A5041368557- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Geriatric Care and Nursing Homes
- Renal Diseases and Glomerulopathies
- Palliative Care and End-of-Life Issues
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Pharmacological Effects and Toxicity Studies
- Central Venous Catheters and Hemodialysis
- Renal Transplantation Outcomes and Treatments
- Grief, Bereavement, and Mental Health
- Folate and B Vitamins Research
- Healthcare innovation and challenges
- Potassium and Related Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Economic and Financial Impacts of Cancer
- Sodium Intake and Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal and Vascular Pathologies
- Diabetes Management and Education
- Cardiac Health and Mental Health
The George Institute for Global Health
2013-2024
UNSW Sydney
2018-2024
Concord Repatriation General Hospital
2014-2023
IP Australia
2022
Boehringer Ingelheim (Sweden)
2022
Christchurch Hospital
2022
The University of Sydney
2010-2018
St. George Hospital
2018
George Institute for Global Health
2014
Royal Prince Alfred Hospital
2014
Survival, symptom burden, and quality of life (QOL) are uncertain for elderly patients with advanced CKD managed without dialysis. We examined these outcomes in renal supportive care dialysis (RSC-NFD) those planned or commencing
ABSTRACT Background Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic disease (CKD) type 2 diabetes two phase 3 outcome trials. The addition to standard of care, on the progression Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates effect finerenone adults CKD without diabetes. Methods FIND-CKD (NCT05047263 EU CT 2023-506897-11-00) is randomized, double-blind, placebo-controlled trial...
Increasing numbers of elderly patients face decisions about the management end-stage kidney disease. Improved understanding contemporary patient and practice factors influencing prognosis may assist decision making for individual their care providers. This is a prospective registry study using multivariable proportional hazards models. A total 1781 aged ≥75 years at dialysis initiation recorded in ANZDATA, Australia New Zealand renal replacement registry, between January 2002 December 2005....
OBJECTIVE To determine the incidence of and factors associated with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 in people diabetes. RESEARCH DESIGN AND METHODS We identified diabetes EXamining ouTcomEs chroNic Disease 45 Up Study (EXTEND45), a population-based cohort study (2006–2014) that linked Sax Institute’s to community laboratory administrative data New South Wales, Australia. The outcome was first eGFR measurement recorded during follow-up period....
Nephrologists often face difficult decisions when recommending dialysis or non-dialysis (supportive) care for elderly patients, given the uncertainty around survival and burden of dialysis. Discrete choice experiments (DCEs) mimic real-world through simultaneous consideration multiple variables. We aimed to determine relative influence patient characteristics on recommendations. conducted a DCE among Australasian nephrologists consisting 12 scenarios two patients (described in terms age,...
To use linked routinely-collected health data to estimate diabetes prevalence and incidence in an Australian cohort of adults aged ≥45 years, examine risk factors associated with incident disease.The EXamining ouTcomEs chroNic Disease the 45 Up Study (EXTEND45) is a study that combines baseline questionnaire responses from population-based (2006-2009, n = 267,153) multiple databases up December 2014. Among participants ≥1 result for any laboratory test, status was determined sources...
Chronic kidney disease (CKD) and diabetes are the major causes of death disability worldwide. They associated with high health service utilization persisting over many years. Their slow progression wide clinical variation make them eminently suitable for study in population-based cohorts. However, current understanding their prevalence, incidence, is largely based on studies conducted populations.This aims to establish a novel link between an existing cohort (the 45 Up Study) routinely...
To determine risk factors for incident chronic kidney disease (CKD) in a large population-based cohort.This prospective opt-in cohort study is based on the 45 and Up Study, where New South Wales residents aged ≥45 years were randomly sampled from Services Australia database agreed to complete Study baseline questionnaire have their responses linked health data routinely collected databases. The primary outcome was development of CKD, defined as eGFR < 60 mL/min/1.73 m2 . CKD incidence...
Abstract Objective We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together a lifestyle program reduced the two years by 40% compared to alone. To develop personalized approach treatment, we aimed explore prognostic model for incident and investigate biomarkers predictive effect. Design Model development in 783 impaired glucose tolerance but not from T4DM; multicenter, 2-year trial Testosterone vs placebo. External validation performed 236...
To explore the quality of deaths in an acute hospital under a nephrology service at two teaching hospitals Sydney with renal supportive care services over time.Retrospective chart review all years 2004, 2009 and 2014 St George Hospital (SGH) Concord Repatriation General Hospital. Domains assessed were recognition dying, invasive interventions, symptom assessment, anticipatory prescribing, documentation spiritual needs bereavement information for families. End-of-life plan (EOLCP) use was...