A5044483026- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Cancer, Lipids, and Metabolism
- Mangiferin and Mango Extracts
- Renal Diseases and Glomerulopathies
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Bioactive natural compounds
Zunyi Medical University
2024
Chinese University of Hong Kong
2019
Peking University
2016-2018
Peking University First Hospital
2016-2018
Qufengtongluo (QFTL) decoction is an effective treatment for diabetic nephropathy (DN). However, the underlying molecular mechanism still unclear. In this study, we try to investigate whether QFTL acts via inhibiting PI3K/Akt signaling pathway. Twenty-four GK rats were randomly divided into 3 groups: blank group, sham-operated and group. After model establishment, in group given by gavage, while rest pure water. During 8-week intervention, 24 hr urinal protein was measured every 2-3 weeks....
Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients type 2 diabetes. Methods. This clinical trial enrolled 38 who were randomized into two groups (SZ-A: 23; acarbose: 15) treated for 24 weeks. Patients staffs masked to treatment assignment throughout study. The primary outcome measures glycated hemoglobin (HbA1c) 1-hour 2-hour postprandial fasting plasma glucose levels from baseline end treatment. Analysis included all...
Diabetic kidney disease (DKD) develops in approximately 40% of patients who are diabetic and results heavy economic burdens. In the present study, we hypothesized that latent TGF-β1 is able to protect against fibrosis inflammation via TGF-β/Arkadia/Smad7 pathways.