A5100364222- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Gut microbiota and health
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
Shanghai Pulmonary Hospital
2016-2025
Tongji University
2016-2025
Wenzhou Medical University
2020-2025
Shihezi University
2023-2025
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Shanghai University of Traditional Chinese Medicine
2017-2024
First Affiliated Hospital of Shihezi University Medical College
2022-2024
Northwestern University
2022-2024
Neurological Surgery
2022-2024
Northwestern Medicine
2024
Abstract Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows remarkable efficacy in a variety of cancer types. However, only minority patients respond to treatment due the stochastic heterogeneity tumor microenvironment (TME). Recent advances single-cell RNA-seq technologies enabled comprehensive characterization immune system tumors but posed computational challenges on integrating and utilizing massive published datasets inform immunotherapy. Here, we present...
Alterations of gut microbiota have been implicated in multiple diseases including cancer. However, the spectrum lung cancer remains largely unknown. Here we profiled composition a discovery cohort containing 42 early-stage patients and 65 healthy individuals through 16S ribosomal RNA (rRNA) gene sequencing analysis. We found that displayed significant shift contrast to populations. To identify optimal signature for noninvasive diagnosis purpose, took advantage Support-Vector Machine (SVM)...
Abstract The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for Kras LSL−G12D/+ Tp53 fl/fl (KP) and Lkb1 (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into TME promote T expansion. exhibits high expression in tissues is positively correlated with infiltration cDC1 overall survival patients. deficiency impairs subsequent expansion CD8 +...
Abstract Background Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced marked decrease in dietary fiber intake, but potential mechanism linking low intake cognitive impairment poorly understood. Emerging research reported that diversity gut microbiota Western populations significantly reduced. However, it unknown whether fiber-deficient diet (which alters microbiota)...
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition chemotherapy remains unknown. Objective To determine whether toripalimab in platinum-based will improve event-free survival major pathological response stage II or III resectable NSCLC compared alone. Design, Setting, Participants This randomized trial enrolled (without EGFR ALK...
Immunotherapy has revolutionized cancer treatment, but most patients are refractory to immunotherapy or acquire resistance, with the underlying mechanisms remaining be explored.We characterized transcriptomes of ~92,000 single cells from 3 pre-treatment and 12 post-treatment non-small cell lung (NSCLC) who received neoadjuvant PD-1 blockade combined chemotherapy. The samples were categorized into two groups based on pathologic response: major response (MPR; n = 4) non-MPR (NMPR; 8).Distinct...
425126 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US FDA to treat early-stage NSCLC. However, the optimal adjuvant treatment, including duration of are unknown. We present interim results a randomized, double-blind, placebo-controlled, phase III trial evaluate efficacy safety perioperative toripalimab plus chemotherapy followed maintenance vs in resectable stage Methods: Patients with II/III NSCLC, without EGFR/ALK alterations for non-squamous were randomly...
Abstract The proper regulation of transcription is essential for maintaining genome integrity and executing other downstream cellular functions 1,2 . Here we identify a stable association between the genome-stability regulator sensor single-stranded DNA (SOSS) 3 Integrator-PP2A (INTAC) 4–6 Through SSB1-mediated recognition DNA, SOSS–INTAC stimulates promoter-proximal termination attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced instability....
Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis altered in high-fat diet (HFD)-induced impairment closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) an derivative has recently attracted extensive interest due to its anti-inflammatory effect. study investigated whether intraperitoneal administration of DI improves prevents deficits HF diet-fed mice.DI effectively attenuated...
Tertiary lymphoid structures (TLSs) have been proposed to assess the prognosis of patients with cancer. Here, we investigated prognostic value and relevant mechanisms TLSs in colorectal cancer liver metastases (CRCLM).603 CRCLM treated by surgical resection from three centers were included. The categorized according their anatomic subregions quantified, a TLS scoring system was established for intratumor region (T score) peritumor (P score). Differences relapse-free survival (RFS) overall...
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining regimen with anti-angiogenesis may improve efficacy. ETER701 was a multicenter, double-blind, randomized, placebo-controlled phase 3 trial that investigated efficacy and safety of benmelstobart (a novel programmed death-ligand 1 (PD-L1) inhibitor) anlotinib multi-target anti-angiogenic small molecule) chemotherapy in treatment-naive ES-SCLC. The assessed two primary endpoints:...
Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, greatly limited the hypoxia microenvironment (TME) and antioxidant defense. Amplification of oxidative stress has been successfully employed for therapy, but interactions between cells other factors TME usually lead to inadequate treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on remodeling cancer-associated fibroblasts...
Abstract In response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies fight against microbes including phagocytosis, degranulation, neutrophil extracellular traps (NETs). NETs a meshwork of chromatin fibers mixed with granule-derived antimicrobial peptides enzymes, which trap kill bacteria extracellularly. this study, by using mouse sepsis model, we identified novel mechanism induce macrophage (Mϕ) pyroptosis,...
Our pilot study using miRNA arrays found that miRNA-29c (miR-29c) is differentially expressed in the paired low-metastatic lung cancer cell line 95C compared to high-metastatic 95D. Bioinformatics analysis shows integrin β1 and matrix metalloproteinase 2 (MMP2) could be important target genes of miR-29c. Therefore, we hypothesized miR-29c suppresses adhesion extracellular (ECM) metastasis by targeting MMP2. The gain-of-function studies raised expression 95D cells its mimics showed reductions...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and leading cause cancer-related death. Over past few decades, genomic alterations driver genes have been identified in NSCLC, molecular testing targeted therapies become standard care for patients. Here we studied unique profile Chinese patients with NSCLC by next-generation sequencing (NGS) assay. Materials Methods A total 1,200 were enrolled this study. The median age was 60 years (range:...
Abstract Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolomics on resected lesions plasma obtained invasive LUAD its precursors, decipher the trajectories atypical adenomatous hyperplasia (AAH) in situ (AIS), minimally (MIA) (IAC), revealing that perturbed pathways emerge early premalignant lesions....
Machine learning is an important artificial intelligence technique that widely applied in cancer diagnosis and detection. More recently, with the rise of personalised precision medicine, there a growing trend towards machine applications for prognosis prediction. However, to date, building reliable prediction models outcomes everyday clinical practice still hurdle. In this work, we integrate genomic, demographic data lung adenocarcinoma (LUAD) squamous cell carcinoma (LUSC) patients from The...