A5100341733- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Diagnosis and treatment of tuberculosis
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Cancer-related Molecular Pathways
- Infectious Diseases and Tuberculosis
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
Zhongshan Hospital
2010-2025
Fudan University
2014-2025
Shanghai Institute of Microsystem and Information Technology
2025
Chinese Academy of Sciences
2025
Zhejiang Chinese Medical University
2025
Anyang Hospital of Traditional Chinese Medicine
2024
Hunan Province Chest Hospital
2023-2024
Peking University
2006-2024
WuXi AppTec (China)
2021-2024
Peking University First Hospital
2023-2024
Abstract Background Cellular systems are highly dynamic and responsive to cues from the environment. function response patterns external stimuli regulated by biological networks. A protein-protein interaction (PPI) network with static connectivity is in sense that nodes implement so-called functional activities evolve time. The shift analysis essential for further understanding of molecular systems. Results In this paper, Time Course Protein Interaction Networks (TC-PINs) reconstructed...
Sterol-regulatory element binding protein 1 (SREBP1), an intracellular cholesterol sensor located in the endoplasmic reticulum, regulates by Insig-Srebp-Scap pathway. Over-expression of SREBP1 can cause dyslipidemia. regulate metabolic pathway, and then promote proliferation tumor cells. However, there is no relevant research metastasis invasion field colorectal cancer (CRC).Expression was manipulated CRC cell lines with low high level expression transfectiong plasmids containing gene, or...
Incorporation of next-generation sequencing (NGS) technology into clinical utility in targeted and immunotherapies requires stringent validation, including the assessment tumor mutational burden (TMB) microsatellite instability (MSI) status by NGS as important biomarkers for response to immune checkpoint inhibitors.We designed an assay, Cancer Sequencing YS panel (CSYS), applied algorithms detect five classes genomic alterations two features TMB MSI.By CSYS exhibited high sensitivity...
Background and aims This study aimed to evaluate the efficacy safety of vonoprazan tetracycline (VT) dual therapy as first-line treatment for Helicobacter pylori infection in patients with penicillin allergy. Methods In this randomised controlled trial, treatment-naïve adults H. allergy were 1:1 receive either open-label VT (vonoprazan 20 mg two times per day+tetracycline 500 three a day) or bismuth quadruple (BQT; lansoprazole 30 day+colloidal 150 day+metronidazole 400 14 days. The primary...
Aberrant expression of microRNA (miRNA) has been previously demonstrated to play an important role in a wide range cancer types and further elucidation its the mechanisms underlying tumorigenesis, anticarcinogenesis potential chemotherapeutics is warranted. We chose anti-benzo[ ]pyrene-7,8-diol-9,10-epoxide-transformed human bronchial epithelial cell line 16HBE-T study miRNAs involved anticarcinogenesis. In resveratrol-treated cells, we found that miR-622 was upregulated, whereas it...
// Zhiyuan Han 1 , Yanbin Zhang 2 Qiaoyuan Yang Binbin Liu Jianjun Wu Yajie 3 Chengfeng 4 and Yiguo Jiang State Key Laboratory of Respiratory Disease, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, P.R. China Department Pulmonary Tuberculosis, Chest Hospital, Pathology, Physiology Center Integrative Toxicology, Michigan East Lansing, MI, USA Correspondence to: Jiang, email: Keywords : CCNE1, lung cancer, miR-34a, miR-497 Received January 05, 2015 Accepted...
Abstract Background ATPase associated with a variety of cellular activities (AAA ATPase) family members are closely linked to tumor formation and progression. However, their roles in hepatocellular carcinoma (HCC) largely remain unclear. Methods Bioinformatic analyses public databases were used excavate the potential AAA ATPases that may contribute HCC, thyroid hormone receptor interactor 13 (TRIP13) was selected following researches because its most prominently differential expression....
The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2'-O positions of viral RNA cap, using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here small molecule compounds, which putatively bind to SAM-binding site MTase inhibit its function, were identified by virtual screening. In vitro methylation experiments demonstrated significant inhibition 13 these with most potent compound displaying sub-micromolar inhibitory activity....
