A5101973852- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Viral-associated cancers and disorders
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Copper-based nanomaterials and applications
- Genomics and Rare Diseases
- Macrophage Migration Inhibitory Factor
- Fibroblast Growth Factor Research
- Magnesium Alloys: Properties and Applications
- Cancer-related gene regulation
Sun Yat-sen Memorial Hospital
2016-2025
Sun Yat-sen University
2016-2025
Southern Medical University
2016
Nanfang Hospital
2016
Abstract Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tissues and matched blood specimens over 10,000 in China by using 450-gene assay, developed implemented under international clinical regulations. We comparison somatically altered genes, distribution mutational burden (TMB), gene fusion patterns,...
Abstract Background Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis human cancers. However, role circRNAs esophageal squamous cell carcinoma (ESCC) remains unclear. In this study, we aimed to identify that regulate ESCC progression and explored their regulatory mechanisms clinical significance ESCC. Methods Differentially expressed between paired adjacent normal tissues were identified using microarrays. The effects specific...
Early diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding (lncRNA) expressed from HOXC locus, has been recently revealed as oncogenic regulator in ESCC. This study aimed investigate whether serum HOTAIR involved ESCC.In this study, we detected expression 50 patients with ESCC (including 42 tumor resection and 8 without surgery) 20 healthy volunteers role using quantitative real-time...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and leading cause cancer-related death. Over past few decades, genomic alterations driver genes have been identified in NSCLC, molecular testing targeted therapies become standard care for patients. Here we studied unique profile Chinese patients with NSCLC by next-generation sequencing (NGS) assay. Materials Methods A total 1,200 were enrolled this study. The median age was 60 years (range:...
Reactive oxygen species (ROS)-induced cytotoxicity is an important mechanism by which cisplatin kills tumor cells. Glutathione peroxidase family (GPXs) member of antioxidant system metabolizes intracellular ROS and maintains homeostasis Altered expressions GPXs enzymes, especially GPX1, have been described in a variety human cancers. However, their functional roles cisplatin-based chemoresistance malignancies including non-small cell lung cancer never explored.A panel NSCLC lines were...
Pulmonary hypertension (PH) is associated with increased expression of VEGF-A (vascular endothelial growth factor A) and its receptor, VEGFR2 2), but whether how activation signal participates in the pathogenesis PH unclear.VEGF-A/VEGFR2 Y949-dependent vascular leak were investigated lung samples from patients mice exposed to hypoxia. To study their mechanistic roles hypoxic PH, we examined right ventricle systolic pressure, ventricular hypertrophy, pulmonary vasculopathy mutant carrying...
Increasing studies have indicated that circular RNAs (circRNAs) are important in cancer progression.However, few circRNAs associated with epithelial-mesenchymal transition (EMT) been elucidated esophageal squamous cell carcinoma (ESCC).In this study, we aimed to identify whether hsa_circ_0006948 promotes ESCC EMT and explore its biological mechanisms.We first screened circRNA expression profiles using a microarray, found the of novel circRNA, hsa_circ_0006948, is increased 153 tissues lines...
Background The purpose of this study was to investigate the safety and efficacy left thoracic approach (LTA) right (RTA) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant immunochemotherapy (NICT).
Abstract Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of non-small-cell lung cancer. Duo to the current lack precise targeted therapies, there an urgent need identify novel therapeutic targets. In this study, we perform single-nucleus transcriptome analysis on PPLELC samples reveal molecular tumor heterogeneity and characterize functional states immune cells within microenvironment. We critical malignant subpopulation characterized by elevated expression AKT3...
Abstract Objectives Worldwide, lung cancer accounts for the majority of cancer‐related deaths. Aberrant expression mi RNA s has increasingly been reported to be associated with tumour progression. This study aimed explore role miR‐301b in regulating apoptosis cancer. Materials and methods Expression was assessed by real‐time PCR cell lines, human patient tissues cells treated under hypoxia DMOG . Scramble si , inhibitor mimics were transfected into determine their effects on apoptosis....
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors around world. Numerous studies have revealed function long noncoding RNAs (lncRNAs) in cancers, including ESCC. In this study, lncRNA small nucleolar RNA host gene 12 (SNHG12), mainly distributed ESCC cytoplasm, was overexpressed specimens and CD133 + cells. ‐ cells, SNHG12 overexpression promoted proliferation, migration, epithelial–mesenchymal transition (EMT), stemness silencing led to opposite results....
The biology of esophageal squamous cell carcinoma (ESCC) remains poorly understood. Long noncoding RNAs (lncRNAs) are found to be dysregulated in a variety cancers, including ESCC. SPRY4-IT1 has been recently revealed as oncogenic regulator or tumor suppressors different cancers; however, whether is involved ESCC To investigate the role ESCC, we evaluated expression levels series patients and panel line using qRT-PCR. CCK8 colony formation assay were performed assess effect SPRY4-IT1siRNA on...
Abstract Esophageal squamous carcinoma (ESCC) is a common malignant cancer. Although the non-coding roles of circRNAs in pathogenesis human tumors have been well studied, whether participate progression ESCC by encoding novel proteins remains unclear. In this study, we identified an overexpression circRNA with protein-coding ability tissues, called circUBE4B, whose expression level correlated tumor size and differentiation patients. Moreover, higher circUBE4B patients worse prognosis....
Background: In microenvironment of malignant tumors, Hypoxia-Inducible Factors (HIF), most importantly HIF-1α, play an important role in regulation adaptive biological response to hypoxia, promoting angiogenesis and metastasis. However, the underlying mechanism that HIF-1α regulates metastasis needs be further clarified. Methods: The expressions SP1 were detected 182 samples esophageal squamous cell carcinoma (ESCC) adjacent normal tissues by immunohistochemistry (IHC), correlation between...
Background. Lipid metabolism reprogramming played an important role in cancer occurrence, development, and immune regulation. The aim of this study was to identify validate lipid metabolism-related genes (LMRGs) associated with the phenotype, prognosis, immunological characteristics lung squamous cell carcinoma (LUSC). Methods. In TCGA cohort, bioinformatics survival analysis were used differentially expressed (DEGs) prognosis LUSC. PTGIS/HRASLS knockdown overexpression effects on LUSC...
Lung adenocarcinoma (LUAD) is the most predominant subtype of non-small cell lung cancer (NSCLC) that experiencing fastest growth rate in incidence. Chemoresistance and presence stem cells are considered to be main obstacles preventing successful treatment patients with NSCLC, molecular mechanism which remains poorly understood. The present study aimed investigate effects microRNA (miR)-140-3p on cisplatin sensitivity cell-like properties LUAD cells. Analysis publicly available data...
Abstract Background The aim of this study was to evaluate the safety, efficacy, and oncologic outcomes neoadjuvant immunotherapy combined with chemotherapy (NICT) group surgery alone in treatment patients locally advanced esophageal squamous cell carcinoma (ESCC). Methods A series 232 consecutive who underwent or without NICT from June 2019 August 2022 were evaluated. We performed propensity score matching between groups on basis estimated scores for each patient. Results After matching,...