A5101592519- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Gastrointestinal Tumor Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Inflammasome and immune disorders
- Gastroesophageal reflux and treatments
- Kruppel-like factors research
- Endometrial and Cervical Cancer Treatments
- PI3K/AKT/mTOR signaling in cancer
- Peripheral Artery Disease Management
- Sunflower and Safflower Cultivation
- Microscopic Colitis
- Hemophilia Treatment and Research
- Inflammatory Biomarkers in Disease Prognosis
- Ultrasound in Clinical Applications
- Gastric Cancer Management and Outcomes
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
First Affiliated Hospital of Zhengzhou University
2024
Beijing Hospital of Traditional Chinese Medicine
2024
Capital Medical University
2024
Second Affiliated Hospital of Inner Mongolia Medical University
2024
University of South China
2024
Southwest University
2022-2023
City University of Hong Kong
2022
Peking University First Hospital
2020-2021
Peking University
2020-2021
Southwest Medical University
2014-2020
Platelets play a fundamental role in maintaining hemostasis and have been shown to participate hematogenous dissemination of tumor cells. Abundant platelets were detected the microenvironment outside blood vessel, thus, platelet -tumor cell interaction bloodstream may regulating primary growth metastasis initiation. However, it is unclear that depletion affects vessel structure dynamics. Using thrombocytopenia induction two different tumor-bearing mouse models, tissues performed by...
Aim To evaluate the efficacy and safety of Jinghua Weikang Capsule (JWC) combined with amoxicillin-furazolidone triple/quadruple therapies in rescue treatment drug-resistant H. pylori infection. Methods Patients who failed eradication therapy at least once were enrolled randomly assigned into four groups (1:1:1:1), as follows: The control group received 20 mg rabeprazole, 1,000 amoxicillin, 220 bismuth potassium citrate, 100 furazolidone twice daily (b.i.d.) for 14 days; Group A 240 JWC...
Tight junction is a structural constitution in cell-cell adhesion and play an important role the maintenance of permeability integrity normal epithelial cell barrier. The protein encoded by Claudin 1 (CLDN1), member claudin family, integral membrane component tight strands. CLDN1 has been proved to regulate proliferation metastasis multiple tumors, but little known about its esophageal squamous carcinoma (ESCC). Here, we found that was aberrantly increased ESCC tissues lines, mainly...
Few study has been done to evaluate the stability and superiority of normalizers for serum microRNA (miRNA) in cardiovascular disease. Therefore, aim this is assess suitability several common (miR-16, SNOU6, 5S, miR-19b, miR-24, miR-15b, let 7i) disease.We evaluated seven circulating miRNAs as reference genes blood samples from patients with disease [heart failure (HF) hypertension] healthy people. Stability was quantified by combining BestKeeper, NormFinder comparative delta Cq analysis.A...
MicroRNA (miR)-503 is involved in the regulation of malignant phenotype multiple tumor types, and has been proven to be a novel diagnostic therapeutic target; however, its function mechanisms action have not yet fully elucidated esophageal squamous cell carcinoma (ESCC). In current study, we detected miR‑503 expression by RT‑qPCR found that was increased ESCC, but negatively correlated with lymph node metastasis, TNM stage differentiation. Functionally, confirmed inhibited proliferation...
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed side population (SP) from esophageal squamous carcinoma (ESCC) lines, but the role underlying mechanism of ESCC remain unclear. In this study, observed up-regulated miR-141 down-regulated SP isolated could stimulate self-renewal ability carcinogenicity cells, promote invasion migration. overexpression expression significantly reduced. We also that...
Abstract Background The currently recommended quadruple regimens for Helicobacter pylori infection might not be appropriate every patient, especially in elderly patients or those with multiple comorbidities. Objective To evaluate the efficacy and safety of rabeprazole‐amoxicillin dual therapy H ‐positive Methods From November 2013 to May 2017, clinical data ≥60 years old comorbidities were collected reviewed. All given rabeprazole 10 mg three times a day amoxicillin 1000 thrice (RA therapy)...
