A5033946832- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Venous Thromboembolism Diagnosis and Management
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cancer Mechanisms and Therapy
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Molecular Communication and Nanonetworks
- Plant Pathogens and Fungal Diseases
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Cancer Treatment and Pharmacology
- Antioxidant Activity and Oxidative Stress
- Crystallization and Solubility Studies
- Energy Efficient Wireless Sensor Networks
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
Nantong University
2016-2025
Affiliated Hospital of Nantong University
2016-2025
Guangdong Polytechnic Normal University
2025
Guangdong Academy of Medical Sciences
2022-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2022-2024
Peking Union Medical College Hospital
2023-2024
Shenyang Agricultural University
2023
Changsha University of Science and Technology
2022-2023
Ministry of Transport
2022-2023
Despite the high therapeutic response achieved with B-cell maturation antigen (BCMA)-specific chimeric receptor (CAR) T-cell therapy in relapsed and refractory multiple myeloma (R/R MM), primary resistance relapse exist single-target immunotherapy. Here, we design bispecific BC19 CAR T cells targeting BCMA/CD19 evaluate antimyeloma activity vitro vivo. Preclinical results indicate that specifically recognize target antigens, mediate selective killing of BCMA or CD19-positive cancer cells....
Clinical trials have confirmed that chimeric antigen receptor (CAR) T cell therapies are revolutionizing approaches for treating several relapsed or refractory hematological tumors. Cytokine release syndrome (CRS) is an adverse event with high incidence during CAR-T treatment. A further understanding of the characteristics and related risk factors CRS important effective management. total 142 patients acute lymphocyte leukemia (ALL), lymphoma, multiple myeloma (MM) received lymphodepletion...
In this paper, wideband and high efficiency millimeter-wave circular Airy orbital angular momentum (OAM) beams, which have desired multiplexing OAM modes, directions, beam numbers, are generated by the proposed three metal layer transmission metasurfaces (TMSs) with size 12λ 0 ×12λ based on Airy-OAM phase superposition method.The measured results indicate non-diffracting propagation distance 31λ , autofocusing property, aperture 13.1%, 16.8% (28 GHz-33 GHz).The design method can be used for...
Bladder cancer (BC) is the most common of urinary bladder and upper tract, in which clinical management limited. AURKA (aurora kinase A) has been identified as an oncogene development; however, its potential role underlying mechanisms progression BC remain unknown. In this study, we evaluated Aurora A (AURKA) expression patient samples by performing gene profiling, found that levels were significantly higher tissues than normal tissues. Increased was strongly associated with stage grade....
"CLO25-072: A Multicenter, Randomized, Controlled, Non-Inferiority Study of Narlumosbart Compared With Denosumab in the Treatment Bone Disease Patients Multiple Myeloma" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Citrus fruits exhibit vivid color and are favored extensively. However, the biochemical molecular mechanism of Reticulata Blanco coloring, especially effect transplantation on is unclear. Herein, RNA-Seq carotenoids profiling were applied to investigate Orah mandarin coloring. Transplantation induces fruit shallowing, Ca2+ ACC level declining IAA increasing. induced variation in skin pulp carotenoids, mainly β-citraurin as one important pigments citrus peel. 2253 up-regulated genes, 1103...
To investigate the relative expression level and clinical significance of
Deep convolutional neural networks (DCNNs) have recently emerged as a promising approach for computer vision tasks with many new DCNN architectures proposed to further improve their performance. However, the significant computation workload limits deployment of such on embedded devices. Research accelerating inference usually employs field-programmable gate arrays (FPGAs) due programmability. hardware efficiency and reconfigurability do not often receive sufficient attention. This paper...
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive form of mature commonly found in elder males, but its genetic features are poorly understood. In this study, we had performed target-sequencing 360 lymphoma-related genes on 76 PT-DLBCL patients with median age 65 (33-89). Our data provide comprehensive understanding the landscape mutations small subset PT-DLBCL.
Abstract Background Individuals with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs) are at risk of developing venous thromboembolism (VTE), a serious complication. There is no established clinical model for predicting VTE in the Chinese population. We develop new assessment (RAM) IMiD-associated MM patients. Methods retrospectively selected 1334 consecutive patients IMiDs from 16 medical centers China and classified them randomly into derivation validation cohorts. A...
Elevated IL-17 produced by Th17 cells was reported to promote myeloma cell growth and inhibit immune function in multiple (MM). IL-17A also MM through receptors enhance adhesion bone marrow stromal (BMSCs). Spleen tyrosine kinase (Syk) influences survival migration. Herein we aimed investigate whether Syk involved the regulative role of viability cells.Cell determined using CCK8 assay. The production cytokine including evaluated with ELISA. Western blotting assay used determine protein...
This study aimed to investigate whether annexin A7 (ANXA7) could promote the cell cycle, proliferation and adhesion-mediated drug resistance (CAM-DR) of multiple myeloma (MM) cells by up-regulating division cycle 5-like (CDC5L).As a result, ANXA7 expression was increased in serum MM patients CDC5L also lines.ANXA7 overexpression promoted U266 RPMI8226 cells.The nuclear antigen (PCNA), KI67, cyclin dependent kinase 1 (CDK1) cyclinB1 transfected consistent with changes cycle.In co-culture...
Multiple myeloma (MM) is an incurable plasma cell malignancy. Aberrant activation of the Hedgehog (Hh) and NF-κB signaling pathways observed in MM plays a pivotal role development by promoting growth, survival, drug resistance. In this study, we found that Sonic Hh (SHh) ligand bone marrow microenvironment responsible for enhancement activity lines NCI-H929 U266. Notably, discovered regulates through its classical pathway (SHh/PTCH1/SMO/GLI1) cells. Meanwhile, non-classical SMO recruitment...
Due to the safety, convenience and efficacy of subcutaneous administration bortezomib (scBor), it is becoming increasingly common treat multiple myeloma (MM) using this treatment method. The current retrospective study suggested a lower incidence peripheral neuropathy (PN) outcomes superior following with scBor combined thalidomide dexamethasone (VTD) in MM when compared intravenous Bor (ivBor) treatment. data 81 patients from Affiliated Hospital Nantong University between September 2011...
Abstract Background Helicobacter pylori ( H. ) infection of gastric epithelial cells induces inflammatory response. Outer membrane proteins (OMPs), Type 4 secretion system (T4SS) encoded by cag PAI, and the effector protein CagA are involved in pathogenesis . possesses a gene encoding LuxS which synthesizes AI‐2, quorum sensing signal molecule. The aim this study was to investigate role AI‐2 expression virulence factors response (AGS) induced Materials Methods Δ luxS mutant constructed,...