A5101631656- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gut microbiota and health
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Cardiac Ischemia and Reperfusion
- Nutrition and Health in Aging
- Gout, Hyperuricemia, Uric Acid
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic Associations and Epidemiology
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Ferroptosis and cancer prognosis
- Clostridium difficile and Clostridium perfringens research
- Lipoproteins and Cardiovascular Health
Peking University First Hospital
2010-2024
Peking University
2010-2024
Singapore University of Technology and Design
2024
Peking University International Hospital
2021-2023
First Affiliated Hospital of Zhengzhou University
2022-2023
China Telecom
2022
Qingdao University
2014-2022
Affiliated Hospital of Qingdao University
2014-2022
Fujian University of Traditional Chinese Medicine
2022
Northwest A&F University
2022
Background and aims This study aimed to evaluate the efficacy safety of vonoprazan tetracycline (VT) dual therapy as first-line treatment for Helicobacter pylori infection in patients with penicillin allergy. Methods In this randomised controlled trial, treatment-naïve adults H. allergy were 1:1 receive either open-label VT (vonoprazan 20 mg two times per day+tetracycline 500 three a day) or bismuth quadruple (BQT; lansoprazole 30 day+colloidal 150 day+metronidazole 400 14 days. The primary...
BACKGROUND Helicobacter pylori (HP), the most common pathogenic microorganism in stomach, can induce inflammatory reactions gastric mucosa, causing chronic gastritis and even cancer. HP infection affects over 4.4 billion people globally, with a worldwide rate of up to 50%. The multidrug resistance poses serious challenge eradication. It has been de-monstrated that compared bismuth quadruple therapy, Qingre Huashi decoction (QHD) combined triple therapy exhibits comparable eradication rates...
More than 30-40% of uric acid is excreted via the intestine, and dysfunction intestinal epithelium disrupts excretion. The involvement gut microbiota in hyperuricemia has been reported previous studies, but changes mechanisms immunity are still unknown.This study developed a urate oxidase (Uox)-knockout (Uox-/-) mouse model for using CRISPR/Cas9 technology. lipometabolism was assessed by measuring biochemical indicators. Furthermore, 4-kDa fluorescein isothiocyanate-labeled dextran used to...
OBJECTIVE This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi [SZ-A]) in treatment type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS was a multicenter, randomized, double-blind, double-dummy, parallel controlled noninferiority clinical trial that conducted for 24 weeks. A total 600 patients were randomly allocated SZ-A group (n = 360) or acarbose 240). The primary end point change glycosylated hemoglobin (HbA1c) compared with baseline. In addition,...
Background Helicobacter pylori (HP) is considered a leading risk factor for gastric cancer (GC). The aim of this article to conduct bibliometric and visual analysis assess scientific output, identify highly cited papers, summarize current knowledge, explore recent hotspots trends in HP/GC research. Methods A bibliographic search was conducted on October 24, 2023, retrieve relevant studies research between 2003 2022. terms were attached HP GC. main data from the Web Science Core Collection...
Background: The association between serum ferritin (SF) and in-hospital mortality in sepsis-associated acute kidney injury (SAAKI) remains unclear. study explored the relationship SF SAAKI patients. Methods: A retrospective cohort was conducted using data from Medical Information Mart for Intensive Care-IV2.2 database. primary outcome all-cause, mortality. Multivariable adjusted Cox regression models were utilized to determine hazard ratio (HR) 95% confidence interval (95% CI). natural...
Aim To evaluate the efficacy and safety of Jinghua Weikang Capsule (JWC) combined with amoxicillin-furazolidone triple/quadruple therapies in rescue treatment drug-resistant H. pylori infection. Methods Patients who failed eradication therapy at least once were enrolled randomly assigned into four groups (1:1:1:1), as follows: The control group received 20 mg rabeprazole, 1,000 amoxicillin, 220 bismuth potassium citrate, 100 furazolidone twice daily (b.i.d.) for 14 days; Group A 240 JWC...
Propofol is an intravenous sedative hypnotic agent of which the growth-inhibitory effect has been reported on various cancers. However, roles propofol in endometrial cancer (EC) remain unclear. This study aimed to explore effects EC vitro and vivo. Different concentrations were used treat Ishikawa cells. Colony number, cell viability, cycle, apoptosis, migration, invasion analyzed by colony formation, MTT, flow cytometry, Transwell assays. In addition, pcDNA3.1-Sox4 Sox4 siRNA plasmids...