Abstract Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, ischemia-reperfusion injury been shown to limit therapeutic effects vascular recanalization. Protein HAX-1 reported as pro-survival protein that plays an important role in various disorders, particularly association with nervous system. However, mechanisms IR have yet be elucidated. So, we aimed investigate effect on microglial pyroptosis...
Vascular endothelial growth factor (VEGF) plays a key role in regulating angiogenesis, and this process is largely dependent on the newly formed extracellular matrix (ECM). The levels of vitronectin (VN) are increased patients with various cardiovascular diseases. A for VN VEGF-induced angiogenesis has not been previously reported. We tested hypothesis that regulates VEGFR-2 activation via effects αvβ3, thus contributing to angiogenesis.We used 3-dimensional assay, examined VEGF-mediated...
The aim of this study was to determine whether a new MRI-based staging system for osteonecrosis the knee in pediatric patients could be used with an acceptable level intra- and interobserver agreement.We conducted retrospective analysis MRI studies performed single institution between April 1994 July 2003. Knee identified 168 children primary diagnosis hematologic malignancy. This substantial number prompted us design use patients. To assess reliability two observers using system, they...
This study was performed to compare the effects of high carbohydrate and lipid diets reception on growth, feed utilization glucose homeostasis genetically improved farmed tilapia Oreochromis niloticus. Three isonitrogenous (ca 30.2% protein) were formulated with different levels starch lipid: control (CON, 24.2% 6.57% lipid), diet (HCD, 33.8% 6.91% (HLD, 24.0% 16.5% lipid). Tilapia juveniles (initial mean body weight: 32.2 ± 0.2 g/fish) randomly divided into 12 rectangular tanks (250 L) 20...
<b><i>Background:</i></b> The flowers of <i>Carthamus tinctorius</i> L. are widely used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent <i>C. flowers, is known for its multiple biological activities. present study investigated effects HSYA on angiogenesis vitro a mouse hindlimb ischemia model. <b><i>Methods:</i></b> Using human umbilical...
Abstract A complete understanding and good adherence are crucial for successful Helicobacter pylori eradication. Proper frequency of reminders might be helpful to both doctors patients maintain during treatment. The study was evaluate the influence an intensive follow‐up system based on a clinical database H . eradication therapy. total 196 eligible were equally randomly divided into group control group. Both groups administered bismuth‐containing quadruple therapy 14 days. Patients in...
Ulcerative colitis (UC) is an inflammatory bowel disease that predominantly impacts the colon, typically starting in rectum. A significant characteristic of UC its propensity to affect distal...
Coagulation factor V (FV) plays a key role in hemostasis, is present plasma and platelets, has both pro- anticoagulant properties; however, the contribution of platelet-derived FV to arterial thrombosis remains undetermined.Using transgenic mice with various levels gene expression that was restricted or roles platelet were evaluated regulation activation. Mice higher exhibited faster thrombotic occlusion carotid artery after injury compared lower levels. Infusion platelets into undetectable...
Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and destabilizing blood vessels. Collateral artery growth (arteriogenesis) is key adaptive response to arterial occlusion. It unknown whether destabilization vessels by Ang-2 can affect arteriogenesis modulate mononuclear cell function. This study aimed investigate effects on collateral growth.Hindlimb ischaemia model was produced C57BL/6 mice femoral ligation. Blood flow...
Factor V (FV) is a critical component in the blood coagulation cascade. In patients, FV inhibitors ihave been reported association with malignancy. found plasma and platelet, which exhibited physical functional differences. However, functions of cancer progression remains poorly understood. Whether determinant metastatic potential circulating tumor cells, we evaluated impact different levels platelets on hematogenous mouse pulmonary metastasis model. The role platelet-derived was using...
The glucuronidation process has been regarded as the key elimination for toxic bile acids. UDP-glucuronosyltransferase (UGT) 1A3 is one important metabolizing enzyme involved in this process.To evaluate inhibition of UGT1A3 by scutellarein which an herbal ingredient using vitro method, trying to indicate possibility toxicity due accumulation acids.Due difficulty gain standards biles acids' glucuronides, recombinant UGT1A3-catalyzed 4-methylumbelliferone (4-MU) reaction was employed profile...