A5041886634- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Medicinal Plants and Bioactive Compounds
- Cancer Genomics and Diagnostics
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
Sun Yat-sen Memorial Hospital
2020-2025
Sun Yat-sen University
2020-2025
Abstract Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of non-small-cell lung cancer. Duo to the current lack precise targeted therapies, there an urgent need identify novel therapeutic targets. In this study, we perform single-nucleus transcriptome analysis on PPLELC samples reveal molecular tumor heterogeneity and characterize functional states immune cells within microenvironment. We critical malignant subpopulation characterized by elevated expression AKT3...
Background: Gastric cancer was still one of the commonly diagnosed types and third-most common cause cancer-related death in world. Gentiopicroside, which is extracted from Gentianella acuta , used both traditional treatment modern clinical care; therefore, its anticancer effects have been attracted more attention. However, systematic analysis action mechanism Gentiopicroside on gastric (GC) has not yet carried out. Aim: A network pharmacology-based strategy combined with molecular docking...
Abstract Esophageal squamous carcinoma (ESCC) is a common malignant cancer. Although the non-coding roles of circRNAs in pathogenesis human tumors have been well studied, whether participate progression ESCC by encoding novel proteins remains unclear. In this study, we identified an overexpression circRNA with protein-coding ability tissues, called circUBE4B, whose expression level correlated tumor size and differentiation patients. Moreover, higher circUBE4B patients worse prognosis....
Background. Lipid metabolism reprogramming played an important role in cancer occurrence, development, and immune regulation. The aim of this study was to identify validate lipid metabolism-related genes (LMRGs) associated with the phenotype, prognosis, immunological characteristics lung squamous cell carcinoma (LUSC). Methods. In TCGA cohort, bioinformatics survival analysis were used differentially expressed (DEGs) prognosis LUSC. PTGIS/HRASLS knockdown overexpression effects on LUSC...
e16108 Background: Esophageal squamous cell carcinoma (ESCC) remains an aggressive malignancy and most patients are diagnosed at advantage stage with limited treatments. Large amount of evidence has demonstrated that immune biomarkers such as PD-l/PD-L1 tumor mutational burden (TMB) associated clinical outcomes disease prognosis. Methods: A total 475 ECSS enrolled in this study. Deep sequencing 450 cancer genes performed on formalin-fixed paraffin-embedded tissues matched blood. Results:...
e16030 Background: Blockade of programmed cell death 1 (PD-1) could induce tumor regression in patients with advanced esophageal squamous carcinoma (ESCC), although little is known about the biomarker to guide immunochemotherapy. In this study, we sought evaluate efficacy and discover biomarkers establish an artificial intelligence (AI) model predict combination sintilimab chemotherapy treatment ESCC. Methods: Fifty-nine (59) enrolled our study received follow-up data were available....
ObjectiveAberrant MET activation, which promotes cell proliferation and tumor metastasis, occurs in many types of cancer results from multiple mechanisms. A novel duplication mutation was found a non-small lung (NSCLC) patient. The clinical response to crizotinib investigated the functional relevance characterized cellular models.Materials MethodsNext-generation sequencing (NGS) performed on tissue circulating DNA (ctDNA) patient with advanced NSCLC. In vitro studies including western blot,...
e20506 Background: Differentiation of multiple primary lung cancer (MPLC) from intrapulmonary metastasis (IPM) is critical to determine clinical stage. Although clinicopathological features could provide certain evidences, it’s still challenging identify the tumor malignancy accurately. In General, standard histopathologic approach adequate in most cases, but has notable limitations recognition IPMs. Herein, we propose an integrated molecular algorithm facilitate MPLCs and IPMs diagnosis...