A5058692411- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Metabolism, Diabetes, and Cancer
- Ion Transport and Channel Regulation
- Endoplasmic Reticulum Stress and Disease
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- IL-33, ST2, and ILC Pathways
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Bone Tissue Engineering Materials
- Gout, Hyperuricemia, Uric Acid
- Eicosanoids and Hypertension Pharmacology
Ingenierie des Materiaux polymeres
2025
Sichuan University
2010-2025
Affiliated Hospital of Southwest Medical University
2017-2025
First Affiliated Hospital of Sichuan Medical University
2016-2024
Beijing Chao-Yang Hospital
2021-2024
Capital Medical University
2021-2024
Xuzhou Medical College
2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
Taizhou People's Hospital
2024
The identification of drug-target interactions (DTIs) is an essential step in drug discovery. In vitro experimental methods are expensive, laborious, and time-consuming. Deep learning has witnessed promising progress DTI prediction. However, how to precisely represent protein features a major challenge for Here, we developed end-to-end framework called BINDTI based on bi-directional Intention network. First, encoded with graph convolutional networks its 2D molecular obtained by SMILES...
Abstract Atherosclerosis is a multifactorial disease of the vasculature, and shear stress crucial regulator its process. Disturbed flow promotes atherosclerotic effects, while laminar has protective action on endothelium. Hippo/YAP major cascade that senses various mechanical cues mediates expression pro-inflammatory genes. However, mechanism modulating transcription factor YAP in response to different patterns blood remains unclear. In this study, we provide evidence modulates activity via...
Reconstruction of osteoporotic bone defects is a clinical problem that continues to inspire the design new materials.
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus (DM) and closely associated to programmed cell death. However, the complex mechanisms necroptosis, an alternative death pathway, in DKD pathogenesis are yet be elucidated. This study indicates that necroptosis involved induced by high glucose (HG) both vivo vitro. HG intervention led activation RIPK1/RIPK3/MLKL signaling, resulting renal tissue proinflammatory streptozotocin/high-fat diet- (STZ/HFD-)...
The co-administration of RDDG and RMDG NPs simultaneously inhibits the tumor growth cancer-related inflammation.
Abstract Hyperglycaemia-induced endothelial dysfunction is a key factor in the pathogenesis of diabetic microangiopathy and macroangiopathy. STING, which newly discovered regulator innate immunity, has also been reported to play an important role various metabolic diseases. However, STING diabetes-induced cell unknown. In this study, we established macroangiopathy mouse model by streptozotocin (STZ) injection combined with high-fat diet (HFD) feeding glucotoxicity high glucose (HG)-treated...
Tight junction is a structural constitution in cell-cell adhesion and play an important role the maintenance of permeability integrity normal epithelial cell barrier. The protein encoded by Claudin 1 (CLDN1), member claudin family, integral membrane component tight strands. CLDN1 has been proved to regulate proliferation metastasis multiple tumors, but little known about its esophageal squamous carcinoma (ESCC). Here, we found that was aberrantly increased ESCC tissues lines, mainly...
Cardiovascular disease remains a leading cause of death and disability worldwide. Heart failure (HF) is the end stage various cardiovascular diseases. Despite recent advancements in understanding HF pathogenesis treatment, prognosis patients with poor. Inflammation key player development HF, its role has been extensively studied. associated elevated risk adverse prognosis. Targeting cardiac inflammation suggested as promising treatment strategy for HF. However, almost all clinical trials on...
Background: Nonalcoholic steatohepatitis (NASH) has recently garnered increased attention due to immune infiltration.However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study explore its relationship with infiltration and regulatory mechanisms.Methods: We employed weighted correlation network analysis (WGCNA) construct a gene co-expression aimed at identifying key genes associated progression.Our further analyses included differential...
Background Diabetic kidney disease (DKD) is a leading cause of chronic disease, and while lifestyle interventions like intermittent fasting have shown promise in treating diabetes, the impact modified alternate-day (MADF) on DKD not well understood. This study aimed to explore MADF’s effects db/db mice, model for condition, investigate its underlying mechanisms. Methods We implemented an MADF regimen mice high-fat diet, measuring blood glucose, body weight, renal function at various times....
Photoconversion of waste plastics into valuable CO and CH3COOH represents a ground‐breaking strategy for addressing plastic pollution issues. However, this process currently encounters significant challenges, primarily due to the limitation catalyst activity difficulty in breaking C–C bonds. Herein, we present novel approach that integrates multi‐step charge transfer pathways with photothermal‐driven reactions improve photoconversion efficiency. By incorporating Bi0/Bi3+ metal as an electron...