A5109590017- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Potassium and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Blood Pressure and Hypertension Studies
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Lymphatic System and Diseases
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
University of Hong Kong
2016-2025
Queen Mary Hospital
2016-2025
University of Hong Kong - Shenzhen Hospital
2016-2025
Chinese University of Hong Kong
2014-2025
Hong Kong University of Science and Technology
2021
Hong Kong College of Technology
2019
Castle Peak Hospital
2019
Fundación Juan March
2014
Tung Wah Hospital
2007-2014
Leiden University Medical Center
2011-2013
BackgroundChina has the largest burden of heart failure worldwide. However, large-scale studies on mortality are scarce. We aimed to investigate and identify risk factors for among patients with in China.MethodsThis prospective cohort study used data from China Cardiovascular Association (CCA) Database-Heart Failure Centre Registry, which were linked National Mortality Registration Information Management System by Chinese Disease Control Prevention. included enrolled Jan 1, 2017, Dec 31,...
Introduction: Emerging data have suggested that right ventricular (RV) apical pacing results in progressive left (LV) dysfunction and contributes to the development of heart failure (HF). This study aimed investigate prevalence clinical predictors for new‐onset HF after long‐term RV patients with acquired atrioventricular (AV) block who require permanent pacing. Methods: We studied outcomes AV 304 without a prior history HF. All had >90% as determined by device diagnostic data. Results:...
Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D circulating progenitor cells dysfunction in DM patients nonetheless remains unclear.We aimed to investigate the cross-sectional association status brachial flow-mediated dilation (FMD) cell (EPC) numbers patients.We conducted a study 280 (59% male, aged 68 ± 10 yr) recruited outpatient clinics during winter period.We measured serum 25-hydroxyvitamin [25(OH)D]...
Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients.A total 247 T2DM patients without history complications and participated CDATS were prospectively enrolled. Left ventricular (LV) systolic function assessed by LV ejection fraction speckle tracking derived GLS. Diastolic E/E' ratio defined as passive trans-mitral inflow velocity tissue...
This study investigated the prognosis of coronary microvascular disease (CMD) as determined by stress perfusion cardiac magnetic resonance (CMR) in patients with ischemic symptoms but without significant artery (CAD).Patients CMD have poorer various diseases. The myocardial reserve index (MPRI) derived from noninvasive CMR has been established to diagnose angina a threshold MPRI <1.4. is unknown.Chest pain epicardial CAD or January 2009 December 2017 were retrospectively included 3 imaging...
Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association statin use cancer and cancer-related mortality among patients HF are sparse.Using a previously validated territory-wide clinical information registry, was ascertained all eligible (n = 87 102) from 2003 2015. Inverse probability treatment weighting used balance baseline covariates between nonusers 50 926) users 36 176). Competing regression Cox proportional-hazard models performed...
BackgroundHeart failure (HF) and dementia frequently co-exist with shared pathological mechanisms risk factors. Our study aims to investigate the association between statin therapy risks of its subtypes among patients HF.MethodsThe Hong Kong Clinical Data Analysis Reporting System database was interrogated identify incident HF diagnosis from 2004 2018, using ICD 9/ICD 10 codes. Inverse probability treatment weighting (IPTW) used balance baseline covariates users (N = 54,004) non-users...
Endothelial injury is a common occurrence following stent implantation, often leading to complications such as restenosis and thrombosis. To address this issue, we have developed multi-functional coating that combines dopamine-copper (DA-Cu) base with therapeutic biomolecule modification, including nitric oxide (NO) precursor L-arginine, endothelial glycocalyx heparin, cell (EC) catcher vascular growth factor (VEGF). In our coating, the incorporated Cu acts sustainable catalyst for...
Background: We aim to investigate the effect of exercise training on endothelial function and capacity in patients with coronary artery disease. Methods results: A randomized, controlled trial was conducted determine effects an 8-week programme ( n = 32) vs. controls brachial flow-mediated dilation (FMD) stable CAD. After 8 weeks, received had significant improvements FMD (1.84%, p 0.002) (2.04 metabolic equivalents, < 0.001) compared controls. The change correlated inversely baseline r...
Patients with type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction and arterial stiffness. Levels circulating progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels EPCs stiffness unknown.We measured brachial-ankle pulse wave velocity (baPWV) 234 patients DM compared them 121 age- sex-matched controls.Patients had significantly lower Log CD34/KDR+ CD133/KDR+ EPC counts, higher baPWV controls (all P...
Amiodarone-induced thyrotoxicosis (AIT) is a clinical condition that notoriously difficult to manage; the relative risk of adverse cardiovascular events in these patients compared with euthyroid largely unknown.We characteristics and major (MACE) AIT patients.Patients at tertiary referral center who had been prescribed amiodarone for least 3 months were retrospectively analyzed. Baseline characteristics, laboratory parameters, outcome evaluated. MACE was defined as mortality, myocardial...
Background— Patients who undergo tricuspid annuloplasty during left-side heart valve surgery have a poor postoperative clinical outcome. However, preoperative right ventricular (RV) echocardiography parameters that predict adverse events in these patients are poorly understood. Methods and Results— We studied 74 (age, 58±10 years; men, 27%) with significant regurgitation consequently underwent surgery. A total of 26 (22 failures 4 cardiovascular deaths) occurred median follow-up months. RV...
The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score and the modified MELD with albumin replacing (MELD-Albumin) score, which reflect both liver renal function, have been reported as predictors of adverse events in heart disease. Nonetheless, their prognostic value patients undergoing tricuspid annuloplasty has not addressed.
The characteristics of infective endocarditis (IE) in Asians are poorly understood. Therefore, we aim to describe the epidemiological trends and clinical features IE Hong Kong.All patients with incident from 2002-2019 a territory-wide database Kong were identified. We studied age- sex-adjusted one-year mortality between 2002 2019 identified significant contributors 1-year all-cause death using attributable fraction. used propensity score inverse treatment weighting study association surgery...