A5101689145- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Regulation of Appetite and Obesity
- Esophageal and GI Pathology
- Cytokine Signaling Pathways and Interactions
- Greenhouse Technology and Climate Control
- Agriculture Sustainability and Environmental Impact
- COVID-19 and Mental Health
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- Healthcare professionals’ stress and burnout
- Cancer-related Molecular Pathways
- Hormonal Regulation and Hypertension
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Motor Control and Adaptation
- MicroRNA in disease regulation
Peking University Cancer Hospital
2014-2025
Peking University
2014-2025
Xi'an Jiaotong University
2018-2024
Sichuan University
2022-2024
State Key Laboratory of Hydraulics and Mountain River Engineering
2022-2024
University of Electronic Science and Technology of China
2023
Jining Medical University
2023
Sichuan Cancer Hospital
2023
Zhengzhou University
2019-2022
Shanxi Medical University
2022
Abstract Epithelial–mesenchymal transition (EMT) plays a crucial role in hepatocellular carcinoma (HCC) progression. Hypoxia and excessive transforming growth factor-β (TGF-β) have been identified as inducers target for EMT HCC. Here, we show hypoxia inducible factor-1α (HIF-1α) TGF-β form feed-forward loop to induce HCC cells. Further mechanistic study indicates under both stimulation, Smad PI3K-AKT pathways are activated. We sanguinarine, natural benzophenanthridine alkaloid, impairs the...
Visual input could benefit balance control or increase postural sway, and it is far from fully understanding the effect of visual stimuli on stability its underlying mechanism. In this study, different inputs complexity was examined by analyzing mean velocity (MV), SD, fuzzy approximate entropy (fApEn) center pressure (COP) signal during quiet upright standing. We designed five exposure conditions: eyes-closed, eyes-open (EO), three virtual reality (VR) scenes (VR1-VR3). The VR were a...
Hepatocellular carcinoma (HCC) is a biologically complex disease. Combination chemotherapy good strategy after surgery treatment. In this study, we report that berberine combined with HMQ1611 (BCH) had synergistic effect on the HCC. Our findings concluded BCH showed inhibition HCC proliferation and colony formation, which attributed to cell cycle arrest by at G1 phase through impairing expression of cyclinD1, cyclinE, cdc2 downregulated phosphorylation Akt, mTOR, ERK. Moreover, negatively...
The efficacy of surgery alone for patients with locally advanced esophageal cancer (EC) is still unsatisfactory. Presently, induction therapy followed by the standard treatment. Preoperative chemotherapy (CT) and chemoradiation (CRT) are proven effective therapies; however, few sample studies have addressed these treatments, thus, their superiority remains uncertain. We performed a systemic review meta analysis to test hypothesis that CRT prior could improve survival compared CT alone.A...
Abstract Aims/Introduction Studies have found that a plant‐based diet was associated with lower risk of type 2 diabetes, but evidence is scarce on such associations in China. The aim this study to investigate whether related diabetes among Chinese adults. Materials and Methods A total 37,985 participants were enrolled from the Henan Rural Cohort Study. An overall index (PDI) created by assigning positive reverse scores 12 commonly consumed food groups. Multivariate logistic regression models...
Non-small cell lung cancer (NSCLC) accounts for 80% of cancers, and squamous carcinoma (SQCC) is one the main types. Advances in treatment SQCC are lacking when compared to adenocarcinoma. The early-stage surgery. However, factors affecting efficacy surgical treatments remain unclear. In this study, we examined significance commonly used diagnostic markers p63, p40, cytokeratin (CK)5/6 prognosis.Seventy-six cases (N0) were obtained from our database (January 2000 December 2009). Tissue...
The incidence of synchronous and metachronous multiple primary lung cancers (MPLCs) has been increasing recently. new multidisciplinary classification adenocarcinoma TNM Classification Lung Cancer (7(th) edition, 2009), have improved the understanding MPLC. Most researchers recommend that surgical therapy should be actively pursued if patient's physical condition function permit it a complete cure can achieved. However, few studies reported long-term efficacy treatment for MPLC, which we...
Abstract Breast cancer is one leading cause of death in females, especially triple‐negative breast (TNBC). Hypoxia a key feature to tumour progression driven by hypoxia‐inducible factor (HIF)‐1α. The aim investigate the mechanism HIF‐1α and signal transducer activator transcription‐3 (STAT3) interaction discover compound disrupt cells. regulation pattern STAT3 was analysed hypoxic TNBC cells patient samples. effects natural alkaloid, sanguinarine, on colocalization were evaluated vitro mouse...
Non-small cell lung cancer (NSCLC) accounts for 80 % of cancers, and adenocarcinoma (ADC) is one the main types NSCLC. Although there are several studies on relationship between ADC immunohistochemical diagnostic markers (thyroid transcription factor 1 (TTF-1) Napsin A) survival, some aspects those could be improved. We examined significance commonly used markers, including TTF-1, A, CK7, in prognosis early-stage ADC. One hundred nineteen cases (N0) were selected from prospective database...
Abstract Objective: The aim of the study was to determine if early menarche is associated with an increased risk type 2 diabetes mellitus (T2DM) in rural Chinese women and estimate proportion that can be attributed adiposity. Methods: A total 15,346 postmenopausal were enrolled this study. Logistic regression restricted cubic spline analysis performed relationship between age at T2DM. Mediation used investigate whether association mediated by body mass index (BMI). Results: After adjusting...
Faced with severe global shortage of water and soil resources, studies on the integrated effect nitrogen tomato cultivation are urgently needed for sustainable agriculture. Two successive greenhouse experiments three irrigation regimes (1, 2/3, 1/3 full irrigation) four levels 1/3, 0 nitrogen) were conducted; plant growth, fruit yield quality surveyed; comprehensive net profit evaluated. The results show that deficit decreased evapotranspiration while increasing production efficiency...
Abstract Purpose The aims of this study were to evaluate the effect age at menarche (AM) on type 2 diabetes mellitus (T2DM) and assess whether fasting plasma glucose (FPG) homeostasis model assessment (HOMA) index responses AM menopause status interact in Chinese rural adults. Methods A cross-sectional, population-based including 23 138 participants was performed. Logistic regression multivariable linear performed investigate relationship between status. Generalized used calculate...
Abstract Background Surgery is an important component in the treatment of esophageal cancer. For patients not eligible for R0 resection, defined as locally advanced unresectable cancer, a new approach to transform cancer into resectable state by preoperative treatment. However, chemo/radiation unsatisfactory. Therefore, aim this study was assess safety and efficacy chemo/radiotherapy combined with programmed cell death protein 1 (PD‐1) inhibitor transformation Methods Patients were evaluated...