A5037657103- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Covalent Organic Framework Applications
- Pancreatic and Hepatic Oncology Research
- Electrocatalysts for Energy Conversion
- Algal biology and biofuel production
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- PI3K/AKT/mTOR signaling in cancer
- Nanoparticles: synthesis and applications
- Catalytic Processes in Materials Science
- Conducting polymers and applications
- Radiomics and Machine Learning in Medical Imaging
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
- Silicon Effects in Agriculture
- Noise Effects and Management
- Ferroptosis and cancer prognosis
- Carbon and Quantum Dots Applications
Unimed Medical Institute
2018-2024
Xiamen University
2023-2024
First Affiliated Hospital of Xiamen University
2024
University of Shanghai for Science and Technology
2024
Chongqing Normal University
2022-2023
Fudan University
2023
State Key Laboratory of Pollution Control and Resource Reuse
2020-2022
Nanjing University
2020-2022
Zhejiang University of Technology
2022
Zhejiang University
2021
Abstract Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tissues and matched blood specimens over 10,000 in China by using 450-gene assay, developed implemented under international clinical regulations. We comparison somatically altered genes, distribution mutational burden (TMB), gene fusion patterns,...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and leading cause cancer-related death. Over past few decades, genomic alterations driver genes have been identified in NSCLC, molecular testing targeted therapies become standard care for patients. Here we studied unique profile Chinese patients with NSCLC by next-generation sequencing (NGS) assay. Materials Methods A total 1,200 were enrolled this study. The median age was 60 years (range:...
Incorporation of next-generation sequencing (NGS) technology into clinical utility in targeted and immunotherapies requires stringent validation, including the assessment tumor mutational burden (TMB) microsatellite instability (MSI) status by NGS as important biomarkers for response to immune checkpoint inhibitors.We designed an assay, Cancer Sequencing YS panel (CSYS), applied algorithms detect five classes genomic alterations two features TMB MSI.By CSYS exhibited high sensitivity...
Abstract Background Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role the features and immunotherapy cholangiocarcinoma (CCA) unclear. This study aimed to systematically investigate characterization efficacy of MSI-H patients with CCA. Methods We enrolled 887 CCA this study. Tumor samples were collected for next-generation sequencing. Differences alterations between microsatellite stability (MSS) groups analyzed. also investigated survival...
Certain engineered nanoparticles (NPs) have unique properties that exhibited significant potential for promoting photosynthesis and enhancing crop productivity. Understanding the fundamental interactions between NPs plants is crucial sustainable development of nanoenabled agriculture. Leaf mesophyll protoplasts, which maintain similar physiological response cellular activity as intact plants, were selected a model system to study impact on photosynthesis. The protoplasts isolated from...
Fully understanding the environmental implications of engineered nanomaterials is crucial for their safe and sustainable use. Cyanobacteria, as pioneers planet earth, play important roles in global carbon nitrogen cycling. Here, we evaluated biological effects molybdenum disulfide (MoS2) nanosheets on a N2-fixation cyanobacteria (Nostoc sphaeroides) by monitoring growth metabolome changes. MoS2 did not exert overt toxicity to Nostoc at tested doses (0.1 1 mg/L). On contrary, intrinsic...
The rapid development of computational pathology has brought new opportunities for prognosis prediction using histopathological images. However, the existing deep learning frameworks lack exploration relationship between images and other prognostic information, resulting in poor interpretability. Tumor mutation burden (TMB) is a promising biomarker predicting survival outcomes cancer patients, but its measurement costly. Its heterogeneity may be reflected Here, we report two-step framework...
Abstract Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers, can be divided into head and body/tail cancers anatomically. We previously reported a prognostic relevance tumour location in resectable PDAC. This study aimed to further explore mechanism underlying molecular diversity between PDACs. detected genomes 154 (surgery) non‐resectable (biopsy) PDACs using next‐generation sequencing panel. Wilcoxon's rank test or Fisher's exact was used for evaluating...
