A5100352086- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Chronic Myeloid Leukemia Treatments
- Galectins and Cancer Biology
- Radiomics and Machine Learning in Medical Imaging
- Coronary Interventions and Diagnostics
- Total Knee Arthroplasty Outcomes
- Cardiac Imaging and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Kruppel-like factors research
- Orthopaedic implants and arthroplasty
- Facial Trauma and Fracture Management
- Lymphatic System and Diseases
- Esophageal Cancer Research and Treatment
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
- Ovarian cancer diagnosis and treatment
Jinhua Central Hospital
2025
Hebei Medical University
2024
Peking University Cancer Hospital
2015-2024
Peking University
2015-2024
Fujian Medical University
2015-2023
Shanghai Center For Bioinformation Technology
2012-2023
Zhejiang University
2023
Mianyang Third People's Hospital
2023
Third People's Hospital of Hangzhou
2023
Peking Union Medical College Hospital
2022
BACKGROUND Tumor progression in patients with esophageal precancerous lesions (EPLs) or early carcinoma (EEC) is typically confined both extent and location. Prompt effective intervention significantly improves treatment outcomes prognosis for these individuals. AIM To determine the effect of endoscopic submucosal dissection (ESD) on efficacy, serum tumor markers (STMs), 6-month postoperative recurrence rate either EPL EEC. METHODS This study initially enrolled 120 EEC, who were admitted...
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome cancer may provide new approaches targets anticancer therapy. The aim this study is to examine relationship between expression RhoT1, Smad4 p16 survival in patients analysis showed that high cytoplasmic levels tissues had significantly negative correlation lymph node (LNM) (P = 0.017, P 0.032, 0.042, respectively). However, no...
Helicobacter pylori colonises the stomach of approximately 50% global population. Cytotoxin-associated gene A protein (CagA) is one important virulent factors responsible for increased inflammation and increases risk developing peptic ulcers gastric carcinoma. The cytokine interleukin-6 (IL-6) has particularly roles in malignant transformation intestinal epithelial cells as it upregulated H. pylori-infected mucosa. In this study, we investigated underlying mechanisms CagA-induced IL-6...
Abstract The goal of this study was to evaluate the feasibility detecting Helicobacter pylori clarithromycin resistance in gastric mucosa using amplification refractory mutation system combined with quantitative real‐time PCR (ARMS‐PCR). Gastric mucosal specimens (150) were collected from patients who unsuccessfully treated for H. pylor i eradication. Each specimen divided into 2 samples. One sample used extract genomic DNA and detect any gene mutations H . produced by ARMS‐ PCR. Sequencing...
Limited studies have reported the association between dietary patterns and risk of Helicobacter pylori (H pylori) infection. The purpose this study was to evaluate relationship H infection in a Chinese population ages from 45 59 years. We performed cross-sectional examination associations 3014 adults years Hangzhou city, Zhejiang province, China. Dietary intake assessed through semi-quantitative food frequency questionnaire (FFQ). diagnosed using C-urea breath test. Multivariable logistic...
INTRODUCTION: Convolutional neural network during endoscopy may facilitate evaluation of Helicobacter pylori infection without obtaining gastric biopsies. The aim the study was to evaluate diagnosis accuracy a computer-aided decision support system for H. (CADSS-HP) based on convolutional under white-light endoscopy. METHODS: Archived video recordings upper with examinations performed at Sir Run Shaw Hospital (January 2019–September 2020) were used develop CADSS-HP. Patients receiving...
BACKGROUND About 10%-31% of colorectal liver metastases (CRLM) patients would concomitantly show hepatic lymph node (LNM), which was considered as sign poor biological behavior and a relative contraindication for resection. Up to now, there’s still lack reliable preoperative methods assess the status nodes in with CRLM, except pathology examination after AIM To compare ability mono-exponential, bi-exponential, stretched-exponential diffusion-weighted imaging (DWI) models distinguishing...
The optimal treatment for elderly patients with acute myeloid leukemia (AML) remains a great challenge. Establishing more feasible, acceptable, accessible and safe strategy is urgently needed. We conducted prospective study of 23 (median age, 68 years; range, 60 to 87 years) newly diagnosed AML evaluate the efficacy toxicity decitabine plus granulocyte colony-stimulating factor priming, low-dose aclarubicin, cytarabine (DCAG) chemotherapy combined HLA-mismatched stem cell...
Objective . The diagnosis of primary malignant melanoma the esophagus (PMME) before treatment is essential for clinical decision‐making. However, PMME may be misdiagnosed as esophageal squamous cell carcinoma (ESCC) sometimes. This research aimed at devising a radiomics nomogram model CT distinguishing from ESCC. Methods In this retrospective analysis, 122 individuals with proven pathologically ( n = 28) and ESCC 94) were registered our hospital. PyRadiomics was applied to derive features...
