A5050027636- Dementia and Cognitive Impairment Research
- Healthcare Decision-Making and Restraints
- Geriatric Care and Nursing Homes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Alzheimer's disease research and treatments
- Pharmacological Effects and Toxicity Studies
- Circadian rhythm and melatonin
- Frailty in Older Adults
- Psychiatric care and mental health services
- Sleep and related disorders
- Advanced Neuroimaging Techniques and Applications
- Ethics and Social Impacts of AI
- Hip and Femur Fractures
- Migration, Aging, and Tourism Studies
- Palliative Care and End-of-Life Issues
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Neurological and metabolic disorders
- Bone health and osteoporosis research
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Emergency and Acute Care Studies
University of California, San Francisco
1995-2024
Mather LifeWays
2013-2020
Takeda (United States)
2013
Government of the Republic of Korea
2013
Jewish Home
1998-2010
Royal Netherlands Academy of Arts and Sciences
2008
Universidad Católica de Santa Fe
2002
Institute on Aging
1986-1994
Oregon Health & Science University
1992
National Institute on Aging
1986-1990
OBJECTIVES: To test whether the addition of melatonin to bright‐light therapy enhances efficacy in treating rest–activity (circadian) disruption institutionalized patients with Alzheimer's disease (AD). DESIGN: Randomized, controlled trial. SETTING: Two nursing homes San Francisco, California. PARTICIPANTS: Fifty subjects (mean age 86) AD. INTERVENTION: Experimental received 1 hour morning light exposure (≥2,500 lux gaze direction) Monday Friday for 10 weeks and 5 mg (LM, n=16) or placebo...
New brain imaging techniques may provide evidence for a biological basis severe psychiatric disorders. The authors used quantitative X-ray computed tomography (CT) to analyze the volume of 10 male patients with primary obsessive-compulsive disorder and healthy control subjects. Caudate nucleus in was significantly less than that subjects, but lenticular nuclei, third ventricle, lateral ventricle volumes did not differ between these two groups, no abnormal asymmetry bilateral structures...
Background: Disturbances in rest–activity rhythm are prominent and disabling symptoms Alzheimer's disease (AD). Nighttime sleep is severely fragmented daytime activity disrupted by multiple napping episodes. In most institutional environments, light levels very low may not be sufficient to enable the circadian clock entrain 24-hour day. The purpose of this randomized, placebo-controlled, clinical trial was test effectiveness morning bright therapy reducing (circadian) disruption...
We studied twelve men and six women with dementia of the Alzheimer type (DAT) healthy at intervals 6 months to 5 years. In male DAT patients, mean CT rates enlargement third ventricle total lateral ventricular volumes differed significantly from zero exceeded respective control values (p less than 0.05). The rate neuropsychological decline correlated or right ventricle. Women also had significant ventricles. dilatation discriminated patients controls.
Neuropsychiatric behaviors are common in people with Alzheimer's disease (AD) and make both professional lay caregiving difficult. Light therapy has been somewhat successful ameliorating disruptive behaviors. This randomized trial tested the effects of morning or afternoon bright light exposure compared usual indoor on presence, frequency, severity, occupational disruptiveness neuropsychiatric nursing home residents AD. was administered for 1 hr daily (Monday-Friday) 10 weeks. The...
BACKGROUND : Medicare claims as the basis for health condition adjustments is becoming a method of choice in capitation reimbursement. A recent study has found that claims‐based beneficiary classification Alzheimer's disease produces lower prevalence estimates and higher average costs than previous healthcare cost studies this population. These sets differ data sources, period length, their specification dementia. OBJECTIVES Participants Disease Demonstration (MADDE) provide sample persons...
Background Disturbances in rest-activity rhythm are prominent and disabling symptoms Alzheimer's disease (AD). Nighttime sleep is severely fragmented daytime activity disrupted by multiple napping episodes. In most institutional environments, light levels very low may not be sufficient to entrain the circadian clock 24-hour day. Method The purpose of this randomized clinical trial was test effectiveness timed bright therapy reducing (circadian) disruption institutionalized patients with AD....
Objective (1) To establish the range of cerebral atrophy across adult age spectrum in optimally healthy, rigorously evaluated individuals. (2) determine, spectrum, relation gender and (as measured by ventricular enlargement) to cognitive function. Design Cross‐sectional comparison gender. Setting Ambulatory research unit. Participants Sixty‐four healthy men (mean ± SD = 49 18 yr) 43 women (51 volunteers enrolled a longitudinal study aging. The population was selected for optimal health; all...
Background: As people live longer, there is increasing potential for mental disorders to interfere with testamentary distribution and render older more vulnerable “undue influence” when they are making a will. Accordingly, clinicians dealing the of will be called upon increasingly advise courts about person's vulnerability undue influence.Method: A Subcommittee IPA Task Force on Testamentary Capacity Undue Influence undertook establish consensus definition influence provision guidelines...
Quantitative CT demonstrated increased CSF and 3rd ventricular volumes, decreased gray matter white volume, in older (greater than 45 years) Down's syndrome (DS) adults with dementia as compared younger DS adults. Serial studies repeated after periods of up to 2 years significant progressive cerebral atrophy. Older without dementia, but cognitive decline, did not show atrophy young subjects. These results suggest brain must be present accompany subjects, despite the presence Alzheimer's...
We measured monoamine metabolites and biopterin in the CSF of 37 patients with dementia Alzheimer type (DAT), or without extrapyramidal signs, 14 age-matched healthy controls. Compared concentrations DAT controls, homovanillic acid (HVA) were significantly decreased signs (EDAT). 3-methoxy-4-hydroxy-phenethyleneglycol 5-hydroxyindoleacetic did not differ among these groups. Age at onset was positively correlated HVA (r = 0.49, p less than 0.05). The two groups extent ventricular dilation as...
Three pairs of twins, each with proved monozygosity, were shown to be discordant for dementia the Alzheimer's type and have remained periods 8 11 years. Dementia was demonstrated by history; serial clinical examinations; measurements cerebral glucose utilization using positron emission tomography ventricular volumes rates change quantitative computed tomography; neuropsychological tests. The results these measures showed no evidence abnormality in any unaffected twin. DNA markers from...
Abnormalities in calcium homeostasis have been reported Alzheimer's disease (AD) and the neurofibrillary tangle disorders of amyotrophic lateral sclerosis parkinsonism-dementia occurring Pacific. In order to more fully evaluate physiology AD, we analyzed size pineal choroid plexus calcifications, using X-ray computed tomography, 23 patients with probable AD 18 healthy age-matched control subjects. The area occupied by calcification was measured from hard copies data two independent observers...