Breast cancer is a common malignant tumor with high incidence of recurrence and metastasis. It has been reported that propofol certain anti-breast effects, but the intrinsic molecular mechanism remains unclear. This study investigated effect on breast MCF-7 cells its possible regulatory mechanisms. were treated by propofol, then effects cell growth epithelial-mesenchymal transition (EMT) studied. We subsequently testified whether miR-21 was downstream effector propofol. As result, repressed...
The treatment of Helicobacter pylori (H. pylori) infection is a challenge for those who cannot use amoxicillin.To evaluate the eradication rate and adverse effects vonoprazan tetracycline dual therapy as first-line rescue regimens used in special populations with penicillin allergy or failed previous amoxicillin-containing therapies.Patients enrolled were H. pylori-positive selected conditions: (1) allergic to penicillin, either naïve had before; (2) therapies. All patients accepted 14-day...
Abstract Regulatory B cells (Bregs) are critical in maintaining self-tolerance. Their role dermatomyositis (DM), an autoimmune disease characterized by inappropriate regulation of hyperactivated and T cells, has not been clearly defined. In the current study, we performed flow cytometry analysis studied CD19 + CD24 high CD38 Breg subpopulations blood samples from 30 patients with DM, 37 diseased controls 23 healthy controls. A significant decrease was observed frequency Bregs DM compared to...
Aim: The aim of this study is to identify potential serum biomarkers Alzheimer’s disease (AD) for early diagnosis and evaluate these markers on a large cohort. Methods: We performed two-dimensional difference gel electrophoresis compare the AD patients normal controls. Western blot or enzyme-linked immunosorbent assay (ELISA) was used expression levels proteins. Results: In study, total 13 differentially expressed proteins were identified. Among them, 2 (inter-alpha-trypsin inhibitor heavy...
Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients type 2 diabetes. Methods. This clinical trial enrolled 38 who were randomized into two groups (SZ-A: 23; acarbose: 15) treated for 24 weeks. Patients staffs masked to treatment assignment throughout study. The primary outcome measures glycated hemoglobin (HbA1c) 1-hour 2-hour postprandial fasting plasma glucose levels from baseline end treatment. Analysis included all...
Abstract Background The currently recommended quadruple regimens for Helicobacter pylori infection might not be appropriate every patient, especially in elderly patients or those with multiple comorbidities. Objective To evaluate the efficacy and safety of rabeprazole‐amoxicillin dual therapy H ‐positive Methods From November 2013 to May 2017, clinical data ≥60 years old comorbidities were collected reviewed. All given rabeprazole 10 mg three times a day amoxicillin 1000 thrice (RA therapy)...
Background: Fuzheng Nizeng Decoction (FZNZ) has a history of decades in gastric precancerous lesions (GPL) treatment, which shown clear clinical efficacy. Blocking GPL is key measure to reduce the incidence cancer (GC). Therefore, we aim investigate mechanism FZNZ-induced ferroptosis and endoplasmic reticulum (ER) MNNG-induced lesion (MC) cells, been rarely studied Traditional Chinese Medicine (TCM). Methods: First, CCK8 lactate dehydrogenase assays were conducted study potential effect FZNZ...
Autophagy has been demonstrated to play important roles in the infection and pathogenesis of many viruses. We previously found that porcine parvovirus (PPV) can induce autophagy placental trophoblast cells (PTCs), but its underlying mechanism not yet fully revealed. In this study, we showed PPV inhibited activation mTORC1 promoted expression Beclin 1 LC3II PTCs. Treatment with a mTOR activator LC3II, as well formation, reduced viral replication PPV-infected Furthermore, inhibition AMPK...
Helicobacter pylori (H. pylori) infects half of the human population globally. Eradication rates with triple or quadruple therapy have decreased owing to increasing rate antibiotic resistance. Jinghua Weikang capsule (JWC) is first and most popular Chinese patent medicine approved by state for treatment gastritis peptic ulcers caused H. infection in China. Previous studies found that JWC has a certain bactericidal effect on drug-resistant its major component, Chenopodium ambrosioides L....