A5103069871- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Urinary Bladder and Prostate Research
First Hospital of Jiaxing
2013-2025
Jiaxing University
2019-2025
China Pharmaceutical University
2017-2025
South China Agricultural University
2020-2024
Shaoxing University
2023
Zhejiang Medicine (China)
2023
Fujian Medical University
2005-2023
State Key Laboratory of Natural Medicine
2017-2022
Nanjing Drum Tower Hospital
2022
Songjiang District Central Hospital
2022
Mutations in the copper/zinc superoxide dismutase (mSOD1) gene are associated with a familial form of amyotrophic lateral sclerosis (ALS), and their expression transgenic mice produces an ALS-like syndrome. Recent observations suggest role for inflammatory-related events progression propagation neurodegenerative process ALS. Consistent this view, present study demonstrates that, during course disease, cyclooxygenase type 2 (Cox-2), key enzyme synthesis prostanoids, which potent mediators...
Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing cytosolic DNA to initiate dsDNA-driven In vitro vivo anti-psoriasis effects STING antagonist H-151 were explored.We analysed the gene expression profile related downstream targets samples healthy people psoriasis patients from GEO database. Cellular inhibitory activity on pathway was confirmed via qPCR western...
Molecular mechanisms of apoptosis may participate in motor neuron degeneration produced by mutant copper/zinc superoxide dismutase (mSOD1), the only proven cause amyotrophic lateral sclerosis (ALS). Consistent with this, herein we show that spinal cord transgenic mSOD1 mice is site sequential activation caspase-1 and caspase-3. Activated caspase-3 its β-actin cleavage fragments are found apoptotic neurons anterior horn affected mice; although such few, their scarcity should not undermine...
Antimicrobial resistance poses a significant global challenge, demanding innovative approaches, such as the CRISPR-Cas-mediated plasmid or gene-curing system, to effectively combat this urgent crisis. To enable successful curing of antimicrobial genes plasmids through CRISPR-Cas technology, development an efficient broad-host-range delivery system is paramount. In study, we have successfully designed and constructed novel functional gene plasmid, pQ-mini, utilizing backbone Inc.Q plasmid....
Essential myoclonus-dystonia is a neurological condition characterized by myoclonic and dystonic muscle contractions the absence of other signs or laboratory abnormalities; it often responsive to alcohol. The disorder may be familial with apparent autosomal dominant inheritance. We report large kindred essential map locus for 28-cM region chromosome 7q21-q31.
B7 family members and their receptors play key roles in regulating T cell responses, constitute very attractive targets for developing immunotherapeutic drugs. V-Set Immunoglobulin domain containing 3 (VSIG3), a ligand the novel immune checkpoint V-domain immunoglobulin suppressor of activation (VISTA), can significantly inhibit functions. Inhibitors targeting VISTA/VSIG3 pathway are great significance tumor immunology. Here, we show crystal structure extracellular (ECD) human VSIG3 protein...
Abstract V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation mice. Treatment with VISTA agonistic antibody could significantly improve asthma symptoms. Thus, for treatment, targeting may be compelling approach. In this study, we examined the functional mechanism and screened FDA-approved drugs agonists. By using mass cytometry (CyTOF), found that deficiency primarily...
Abstract The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important role in the regulation of vascular maturation and maintenance vessel integrity. In this study, we have investigated effect systemic Tie2 activation or inhibition on tumor growth metastasis. We found that treatment with Ang1 delivered via adenoviral vector promoted s.c. implanted metastasis lungs. did not significantly increase density tumors but induced enlargement blood vessels both normal tissues, which...
Vascular tone, an important determinant of systemic vascular resistance and thus blood pressure, is affected by smooth muscle (VSM) contraction. Key signaling pathways for VSM contraction converge on phosphorylation the regulatory light chain (RLC) myosin. This mediated Ca(2+)/calmodulin-dependent myosin kinase (MLCK) but Ca(2+)-independent kinases may also contribute, particularly in sustained contractions. Signaling through MLCK has been indirectly implicated maintenance basal whereas RhoA...
Significance The polar overdominance inheritance of callipyge sheep is an unusual mode non-Mendelian inheritance. We established a mouse line with deletion the microRNA (miR) 379/miR-544 cluster and assessed role this in Our results showed that maternally expressed miR-379/miR-544 might regulate skeletal muscle growth through imprinted Delta-like 1 homolog ( Dlk1 ) gene. This report revealed molecular mechanism
Reactive carbonyl species (RCS), such as methylglyoxal (MG) and glyoxal (GO), are synthesized toxic metabolites in living systems. Mechanisms of RCS detoxification include the glutathione (GSH)-dependent system consisting glyoxalase I (GLO1) II (GLO2), GSH-independent involving III (GLO3). Hsp31 DJ-1 proteins weakly homologous to each other belong two different subfamilies DJ-1/Hsp31/PfpI superfamily. Recently, Escherichia coli protein from Arabidopsis thaliana metazoans have been...
Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss this leads to disorders faecal incontinence. However, molecular mechanisms underlying remain unknown. Here, we show that deletion myosin light-chain kinases (MLCK) in smooth cells from internal anal sphincter (IAS-SMCs) abolishes tone, impairing defecation. Pharmacological regulation ryanodine receptors (RyRs), L-type voltage-dependent Ca(2+) channels (VDCCs) or...
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying agonistic relaxation of airway smooth muscle (ASM) not well defined. By exploring ASM bitter substances, we observed that pretreatment with substances nearly abolished methacholine (MCh)-induced increase in cell (ASMC) calcium concentration, thereby suppressing calcium-induced contraction...
USP7 emerges as a potential therapeutic target for cancers, it plays an important role in the development of tumorigenesis by stabilizing multiple cancer-relevant proteins. Nevertheless, discovery drug-like inhibitors remains challenging. Herein, we report series N-benzylpiperidinol derivatives potent and selective (e.g., X20 X26: IC50 = 7.6 8.2 nM), whose binding modes were revealed crystallographic studies to be distinct from known N-acylpiperidinol inhibitors. Among them, X36 with good...