A5101558434- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Receptor Mechanisms and Signaling
- Mycobacterium research and diagnosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Head and Neck Surgical Oncology
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Health Systems, Economic Evaluations, Quality of Life
- Protein Kinase Regulation and GTPase Signaling
- Tuberculosis Research and Epidemiology
- Bone and Joint Diseases
- Cardiovascular Disease and Adiposity
- TGF-β signaling in diseases
- Hematological disorders and diagnostics
- Tannin, Tannase and Anticancer Activities
- Hip disorders and treatments
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Liver physiology and pathology
Jinan University
2022-2024
Nanjing University of Chinese Medicine
2023
Jiangsu Province Hospital
2023
Wuhan University
2022
Dalian Medical University
2014-2021
First Affiliated Hospital of Dalian Medical University
2020-2021
Huazhong University of Science and Technology
2021
Affiliated Hospital of Southwest Medical University
2017-2018
National Cancer Registration Service
2018
The First People’s Hospital of Lianyungang
2016
Abstract The development of RNA aptamers/fluorophores system is highly desirable for understanding the dynamic molecular biology RNAs in vivo. Peppers-based imaging systems have been reported and applied mRNA living cells. However, need to insert corresponding aptamer sequences into target relatively low fluorescence signal limit its application endogenous imaging. Herein, we remolded original Pepper developed a tandem array inert (iPepper) turn-on system. iPepper allows efficient selective...
Bone morphogenetic protein-4 (BMP4), a member of the transforming growth factor β (TGF-β) family factors, is activated and increased under hypoxic conditions, which plays an important role in progression pulmonary arterial hypertension (PAH). Previous studies have shown that BMP4 involved regulation proliferation, differentiation, migration apoptosis various cell types. However, precise mechanisms artery smooth muscle cells (PASMCs) PAH are still incompletely understood. It has been reported...
Abstract Background In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients and without type 2 diabetes mellitus. Methods A 2015 CTOs were stratified. Diabetic (n = 755, 37.5%) non-diabetic 1260, 62.5%) subjected to or CTO-PCI. We performed a propensity score matching (PSM) balance baseline characteristics. comparison major adverse cardiac events (MACE) was done evaluate long-term...
The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. β 1 subunits, 1C 1A , that contain variant domains differentially affect proliferation; inhibits whereas promotes it. We investigated the ability of to modulate integrin-mediated signaling events proliferation survival in Chinese hamster ovary stable lines expressing either human or . different cytodomains did not association with endogenous α 2 V 5 subunits adhesion fibronectin...
Abstract As a key virulence factor for persistent colonization, urease B subunit (UreB) is considered to be an ideal vaccine antigen against Helicobacter pylori infection. However, the role and molecular mechanisms of UreB involved in immune microenvironment dysregulation still remain largely unknown. In present study, we evaluated effects on macrophage activation found that induced PD-L1 accumulation bone marrow-derived macrophages (BMDMs). Co-culture assays further revealed UreB-induced...
The aim of this study was to corroborate the hypothesis that Tao-Hong-Si-Wu Decoction (THSWD) affects steroid-induced avascular necrosis femoral head (SANFH) by regulating hypoxia-inducible factor 1α (HIF-1α) pathway. Forty-eight New Zealand rabbits were randomly divided into a normal control group (NC group), model (SANFH THSWD group, and dimethyloxalylglycine (DMOG group). Rabbits in SANFH injected with both horse serum methylprednisolone. gavaged addition receiving same treatment as...
This study aimed to address the dilemma of low peripheral blood-derived mesenchymal stromal cell (PBMSC) activity and reduced phenotype in bone or cartilage tissue engineering. Rat PBMSCs (rPBMSCs) were obtained by density gradient centrifugation, characteristics confirmed flow cytometry (FCM) multi-differentiation potential induction experiments. Cell growth curve, viability experiments, clone formation experiments performed...
Endothelial cell insulin resistance may be partially responsible for the higher risk of atherosclerosis and cardiovascular disease in populations with type 2 diabetes mellitus (T2DM).A genome-wide association study revealed a significant between ATPase plasma membrane Ca 2+ transporting 1 (ATP2B1) gene T2DM two community-based cohorts from Korea Association Resource Project.However, little is known about implication ATP2B1 on T2DM.In present study, we investigated role endothelial...
Background: The number of coronary chronic total occlusion (CTO) patients with left ventricular (LV) systolic dysfunction is significant, but the clinical outcomes these are rarely reported. present retrospective cohort study aimed to investigate long-term successful recanalization vs. optimal medical therapy (MT) for CTOs in preserved and impaired LV function. Methods: A 1,895 were stratified according Of these, 1,420 (74.9%) ejection fraction (LVEF) >45% 475 (25.1%) LVEF ≤45%...
Abstract A three‐dimensional alginate‐coated scaffold (GAIS) was constructed in the present study to showcase multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and investigate role mechanism by which Icariin (ICA)/stromal cell‐derived factor (SDF‐1α)/PBMSCs promote damaged articular repair. In addition, ability ICA, combination with SDF‐1α, migration proliferation validated through utilization CCK‐8 experiments. The ICA SDF‐1α inhibited differentiation PBMSCs...
Background: To date, the benefit of successful revascularization chronic total occlusions (CTOs) on prognosis remains uncertain, and there is a paucity data impact for CTO patients long-term cardiovascular survival. This study aimed to investigate survival with unsuccessful in large cohort patients. Methods: There were 1,655 consecutive at least one included grouped into ( n = 591) 1,064). Propensity score matching (PSM) was carried out balance clinical angiographic characteristics. Cardiac...
c-Myc (Myc) is a well-known transcription factor that regulates many essential cellular processes. Myc has been implicated in regulating anti-mycobacterial responses. However, its precise mechanism modulating mycobacterial immunity remains elusive. Here, we found secreted Rv1579c (early target with molecular weight 12 kDa, named EST12) protein, encoded by virulent Mycobacterium tuberculosis ( M.tb ) H37Rv region of deletion (RD)3, induces early expression and late degradation protein....
Abstract Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it necessary to differentiate from these tumors. Patient concerns: A 42-year-old man presented with complaints epistaxis for 1 day. The patient had undergone endoscopic resection neoplasm right nasal passage at another hospital 35 months before was...
Background: The number of coronary chronic total occlusion (CTO) patients with renal insufficiency is huge, and limited data are available on the impact long-term clinical outcomes in CTO patients. We aimed to investigate percutaneous intervention (PCI) vs. medical therapy (MT) according baseline function. Methods: In study population 2,497, 1,220 underwent PCI 1,277 received MT. Patients were divided into four groups based function: group 1 [estimated glomerular filtration rate (eGFR) ≥ 90...
An amendment to this paper has been published and can be accessed via the original article.
Aims: Success of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in decrease myocardial viability by percutaneous coronary intervention (PCI) with that optimal medical therapy (OMT) alone patients chronic total occlusion (CTO) artery. Methods and results: The risks benefits both options (PCI OMT) were listed CTO decision aid (DA). Eligible participants detected invasive angiography (ICA) or computed tomography (CCTA) divided into PCI OMT groups...