A5070802936- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Pericarditis and Cardiac Tamponade
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Cardiac tumors and thrombi
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Potassium and Related Disorders
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cerebrovascular and Carotid Artery Diseases
- Retinal Imaging and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
National University Heart Centre Singapore
2016-2025
National University of Singapore
2016-2025
National University Health System
2015-2025
University Health System
2025
Singapore Clinical Research Institute
2013-2024
The Alfred Hospital
2012-2024
Baker Heart and Diabetes Institute
2024
The University of Melbourne
2024
National University Hospital
1993-2024
Taipei Veterans General Hospital
2023-2024
Mitral regurgitation due to flail leaflet is difficult manage, because it frequently asymptomatic yet carries a high risk of left ventricular dysfunction and the natural history condition poorly defined.We obtained clinical follow-up data through 1994-1995 in 229 patients with isolated mitral leaflet; this was first diagnosed by echocardiography between 1980 1989.The 86 who were treated medically had mortality rate significantly higher than expected (6.3 percent yearly, P=0.016 for...
Background —The clinical spectrum of constrictive pericarditis (CP) has been affected by a change in incidence etiological factors. We sought to determine the impact these changes on outcome pericardiectomy. Methods and Results contemporary CP 135 patients (76% male) evaluated at Mayo Clinic from 1985 1995 was compared with that historic cohort. Notable trends were an increasing frequency due cardiac surgery mediastinal radiation presentation older (median age, 61 versus 45 years)....
The aim of these experiments was to evaluate the significance chemical reaction between hydrogen sulphide (H2S) and nitric oxide (NO) for control vascular tone.The effect sodium hydrosulphide (NaHS; H2S donor) a range NO donors, such as nitroprusside (SNP), either alone or together, determined using phenylephrine (PE)-precontracted rat aortic rings on blood pressure anaesthetised rats.Mixing NaHS with donors inhibited vasorelaxant both in vitro vivo. Low concentrations gas solution reversed...
Constrictive pericarditis is a potentially reversible cause of heart failure that may be difficult to differentiate from restrictive myocardial disease and severe tricuspid regurgitation. Echocardiography provides an important opportunity evaluate for constrictive pericarditis, definite diagnostic criteria are needed.Patients with surgically confirmed (n=130) at Mayo Clinic (2008-2010) were compared patients (n=36) diagnosed or regurgitation after was considered but ruled out. Comprehensive...
Whether prevalence and mortality of patients with heart failure preserved or mid-range (40–49%) ejection fraction (HFpEF HFmREF) are similar to those reduced (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined compared characteristics outcomes for HFpEF, HFmREF, HFrEF a prospective, international, multi-ethnic population. Prospective multi-centre longitudinal study New Zealand (NZ) Singapore. Patients HF were assessed at baseline followed over 2...
Background The optimal timing for surgery in patients with mitral regurgitation is disputed. Because of the frequency left ventricular dysfunction, which difficult to predict, early has been recommended, but its potential benefits have not demonstrated. Methods and Results outcomes 221 (mean age, 65±13 years; 71% males) flail leaflets diagnosed two-dimensional echocardiography between 1980 1989 who were eligible operation analyzed. Group I comprised 63 had valve (within 1 month after...
To characterize regional and ethnic differences in heart failure (HF) across Asia.We prospectively studied 5276 patients with stable HF reduced ejection fraction (≤40%) from 11 Asian regions (China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand). Mean age was 59.6 ± 13.1 years, 78.2% were men, mean body mass index 24.9 5.1 kg/m2. Majority (64%) of had two or more comorbid conditions such as hypertension (51.9%), coronary artery disease (CAD,...
Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation mortality among patients with enrolled the ASIAN ‐HF (Asian Sudden Cardiac Death Heart Failure) registry separate analyses for those reduced ejection fraction EF ; <40%) versus preserved (≥50%). Methods and Results The ‐ is a prospective longitudinal study. Participants symptomatic were recruited from 46 secondary care centers 3 Asian regions: South (India), Southeast...
Background Diabetes mellitus frequently coexists with heart failure ( HF ), but few studies have compared the associations between diabetes and cardiac remodeling, quality of life, clinical outcomes, according to phenotype. Methods Results We echocardiographic parameters, life (assessed by Kansas City Cardiomyopathy Questionnaire), outcomes (1‐year all‐cause mortality, cardiovascular hospitalization) patients without type 2 in prospective ASIAN ‐ (Asian Sudden Cardiac Death Heart Failure)...
Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, scarce Asia and have only utilised traditional classification of body mass index (BMI). We aimed investigate association between obesity (defined by BMI abdominal measures) HF outcomes Asia.Utilising Asian Sudden Cardiac Death Heart Failure (ASIAN-HF) registry (11 regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia,...
Heart failure (HF) is the most common long-term complication of acute myocardial infarction (MI). Understanding plasma proteins associated with post-MI HF and their gene expression may identify new candidates for biomarker drug target discovery.We used aptamer-based affinity-capture proteomics to measure 1305 at 1 month in a New Zealand cohort (CDCS [Coronary Disease Cohort Study]) including 181 patients who were subsequently hospitalized comparison 250 remained event free over median...