A5054990019- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- South Asian Studies and Conflicts
- Social and Economic Development in India
- Diabetes Treatment and Management
- Agricultural Economics and Practices
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Indian and Buddhist Studies
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Asian Geopolitics and Ethnography
- Cardiac Valve Diseases and Treatments
- Rangeland Management and Livestock Ecology
- Cardiac electrophysiology and arrhythmias
- Health and Medical Research Impacts
- Diet, Metabolism, and Disease
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
National Heart Centre Singapore
2018-2024
Duke-NUS Medical School
2021-2024
National University of Singapore
2012-2024
National University Heart Centre Singapore
2024
Monash Health
2023
Guntur Medical College
2023
University of Health Sciences
2023
University of Health Science
2023
SingHealth Duke-NUS Academic Medical Centre
2023
Australian Centre for Heart Health
2023
Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, scarce Asia and have only utilised traditional classification of body mass index (BMI). We aimed investigate association between obesity (defined by BMI abdominal measures) HF outcomes Asia.Utilising Asian Sudden Cardiac Death Heart Failure (ASIAN-HF) registry (11 regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia,...
Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is associated with adverse cardiac remodeling in the general population. Little about how nutritional status modifies relationship between obesity outcomes. We aimed to investigate association of clinical characteristics, echocardiographic changes, outcomes community.We examined 5,300 consecutive asymptomatic Asian participants who were prospectively recruited health screening program (mean age 49.6 ± 11.4 years,...
We investigated the prevalence, clinical characteristics, and prognosis of patients with heart failure (HF) improved ejection fraction (HFimpEF).
Abstract Background Increasing patient loads, healthcare inflation and ageing population have put pressure on the system. Artificial intelligence machine learning innovations can aid in task shifting to help systems remain efficient cost effective. To gain an understanding of patients’ acceptance toward such with AI, this study adapted Unified Theory Acceptance Use Technology 2 (UTAUT2), looking at performance effort expectancy, facilitating conditions, social influence, hedonic motivation...
Microvascular complications are common among patients with diabetes mellitus (DM). The presence of heart failure (HF) is presumed to be due macrovascular disease (typically HF reduced ejection fraction [HFrEF] following myocardial infarction). We hypothesized that preserved (HFpEF) in DM may a manifestation microvascular compared HFrEF. objective this study was examine the prevalence and association clinical outcome DM.We investigated prevalence, outcome, cardiac structure function...
Little information is available on sex differences in coronary microvascular dysfunction (CMD) heart failure with preserved ejection fraction (HFpEF). We investigated sex-specific proteomic profiles associated CMD patients HFpEF.
The increasing prevalence of heart failure (HF) in ageing populations drives demand for echocardiography (echo). There is a worldwide shortage trained sonographers and long waiting times expert echo. We hypothesised that artificial intelligence (AI)-enhanced point-of-care echo can enable HF screening by novices. primary endpoint was the accuracy AI-enhanced novice pathway detecting reduced LV ejection fraction (LVEF) < 50%. Symptomatic patients with suspected (N = 100, mean age 61 ± 15...
BACKGROUND Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is associated with adverse cardiac remodeling in the general population. Little about how nutritional status modifies relationship between obesity outcomes. We aimed to investigate association of clinical characteristics, echocardiographic changes, outcomes community. METHODS AND FINDINGS examined 5,300 consecutive asymptomatic Asian participants who were prospectively recruited health screening...
Individuals with type 2 diabetes mellitus (DM) have an increased risk of pneumonia and septic shock. Traditional glucose-lowering drugs recently been found to be associated a higher infections. It remains unclear whether sodium-glucose cotransporter inhibitors (SGLT2is), which pleiotropic/anti-inflammatory effects, may reduce the shock in DM.
A lack of geographic and racial diversity in clinical trial populations may arise from a disproportionate focus on the United States Europe for leadership conduct. Inadequate compromise external validity to Asia-Pacific (APAC) region, where 60% global cardiometabolic disease exists. This study aimed assess proportion trends Asian race participants APAC authorship trials. We performed systematic review all cardiovascular, diabetes obesity-related randomized controlled trials (phase ≥2, n =...
Background Among the growing numbers of patients with heart failure, up to one half have failure preserved ejection fraction ( HF p EF ). The lack effective treatments for is a substantial and escalating unmet clinical need—and ‐specific animal models represents major preclinical barrier in advancing understanding . As established reduced r ) proven ineffective , contention that intrinsic cardiomyocyte phenotype distinct these 2 conditions requires consideration. Our goal was validate...
Abstract Background Heart failure (HF) and diabetes are associated with increased incidence worse prognosis of each other. The prognostic value global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been established in HF patients diabetes. Methods In this prospective, observational study, consecutive ( n = 315) underwent CMR at 3T, including GLS, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV) mapping. Plasma biomarker...
The relationship of serial NT-proBNP (N-terminal pro-B-type natriuretic peptide) measurements with changes in cardiac features and outcomes heart failure (HF) remains incompletely understood. We determined whether common clinical covariates impact these relationships.