A5016456430- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Vibrio bacteria research studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Aquaculture Nutrition and Growth
- Cardiac pacing and defibrillation studies
Qingdao University
2014-2024
Affiliated Hospital of Qingdao University
2013-2024
Wenzhou Medical University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Ruijin Hospital
2014-2023
Shanghai Jiao Tong University
2014-2023
Shandong University
2022-2023
Jimei University
2019-2022
Abstract MicroRNA (miRNA) and long non-coding RNA (lncRNA) have been demonstrated to participate in the progression of many cancers. Hepatocellular carcinoma (HCC) is one most common aggressive malignant tumors worldwide, while molecular mechanisms underlying HCC tumorigenesis are not completely clear. In this study, we showed that miR-92b was significantly upregulated tumor tissue plasma patients, its expression level highly correlated with gender microvascular invasion. Functionally, could...
Abstract Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tissues and matched blood specimens over 10,000 in China by using 450-gene assay, developed implemented under international clinical regulations. We comparison somatically altered genes, distribution mutational burden (TMB), gene fusion patterns,...
We examined the assembly of amine-rich polysaccharide chitosan from solution onto electrode surfaces as a result voltage bias on electrode. Chitosan is positively charged and water soluble under mildly acidic conditions uncharged insoluble basic conditions. observed that deposited surface negative thickness layer order micron. The was to be dependent upon deposition time, applied voltage, concentration. No positive or an "electrode" had no voltage. Once neutralized, can retained without need...
Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation mortality among patients with enrolled the ASIAN ‐HF (Asian Sudden Cardiac Death Heart Failure) registry separate analyses for those reduced ejection fraction EF ; <40%) versus preserved (≥50%). Methods and Results The ‐ is a prospective longitudinal study. Participants symptomatic were recruited from 46 secondary care centers 3 Asian regions: South (India), Southeast...
Abstract The enzyme tyrosinase was used for the in vitro conjugation of protein gelatin to polysaccharide chitosan. Tyrosinases are oxidative enzymes that convert accessible tyrosine residues proteins into reactive o ‐quinone moieties. Spectrophotometric and dissolved oxygen studies indicate can oxidize we estimate 1 5 chains undergo reaction. Oxidized tyrosyl (i.e., quinone residues) nonenzymatic reactions with available nucleophiles such as nucleophilic amino groups Ultraviolet/visible,...
Background: Long non-coding RNA differentiation antagonizing non-protein coding (DANCR) is considered to be an oncogene in many cancer types. However, the role of DANCR diagnosis and progression hepatocellular carcinoma (HCC) still unknown. Patients Methods: In this study, 146 participants including healthy volunteers (HVs) patients with chronic hepatitis B (CHB), cirrhosis HCC were recruited. Results: Firstly, quantitative reverse transcription-PCR analysis showed that was up-regulated...
Background/Aims: Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor-specific stem cell marker in pancreatic cancer (PC). MicroRNA-195 (miR-195) plays an important role many types of tumors. However, the roles DCLK1 and miRNAs that directly regulate have not been elucidated. The goal this study to assess effects miR-195 on inhibiting clarify regulating mechanism miR-195-DCLK1 PC cells. Methods: expression protein tissues adjacent healthy was detected by Western blot quantitative...
A protein's functional properties can be adjusted by conjugating it to other polymers. We used a nature-inspired route create protein−polysaccharide conjugate and examined the of this conjugate. Specifically, enzyme tyrosinase was oxidize accessible tyrosine residues model protein green fluorescent (GFP). Oxidation yields quinone that are "activated" for covalent conjugation GFP nucleophilic groups aminopolysaccharide chitosan. Conjugation chitosan conferred distinct GFP. The GFP−chitosan...
Nanoscale particles offer a variety of interesting properties, and there is growing interest in their assembly into higher ordered structures. We report that the pH-responsive aminopolysaccharide chitosan can mediate electrodeposition model nanoparticles. Chitosan known to electrodeposit at cathode surface response high localized pH. To demonstrate nanoparticle deposition, we suspended fluorescently labeled latex nanoparticles (100 nm diameter spheres) solution (1%) performed (0.05 mA/cm2...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy closely related to metabolic reprogramming. We investigated how CTNNB1 mutation regulates the HCC phenotype and thus affects prognosis of HCC. obtained mRNA expression profiles clinicopathological data from The Cancer Genome Atlas (TCGA), International Genomics Consortium (ICGC) Gene Expression Omnibus database (GSE14520 GSE116174). conducted gene set enrichment analysis on patients with without mutant through TCGA dataset....
