A5101783088- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Multiple Myeloma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Healthcare and Venom Research
- Reproductive System and Pregnancy
- Neurological Disorders and Treatments
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Genomics, phytochemicals, and oxidative stress
- Chronic Lymphocytic Leukemia Research
Wuhan Children's Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Shanghai Changzheng Hospital
2022-2025
Second Military Medical University
2014-2024
Changhai Hospital
2012-2024
Capital Medical University
2010-2022
Ningxia Medical University
2022
Southern Medical University
2022
Army Medical University
2022
Gansu Provincial Hospital
2022
ABSTRACT Background Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic disease (CKD) type 2 diabetes two phase 3 outcome trials. The addition to standard of care, on the progression Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates effect finerenone adults CKD without diabetes. Methods FIND-CKD (NCT05047263 EU CT 2023-506897-11-00) is randomized, double-blind, placebo-controlled trial...
Objectives: This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants a multicenter, randomized, open, controlled trial. Methods: The were randomized into low-dose high-dose groups, serum calcium, inorganic phosphorus 25-hydroxyvitamin levels detected thrice 4 months. Infants infected with monitored symptoms including fever, cough wheezing. Pathogen treatment also evaluated. Results: Of 121 cases total, 78 43 infection occurred...
Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, they cause debilitating side effects, which limit the use of these compounds. In past decade, many researchers have attempted find so-called dissociated GCs that separate distinct transactivation and transrepression activities. Anti-inflammation is a result glucocorticoid receptor (GR)-mediated in some tissues, similar their effects; therefore, goal discover compound has anti-inflammatory properties, but lacks...
Abstract Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Frequent tumor recurrence after surgery related to its poor prognosis. Although gene expression signatures have been associated with outcome, molecular basis of HCC not fully understood, and there no method predict using peripheral blood mononuclear cells (PBMCs), which can be easily obtained for prediction in clinical setting. Methods According microarray analysis results, we constructed a...
Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis mRNAs and miRNA expression profiles.The mRNA profiles GSE79973 GSE67354 downloaded from Gene Expression Omnibus were used analyze differentially expressed genes (DEGs) DE-miRNAs among tissues normal tissues. Then, targets predicted...
Abstract The precise role of transforming growth factor (TGF)-β signaling in head and neck squamous cell carcinoma (SCC) is not yet fully understood. Here, we report generation an inducible head- neck-specific knockout mouse model by crossing TGF-β receptor I (Tgfbr1) floxed mice with K14-CreERtam mice. By applying tamoxifen to oral cavity the induce Cre expression, were able conditionally delete Tgfbr1 epithelia. On tumor induction 7,12-dimethylbenz(a)anthracene (DMBA), 45% conditional...
Non-alcoholic fatty liver disease (NAFLD) is a major public health concern worldwide. The aim of the present study was to observe effect diosgenin on NAFLD and investigate underlying mechanisms. Diosgenin treatment increased phosphorylation AMP-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) in HepG2 cells. significantly inhibited high glucose (HG)-induced triglyceride (TG) accumulation sterol regulatory element‑binding protein-1c (SREBP-1c) mRNA increase cells, which were...
"CLO25-072: A Multicenter, Randomized, Controlled, Non-Inferiority Study of Narlumosbart Compared With Denosumab in the Treatment Bone Disease Patients Multiple Myeloma" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Background: Large-cell neuroendocrine lung carcinoma (LCNEC) is a rare subtype of cancer that lacks standard treatment at present. Purpose: This study aimed to investigate the status, failure pattern, survival outcome, and gene expression profile LCNEC in China. Design: real-world retrospective combined with transcriptome sequencing tumors. Methods: Patients newly diagnosed Beijing Chest Hospital from 2015 2022 were retrospectively reviewed. Treatment, analyzed. Transcriptome non-small-cell...
To assess the efficacy and safety of acetyl-L-carnitine (ALC) on diabetic peripheral neuropathy compared with methylcobalamin (MC).This was a multicenter, randomized, parallel-group, double-blind, double-dummy, positive-controlled, non-inferior phase II clinical trial. Diabetic patients abnormal nerve conduction test results were randomized in 1:1 ratio to receive oral ALC 500 mg t.i.d. or MC 0.5 for 24 weeks. The symptom score, disability score neurophysiological parameters measured during...
Matrix metalloproteinase-1 (MMP-1) has been identified as an important participant in tumor invasion, metastasis and angiogenesis. The purpose of the present study was to investigate effects epidermal growth factor receptor (EGFR) localization lipid rafts on signaling pathways involved regulation MMP-1 expression SiHa cells, a cervical cancer cell line. EGFR activation by EGF specifically induced at both messenger RNA protein levels. Additionally, it observed that localized rafts,...
Abstract Introduction Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for compounds improve effect of classic steroids. We sought unravel how plant-original compound, ginsenoside Rh1, potentiates dexmethasone (DEX)’s potential anti-inflammation properties. Methods Ginsenoside Rh1 combined with DEX was applied short-term and long-term treatment protocol inflammation. Its mechanism on explored. In addition, side-effect induced by...
Abstract Oxidative stress, which occurs after ultraviolet (UV) radiation, usually results in Glucocorticoid (GC) resistance and the subsequent development of skin inflammation. One approach to protecting against UV radiation is use antioxidants. The ginsenoside Rg1 a novel natural antioxidant isolated from medicinal plant Panax ginseng C.A. Mey . We demonstrated that UVB exposure exacerbated inflammation reduced both level glucocorticoid receptor (GR) efficacy dexamethasone (Dex) human...
Abstract Introduction Glucocorticoid (GC) therapy is the main treatment for systemic lupus erythematosus (SLE). However, some patients are resistant to these agents. Abnormalities of glucocorticoid receptor (GR) seem be related steroid resistance. This study evaluated GRs in T lymphocytes and monocytes SLE by flow cytometry (FCM) using a monoclonal antibody (mAb) FITC-Dex probes. Methods Thirty-five with before 27 age- sex-matched normal controls were studied. Disease activity scores...
A hypoxic microenvironment may induce angiogenesis and promote the development of hepatocellular carcinoma (HCC). The aim this study was to evaluate whether ursodeoxycholic acid (UDCA) inhibit HCC cell-induced possible mechanisms.
Icariin is the major active constituent of Epimedii Herba. Our recent study showed that icariin displayed anti-inflammatory potential. One novel derivate 3,5,7-Trihydroxy-4′-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT). Little known about ICT's pharmacological activities. In our study, properties ICT were evaluated. Murine RAW264.7 cells and C57BL/6J mice stimulated by lipopolysaccharide (LPS) was used as in vitro vivo inflammatory model, respectively. data (1–100 μg/mL) significantly...