The wide application of nanotechnology has led to the inevitable release and transport metal-based nanoparticles (MNPs) into environment. However, very few studies have examined occurrence MNPs in indoor dust. Here, we report 10 distinct types dust, confirming its carrier role for MNPs. In particular, up ∼4000 μg MNPs/g including Fe-based (∼200 nm, equivalent spherical diameter), were found dust samples collected from both residential public areas. Though exhibited a magnetic response,...
Gastric cancer (GC) has a high incidence and mortality rate, especially in East Asians, about 90% of GCs are adenocarcinomas. Histological etiological heterogeneity ethnic diversity make molecular subtyping GC complicated, thus making it difficult to determine division systems standard treatment modalities. Limited cohorts from South Korea, Singapore, Australia, Japan have been studied; however, the mutational landscape gastric adenocarcinomas Chinese patients is still unknown.We performed...
Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren's disease (pSjD). Here we aimed to identify proteins as potential biomarkers and establish non-invasive prediction model pSjD. Liquid chromatography-tandem mass spectrometry was conducted on whole saliva samples from patients with pSjD non-Sjögren control subjects (non-pSjD). Proteins involved in immune processes were upregulated group, such complement C3 (C3), factor B (CFB),...
Hormone-like signaling peptides play essential roles in plant growth and development; however, few regulating root development have been identified rice (Oryza sativa). Here, we combined liquid chromatography-tandem mass spectrometry (LC-MS/MS) with whole-genome silico screening for root-secreted rice. We the five-amino-acid PEPTIDE 1 (PEP1) encoded by OsPEP1 (LOC_Os11g09560). was expressed highly tissues, especially cap cells epidermal maturation zone. Exogenous application of PEP1...
RING finger protein 13 (RNF13) is a novel E3 ubiquitin ligase whose expression associated with cancer development. However, its specific role in progression and metastasis remains unclear. Here, B16F10/LLC experimental pulmonary metastatic model was developed to examine the formation of foci lung. A greater number tumor colonies were observed lungs RNF13-knockout (KO) mice than their wild-type (WT) littermates, whereas no significant differences size between two groups. In short-term...
NiO/MoO<sub>3</sub> exhibits high catalytic activity, and the carbon deposition can be used as nanopesticide.
e16253 Background: Hepatocellular carcinoma (HCC) is a highly lethal and aggressive malignant tumor characterized by high rates of recurrence metastasis, low survival outcomes. The current treatments available for HCC have shown limited success, the prevalence genomic characterization their association with in patients are largely unknown. Methods: investigation enrolled 1,221 Chinese individuals diagnosed primary HCC. This study collected samples including paired tumor-free tissues clinical...
Hydrogen peroxide (H2O2) is a crucial energy carrier with growing significance in sustainable systems. Covalent organic frameworks (COFs) have recently emerged as promising materials for efficient H2O2 photosynthesis, while transition-metal complexes are recognized their efficacy molecular photocatalysts production. This study introduces novel π–π interaction strategy to immobilize ruthenium into COFs, using DaTp COF model system. approach significantly enhances the photocatalytic activity...
Abstract Background: Protein arginine methyltransferase 5 (PRMT5) is an enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine (SAM) to residues on histones and other proteins. The dysregulation this methylation critical in development certain cancers. MTAPhd can cause anti-tumor effect PRMT5 inhibitor via a synthetic lethality mechanism. Methods: 9,202 cases were collected subjected NGS for genomic alteration detection. testing was carried out by College American...
Heterogenization of molecular catalysts effectively resolves the separation issues homogeneous and expands their application scenarios. In recent years, more studies have been using non-covalent interactions to achieve heterogenization catalysts. Herein, electrostatic attraction was used immobilize catalysts, Ru-bda small in COF materials, where charged were immobilized oppositely with a high [Ru] loading content ~0.2 mmol g
The combination of low and high order features in the recommendation system is crucial to predicted click through rate. This paper designs an Attention Deep Cross Recognition Machine (ADCAFM). Traditional models only use attention factor decomposers deep cross networks extract features, but diversity mining user interests weak. Therefore, this extracts feature depth different subspaces by integrating multi head mechanism solve problem interest network mining; Finally, combined are...