A5100376910- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Genomics and Rare Diseases
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Genomic variations and chromosomal abnormalities
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Virus-based gene therapy research
- Tracheal and airway disorders
- Gastroesophageal reflux and treatments
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
Wuhan Sports University
2022-2025
Jining Medical University
2023-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Sichuan Normal University
2023-2024
Anhui University
2022-2024
Ministry of Education of the People's Republic of China
2024
Qingdao University
2020-2024
National Taipei University of Business
2023
Abstract Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tissues and matched blood specimens over 10,000 in China by using 450-gene assay, developed implemented under international clinical regulations. We comparison somatically altered genes, distribution mutational burden (TMB), gene fusion patterns,...
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strategy. Pyroptosis is a gasdermin-driven lytic programmed death triggered by inflammatory caspases when initiated canonical or noncanonical pathways has been recently seen potential therapeutic target in treatment. However, overcoming chemoresistance...
Background It is currently unclear whether the expression of HOX transcript antisense RNA (HOTAIR) correlates with progression esophageal cancer. The aim this study was to examine HOTAIR in patients squamous cell cancer (ESCC) and explore its clinical significance. Methods Differences were examined via situ hybridization (ISH) quantitative reverse transcriptase PCR (qRT-PCR). prognostic significance evaluated using Kaplan–Meier Cox regression analyses. Proliferation, colony formation...
Abstract Background Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis human cancers. However, role circRNAs esophageal squamous cell carcinoma (ESCC) remains unclear. In this study, we aimed to identify that regulate ESCC progression and explored their regulatory mechanisms clinical significance ESCC. Methods Differentially expressed between paired adjacent normal tissues were identified using microarrays. The effects specific...
MicroRNAs are involved in regulating the biology of cancer cells, but their involvement chemoresistance is not fully understood. We found that miR-663 was up-regulated our induced multidrug-resistant MDA-MB-231/ADM cell line and this up-regulation closely related to chemosensitivity. In present study, we aimed clarify role breast cancer. MicroRNA microarray quantitative RT-PCR assays were used identify differentially expressed microRNAs. Cell apoptosis evaluated by annexin V/propidium iodide...
Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR and are generally refractory to the 1st 2nd generation tyrosine kinase inhibitors (TKIs). Development effective therapies for patients with EGFRex20ins mutant non-small-cell lung carcinoma (NSCLC) represents a great unmet need. Preclinical models have shown that osimertinib is active in NSCLC harboring EGFRex20ins, while antitumor activity remains be evaluated mutations.Tumor...
Early diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding (lncRNA) expressed from HOXC locus, has been recently revealed as oncogenic regulator in ESCC. This study aimed investigate whether serum HOTAIR involved ESCC.In this study, we detected expression 50 patients with ESCC (including 42 tumor resection and 8 without surgery) 20 healthy volunteers role using quantitative real-time...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and leading cause cancer-related death. Over past few decades, genomic alterations driver genes have been identified in NSCLC, molecular testing targeted therapies become standard care for patients. Here we studied unique profile Chinese patients with NSCLC by next-generation sequencing (NGS) assay. Materials Methods A total 1,200 were enrolled this study. The median age was 60 years (range:...
Abstract Background Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate association between cytokine profiles lung injury in COVID-19 pneumonia. Methods This retrospective conducted patients. Demographic characteristics, symptoms, signs, underlying diseases, laboratory data were collected. patients divided into with pneumonia without CT severity score...
Pulmonary hypertension (PH) is associated with increased expression of VEGF-A (vascular endothelial growth factor A) and its receptor, VEGFR2 2), but whether how activation signal participates in the pathogenesis PH unclear.VEGF-A/VEGFR2 Y949-dependent vascular leak were investigated lung samples from patients mice exposed to hypoxia. To study their mechanistic roles hypoxic PH, we examined right ventricle systolic pressure, ventricular hypertrophy, pulmonary vasculopathy mutant carrying...
Increasing studies have indicated that circular RNAs (circRNAs) are important in cancer progression.However, few circRNAs associated with epithelial-mesenchymal transition (EMT) been elucidated esophageal squamous cell carcinoma (ESCC).In this study, we aimed to identify whether hsa_circ_0006948 promotes ESCC EMT and explore its biological mechanisms.We first screened circRNA expression profiles using a microarray, found the of novel circRNA, hsa_circ_0006948, is increased 153 tissues lines...
Abstract The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery new medicines. We have developed novel method that rapidly screens multiple proteins parallel using DNA-encoded library technology (ELT). Initial efforts were focused on efficient antibacterial leads against 119 from Acinetobacter baumannii Staphylococcus aureus . success this effort led to hypothesis relative number ELT binders alone could be used assess...
Abstract Motivation Detecting driver genes from gene mutation data is a fundamental task for tumorigenesis research. Due to the fact that cancer heterogeneous disease with various subgroups, subgroup-specific are key factors in development of precision medicine cancer. However, existing detection methods not designed identify subgroup specificities their detected genes, and therefore cannot indicate which group patients associated difficult provide specifically clinical guidance individual...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays key role in the development of ESCC. CircRNAs have been reported to be involved regulation pathway, but underlying mechanisms are unclear. Therefore, this study aimed identify protein-coding circRNAs investigate their functions Methods Differential expression between ESCC tissues adjacent normal was identified...
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder on a global scale. Atherosclerosis (AS), leading cause of cardiovascular diseases, stands as primary contributor to mortality among patients diagnosed with NAFLD. However, precise etiology by which NAFLD causes AS remains unclear. Exosomes are nanoscale extracellular vesicles secreted cells, and considered participate in complex biological processes promoting cell-to-cell organ-to-organ communications. As...
Human epidermal growth factor receptor 2 (HER2)-mutant lung cancer remains an orphan of specific targeted therapy. The variable responses to anti-HER2 therapies in these patients prompt us examine impact HER2 variants and co-mutations on treatments cancer.Patients with stage IV/recurrent HER2-mutant cancers identified through next-generation sequencings were recruited from seven hospitals. study comprised a cohort A establish the patterns B assess associations between variants, co-mutations,...
As an effective anticancer drug, the clinical limitation of doxorubicin (Dox) is time- and dose-dependent cardiotoxicity. Yes-associated protein 1 (YAP1) interacts with transcription factor TEA domain (TEAD1) plays important role in cell proliferation survival. However, YAP1 Dox-induced cardiomyopathy has not been reported. In this study, expression was reduced human failing hearts dilated vivo vitro cardiotoxic model. Ectopic Yap1 significantly blocked cardiomyocytes apoptosis TEAD1...