A5022959036- Pharmacogenetics and Drug Metabolism
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
- Autoimmune and Inflammatory Disorders Research
- Phosphodiesterase function and regulation
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Mechanical Circulatory Support Devices
- Drug Transport and Resistance Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Bowel Disease
Duke University
2021-2025
University of Illinois Chicago
2014
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting articular joints and skeletal muscle. To assess the role of cytokines upon muscle strength in RA, we developed an vitro tissue-engineered human model (myobundle). Myobundles were generated using primary cells from vastus lateralis RA patients age-matched healthy controls. myobundles more sensitive to 5 ng/mL IFN-γ, exhibiting reduced contractile force altered contraction kinetics. Addition IL-6 with or without IFN-γ led...
Inflammatory bowel disease (IBD) is a condition of chronic immune response and inflammation the gastrointestinal tract. Most women with IBD are affected during their reproductive years, untreated can have detrimental maternal fetal outcomes. In recent many biological therapies including anti-TNF agents (infliximab, adalimumab, certolizumab) been developed for treatment IBD. An increasing number patients treated these pregnancy. Sporadic reports suggest an absence negative pregnancy outcomes...
Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily targeting the joints. Autoreactive immune cells involved in RA affect other tissues, including skeletal muscle. Patients with experience diminished physical function, limited mobility, reduced muscle pain, and increased mortality. To explore impact of on muscle, we engineered electrically responsive, contractile human constructs (myobundles) using primary isolated from vastus lateralis 11 patients (aged 57-74) 10 aged...
The glucuronidation process has been regarded as the key elimination for toxic bile acids. UDP-glucuronosyltransferase (UGT) 1A3 is one important metabolizing enzyme involved in this process.To evaluate inhibition of UGT1A3 by scutellarein which an herbal ingredient using vitro method, trying to indicate possibility toxicity due accumulation acids.Due difficulty gain standards biles acids' glucuronides, recombinant UGT1A3-catalyzed 4-methylumbelliferone (4-MU) reaction was employed profile...