Abstract Background Helicobacter pylori ( H. ) infection of gastric epithelial cells induces inflammatory response. Outer membrane proteins (OMPs), Type 4 secretion system (T4SS) encoded by cag PAI, and the effector protein CagA are involved in pathogenesis . possesses a gene encoding LuxS which synthesizes AI‐2, quorum sensing signal molecule. The aim this study was to investigate role AI‐2 expression virulence factors response (AGS) induced Materials Methods Δ luxS mutant constructed,...
Biobanking has become an increasingly important activity to provide resources for medical research support. In China, establishing and maintaining a biobank have been the latest trend in hospital. However, biobanking is still emerging young field terms of professionalization professionalism. The development faces many challenges involving skills, identities, norms, values associated with becoming part professional group. professionals (i.e., biobankers) are most factor driving force toward...
Isolated coronoid process fractures are uncommon, and iatrogenic isolated extremely rare. This case describes a displaced fracture of an thought to be due excessive force applied by dentist that had been overlooked left untreated for about month. The patient was woman in her late 50’s she undergone molar extraction. Her confused symptoms trismus, pain, facial oedema with the complex tooth extraction procedure. Following cone-beam computed tomography (CBCT) scan we showed mandibular on right...
The anterior cruciate ligament (ACL) is commonly injured. stress distribution in the ACL key for understanding its function and injury mechanism, as well developing optimal surgical reconstruction protocols. In this study, a three-dimensional subject-specific finite element model of human was developed. Bony geometries were reconstructed from CT scan images, while geometry orientation fiber bundles measured via mechanical digitizer. A transversely isotropic, hyperelastic, nearly...
Helicobacter pylori (H. pylori) may enter into host cells, maybe as a facultative intracellular pathogen. This study aims to reveal the roles of internalized H. in bacterial pathopoiesis. Transmission electron microscopy was used observe invasion pylori. Invasion rates (two standard strains and 43 clinical strains) were examined by gentamicin assay. The cagA, cagE vacA genes detected PCR. cagA 3'region (cagA-EPIYA) each strain sequenced. secretion IL-8 from AGS cells activity NF-κB induced...
Introduction. Helicobacter pylori is associated with gastrointestinal disease, most notably gastric cancer. Cytotoxin-associated antigen A (CagA), an important virulence factor for H. pathogenicity, induces host cells to release inflammatory factors, especially interleukin-8 (IL-8). The mechanism by which C-terminal CagA IL-8 production has been studied extensively, but little known about the role of N-terminus.Aim. To investigate effect CagA303-456aa (a peptide in N-terminal CagA) on...
Background: The number of coronary chronic total occlusion (CTO) patients with left ventricular (LV) systolic dysfunction is significant, but the clinical outcomes these are rarely reported. present retrospective cohort study aimed to investigate long-term successful recanalization vs. optimal medical therapy (MT) for CTOs in preserved and impaired LV function. Methods: A 1,895 were stratified according Of these, 1,420 (74.9%) ejection fraction (LVEF) >45% 475 (25.1%) LVEF ≤45%...
Background: To date, the benefit of successful revascularization chronic total occlusions (CTOs) on prognosis remains uncertain, and there is a paucity data impact for CTO patients long-term cardiovascular survival. This study aimed to investigate survival with unsuccessful in large cohort patients. Methods: There were 1,655 consecutive at least one included grouped into ( n = 591) 1,064). Propensity score matching (PSM) was carried out balance clinical angiographic characteristics. Cardiac...
Helicobacter pylori harbors a dipeptide (Dpp) transporter consisting of substrate-binding protein (DppA), two permeases (DppB and C), ATPases (DppD F). The Dpp is responsible for the transportation dipeptides short peptides. We found that its expression important growth H . To understand role in pathogenesis , virulence factors -induced IL-8 production were investigated H. wild-type isogenic mutants. CagA was downregulated, while type 4 secretion system (T4SS) components upregulated DppA...
Helicobacter pylori causes gastric infections in more than half of the world's population. The bacterium's survival stomach is mediated by abundant production urease to enable acid acclimation. In this study, our transcriptomic analysis demonstrated that expression structural proteins, UreA and UreB, induced autoinducer AI-2 H. pylori. We also found orphan response regulator HP1021 downregulated AI-2, resulting induction expression. represses directly binding promoter region ureAB, ranging...
Purpose: Helicobacter pylori is associated with the development of gastrointestinal diseases. However, its eradication challenged by an increased rate drug resistance. AlgC and GalU are important for synthesis UDP-glucose, which a substrate lipopolysaccharide (LPS) in H. . In this study, we investigated role UDP-glucose intrinsic resistance Methods: Gene knockout strains or complementation strains, including Δ algC , galU galE hp0045 / * were constructed Hp26695 ; also two clinical...