Abstract CCL14 is a member of CC chemokines and its role in hepatocellular carcinoma (HCC) still unknown. In this study, expression were analyzed by tissue microarray (TMA) including 171 paired tumor peritumor tissues patients from Zhongshan Hospital Fudan University. We found for the first time that was downregulated HCC compared with ( P = 0.01). Meanwhile, low associated poor prognosis 0.035). also displayed predictive value high differentiation 0.026), liver cirrhosis 0.003), no capsule...
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy with limited treatment options and a dismal prognosis. The tumor immune microenvironment (TIME) crucial for iCCA progression, yet its comprehensive characterization remains incomplete. This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze cell populations in fresh samples adjacent peritumor tissues. Notably, NK percentages significantly decreased lesions compared Conversely, enrichment...
CCR7 is a G protein-coupled chemokine receptor. In this study, we used immunohistochemistry with tissue microarrays to measure expression in tumor specimens from 122 patients gastric cancer. We show that associated lymph node metastasis (P = 0.022) and overall survival (OS; P 0.025), an independent factor poorer 0.032). The mechanism was predicted based on bioinformatic analysis verified cancer cell lines primary samples. data contributes TGF-β1-induced epithelial-mesenchymal transition...
p53 is a potent transcription factor that crucial in regulating cellular responses to stress. Mutations the TP53 gene are found >50% of human cancers, predominantly occurring DNA-binding domain (amino acids 94–292). The Y220C mutation accounts for 1.8% all mutations and produces thermally unstable protein. Rezatapopt (also known as PC14586) first small-molecule reactivator being evaluated clinical trials. was specifically designed tightly bind pocket created by mutation. By stabilization...
Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development metabolomic technologies has enabled the capture metabolic changes related to progression cirrhosis. This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models explore role cirrhosis risk stratification CLD. Metabolomic were integrated aspartate aminotransferase...
Abstract Frequency combs show various applications in molecular fingerprinting, imaging, communications, and so on. In the terahertz frequency range, semiconductor-based quantum cascade lasers (QCLs) are ideal platforms for realizing comb operation. Although self-started operation can be obtained free-running QCLs due to four-wave mixing locking effects, resonant/off-resonant microwave injection, phase locking, femtosecond laser based techniques have been widely used broaden stabilize QCL...
Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an essential role in modulating inflammatory responses and extracellular matrix remodeling.However, little is known regarding the of TSG-6 human cancers.Here, we investigated mechanism action colorectal cancer (CRC) metastasis.We found that was highly expressed tumor tissues associated with poor prognosis metastasis CRC.Mechanistically, overexpression CRC cells resulted ERK activation epithelial-mesenchymal...
Abstract Background The opposite effects of chemotherapy, which enhance the malignancy treated cancers such as hepatocellular carcinoma (HCC), are not well understood. We investigated this phenomenon and corresponding mechanisms to develop a novel approach for improving chemotherapy efficacy in HCC. Methods Human cell lines HepG2 (with low metastatic potential) MHCC97L moderate were used vitro study. An orthotopic nude mouse model human HCC was developed using cells. then assessed potential...
Background: Metastasis is a major reason for poor prognosis in patients with cancer, including hepatocellular carcinoma (HCC). A salient feature the ability of cancer cells to colonize different organs. Long non-coding RNAs (lncRNAs) play important roles numerous cellular processes, metastasis. Materials and Methods: In this study, lncRNA expression profiles two HCC cell lines, one high potential metastasis lung (HCCLM3) other lymph nodes (HCCLYM-H2) were assessed using Arraystar Human...
Angiogenesis is a crucial process in tumorigenesis and development. The role of exosomes derived from hepatocellular carcinoma (HCC) cells angiogenesis has not been clearly elucidated.Exosomes were isolated HCC cell lines (HCCLM3, MHCC97L, PLC/RFP/5) by ultracentrifugation identified nano transmission electron microscopy (TEM), NanoSight analysis western blotting, respectively. In vitro vivo analyses showed that highly metastatic enhanced the migration, invasion tube formation human...
Abstract Mutations in the TP53 gene are most frequent somatic alterations human cancer; approximately 50% of all cancers possess mutations TP53. Missense which result a non-functional protein frequently identified, these occur across gene, however hotspot localized within DNA binding domain protein. Y220C is one such mutation, prevalent ~1.8% mutant tumors. PC14586 was structurally designed to bind tightly crevice (KD~2.5 nM). It first orally bioavailable small molecule and selective...