A5072383325- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Dialysis and Renal Disease Management
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Cancer Treatment and Pharmacology
- Pain Management and Opioid Use
- Sleep and related disorders
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Chronic Kidney Disease and Diabetes
- Tryptophan and brain disorders
- Nausea and vomiting management
- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Neonatal Respiratory Health Research
- Health, psychology, and well-being
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Glioma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Pain Management Techniques
- Mobile Health and mHealth Applications
- Obesity, Physical Activity, Diet
- Central Venous Catheters and Hemodialysis
University of California, San Francisco
2016-2025
Cooper and Company (United States)
2011-2025
Unity Health System
2011-2024
The Milton H. Erickson Foundation
2024
Levine Cancer Institute
2021-2024
Wright Institute
2024
Cohen Children's Medical Center
2024
ChemoCentryx (United States)
2023
American Cancer Society
2011-2023
Institute on Aging
2023
In clinical practice, there is considerable variation in the timing of initiation maintenance dialysis for patients with stage V chronic kidney disease, a worldwide trend toward early initiation. this study, conducted at 32 centers Australia and New Zealand, we examined whether influenced survival among disease.We randomly assigned 18 years age or older progressive disease an estimated glomerular filtration rate (GFR) between 10.0 15.0 ml per minute 1.73 m2 body-surface area (calculated use...
The use of indomethacin as a tocolytic agent in pregnant women appears to be accompanied by low incidence neonatal complications. However, the effects have been studied primarily infants born after 32 weeks' gestation. This study was designed examine complications very premature infants.We identified 57 delivered at or before 30 gestation whose mothers had treated with for preterm labor and matched them not received indomethacin. two groups were sex, gestational age delivery (mean [+/- SD],...
OBJECTIVE. The goal was to explore barriers palliative care experienced by pediatric health providers caring for seriously ill children. METHODS. This study explored provider perceptions of end-of-life in an academic children's hospital, with the describing perceived children and their families. report focuses on responses nurses (n = 117) physicians 81). RESULTS. Approximately one half respondents reported 4 26 listed questionnaire as frequently or almost always occurring, that is,...
OBJECTIVES: To test whether the addition of melatonin to bright‐light therapy enhances efficacy in treating rest–activity (circadian) disruption institutionalized patients with Alzheimer's disease (AD). DESIGN: Randomized, controlled trial. SETTING: Two nursing homes San Francisco, California. PARTICIPANTS: Fifty subjects (mean age 86) AD. INTERVENTION: Experimental received 1 hour morning light exposure (≥2,500 lux gaze direction) Monday Friday for 10 weeks and 5 mg (LM, n=16) or placebo...
The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.To evaluate the efficacy effects methylprednisolone patients with at high risk function decline.An international, multicenter, double-blind, randomized clinical trial that enrolled 503 participants nephropathy, proteinuria greater than or equal to 1 g per day, estimated glomerular filtration rate (eGFR) 20 120 mL/min/1.73 m2 after least 3 months optimized background care from 67...
In the 330-patient ADVOCATE trial of avacopan for treatment antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 group and 4.1 prednisone (P = 0.029) at week 52. This new analysis examines results patient subgroup with severe insufficiency enrollment into trial, i.e., eGFR ≤20 m2.eGFR was determined baseline over course trial. Changes were...
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The Plasma Exchange (PLEX) and Glucocorticoids (GC) in Severe AAV (PEXIVAS;NCT00987389) trial was the largest first to enroll participants with DAH requiring mechanical ventilation. Objectives: Evaluate characteristics, treatment effects, outcomes for patients without DAH. Methods: PEXIVAS randomized 704 PLEX or no-PLEX reduced...
The neurohormone oxytocin is responsible for initiating childbirth and the let-down reflex in lactating women released during sexual orgasm. Oxytocin has been thought of as an affiliation hormone because research on nonhuman mammals demonstrated that it plays a key role initiation maternal behavior formation adult pair bonds. It speculated social stimuli may induce release make positive contact more rewarding. Data are presented from initial study to examine change plasma response standard...
To identify subgroups of outpatients with cancer based on their experiences the symptoms fatigue, sleep disturbance, depression, and pain; to explore whether patients in differed selected demographic, disease, treatment characteristics; determine two important patient outcomes: functional status quality life (QOL).Descriptive, correlational study.Four outpatient oncology practices northern California.191 receiving active treatment.Patients completed a demographic questionnaire, Karnofsky...
Breast-cancer-related lymphedema affects ∼25% of breast cancer (BC) survivors and may impact use the upper limb during activity. The purpose this study is to compare extremity (UE) impairment activity between women with without after BC treatment. 144 post treatment completed demographic, symptom, Disability Arm-Shoulder-Hand (DASH) questionnaires. Objective measures included Purdue pegboard, finger-tapper, Semmes-Weinstein monofilaments, vibration perception threshold, strength, range...
In a sample of family caregivers (FCs) patients with prostate cancer who were to begin radiation therapy (RT), the purposes determine prevalence and severity depression, anxiety, pain, sleep disturbance, fatigue; relationships among these symptoms between functional status quality life (QOL); evaluate for differences in QOL FCs low high levels symptoms; which factors predicted FCs' QOL.FCs recruited before initiated RT completed self-report questionnaires that evaluated demographic...
Anemia associated with chronic kidney disease (CKD) often requires treatment recombinant human erythropoietin (EPO). Hypoxia-inducible factor-prolyl hydroxylase inhibitors (PHIs) stimulate endogenous EPO synthesis and induce effective erythropoiesis by non-EPO effects. GSK1278863 is an orally administered small-molecule PHI.Multicenter, single-blind, randomized, placebo-controlled, parallel-group study.Anemic non-dialysis-dependent patients CKD stages 3-5 (CKD-3/4/5 group; n=70) anemic...
Background: Fatigue is a significant problem associated with radiation therapy (RT). Objective: This study examined how evening and morning fatigue changed from the time of simulation to 4 months after completion RT investigated whether specific demographic disease characteristics baseline severity symptoms predicted initial levels trajectories fatigue. Methods: Seventy-three women breast cancer completed questionnaires that assessed sleep disturbance, depression, anxiety, pain prior...
Pain, fatigue, sleep disturbance, and depression are common frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes this study were determine whether distinct latent classes patients with breast cancer (n = 398) could be identified based on their experience cluster, these differed demographic clinical characteristics variations cytokine genes associated class membership. Three identified: "all...
Background: Many debilitating symptoms arise from cancer and its treatment that are often unrelieved by established methods. Pranayama, a series of yogic breathing techniques, may improve cancer-related quality life, but it has not been studied for this purpose. Objectives: A pilot study was performed to evaluate feasibility test the effects pranayama on cancer-associated life. Design: This randomized controlled clinical trial comparing usual care. Setting: The conducted at university...
Although hope is an important resource for cancer patients, few studies include it as independent or dependent variable in quality-of-life research.The purposes of this study, a community-based sample were to evaluate the relationships between demographic and clinical characteristics, health status, hope, psychological distress, life satisfaction whether mediated relationship distress satisfaction.Participants (n = 194) completed questionnaire, single item self-assessed health, Herth Hope...
Direct-acting antivirals (DAAs) are curative in most persons with chronic hepatitis C virus (HCV) infection. However, high cost and concerns about adherence reinfection may present continued barriers to treatment, particularly for people who inject drugs (PWID).To understand changes assessments of treatment candidacy, given advances treatment.Clinicians attending the Liver Meeting® 2014 reported prescribing HCV past three years were invited complete a survey regarding decisions. Participants...