines, limited evidence available to support recommendation AAV-specific screening for cardiovascular comorbidities. This study reported prevalence electrocardiogram (ECG) abnormalities investigated associations between ECG fatal CVD a validated cohort AAV compared matched controls. Method Based on retrospective design,...
Abstract Background and Aims The effect of vaccinations against SARS-CoV-2 on risk infection subsequent adverse outcomes in patients with kidney dysfunction beyond end-stage disease remains uncertain. Based nationwide data from multiple health care registers, the study aims to evaluate vaccination rates associated mortality disease. Method A population-based retrospective cohort all Danish residents ≥18 years an eGFR ≤90 ml/min/1.73 m2 identified between February 1st 2021 June 27th 2022...
Abstract Background and Aims Infection due to the immunosuppressive treatment, is among most frequent causes of hospitalization death in patients with ANCA-associated vasculitis (AAV). Information on prevailing causal microbial aetiologies crucial for improving treatment prevention such events. Here we examined bacteriology, incidence, risk blood stream infections (BSIs) incident prevalent AAV patients, as compared general population. Method All data were retrieved from Danish nationwide...
Current guidelines provide limited evidence for cardiovascular screening in ANCA-associated vasculitis (AAV). This study aimed to investigate the prevalence of electrocardiogram (ECG) abnormalities and associations between no, minor or major ECG with mortality AAV patients compared matched controls.