Background: Due to the heterogeneity of tumors and complexity immune microenvironment, specific role ferroptosis pyroptosis in hepatocellular carcinoma (HCC) is not fully understood, especially its impact on prognosis. Methods: The training set (n = 609, merged by TCGA GSE14520) was clustered into three subtypes (C1, C2, C3) based prognosis-related genes associated with pyroptosis. intersecting differentially expressed (DEGs) among C1, C3 were used univariate Cox LASSO penalized regression...
Hepatocellular carcinoma (HCC) is one of the most common causes cancer worldwide. Although many studies have focused on oncogene characteristics, genomic landscape Chinese HCC patients has not been fully clarified.A total 165 patients, including 146 males and 19 females, were enrolled. The median age was 55 years (range, 27-78 years). Corresponding clinical pathological information collected for further analysis. A 168 tumor tissues from these selected next-generation sequencing (NGS)-based...
Abstract The potential of an in situ gel‐forming adhesive was examined as a hemostatic surgical sealant. mechanism for this mimics the last stages blood coagulation but uses nonblood proteins. Specifically, gelatin is used structural protein and calcium‐independent microbial transglutaminase (mTG) crosslinking enzyme. In vitro burst pressure tests with porcine skin demonstrate that gelatin‐mTG forms gel within 30 min under moist conditions can restrain pressures 200 mmHg. vivo rat liver...
AIM:To evaluate the clinical value of serum CA19-9 levels in predicting respectability pancreatic carcinoma according to receiver operating characteristic (ROC) curve analysis.METHODS: Serum were measured 104 patients with cancer which possible be resected imaging.ROC was plotted for levels.The point closest upper left-hand corner graph chosen as cut-off point.The sensitivity, specificity, positive and negative predictive values at this calculated.RESULTS: Resectable detected 58 (55.77%)...
Abstract Hepatocellular carcinoma (HCC) is a malignant tumor and threatens human life worldwide, whereas the etiology pathogenesis of HCC have not been fully determined. In past few years, many microRNAs (miRNAs) proved to important roles in tumorigenesis HCC. this study, we found that miR-23b was significantly upregulated tissues patients. Functional tests showed could promote cell proliferation metastasis vitro vivo . Then, mechanistic investigations suggested ST7L direct target involved...
Background: miRNAs have been found to be dysregulated in cervical cancer. The dysregulation of miRNA has implicated carcinogenesis and progression. Therefore, further studies the specific roles deregulated cancer underlying molecular mechanisms may facilitate identification novel therapeutic techniques for patients with this disease. miRNA-641 (miR-641) was previously reported serve an important role lung However, expression pattern miR-641 remain unclear. Method: In study, level tissues...
Tumor mutation burden (TMB) is an emerging biomarker for immunotherapy of hepatocellular carcinoma (HCC), but its value clinical application has not been fully revealed.We used the Wilcox test to identify differentially expressed immune-related genes (DEIRGs) in groups with high and low TMB as well screened immune gene pairs related prognosis using univariate Cox regression analysis. A LASSO prognostic model was developed by combining The Cancer Genome Atlas Liver Hepatocellular Carcinoma...
Phenol reaction cascades are commonly used in nature to create crosslinked materials that perform mechanical functions. These processes mimicked by electrochemically initiating a cascade examine if the properties of biopolymer film can be predictably altered. Specifically, thin films (≈ 30–45 μm) polysaccharide chitosan cast onto gold-coated silicon wafers, chitosan-coated wafers immersed catechol-containing solutions, and phenol is anodically oxidized. The product this oxidation highly...
Long noncoding ribonucleic acid (lncRNA) X-inactive-specific transcript (Xist) was reported to affect cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, there are rare reports focusing on the diagnostic evaluation regulatory mechanism of Xist expression from peripheral blood cells patients with HCC.In this study, a cohort 206 female participants including healthy volunteers (HVs) chronic hepatitis B (CHB), cirrhosis HCC recruited. Coculture system used evaluate...