A5100439203- Biosensors and Analytical Detection
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Immune Cell Function and Interaction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Tissue Engineering and Regenerative Medicine
- Venous Thromboembolism Diagnosis and Management
- Service-Oriented Architecture and Web Services
- Collaboration in agile enterprises
- Mobile Health and mHealth Applications
- Advanced Sensor and Energy Harvesting Materials
- SARS-CoV-2 and COVID-19 Research
- Biofield Effects and Biophysics
- Microfluidic and Capillary Electrophoresis Applications
- Inhalation and Respiratory Drug Delivery
- Cardiac tumors and thrombi
- Image Processing Techniques and Applications
- Data-Driven Disease Surveillance
- Blood Coagulation and Thrombosis Mechanisms
Sichuan University
2020-2025
Tianjin University of Science and Technology
2024
Henan Agricultural University
2024
Zhejiang University
2015-2023
Chengdu University
2022
West China Hospital of Sichuan University
2022
Georgetown University Medical Center
2021
Georgetown University
2021
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2016-2020
National Clinical Research Center for Digestive Diseases
2020
Infectious diseases such as HIV and hepatitis B pose an omnipresent threat to global health. Reliable, fast, accurate, sensitive platforms that can be deployed at the point-of-care (POC) in multiple settings, airports offices, for detection of infectious pathogens are essential management epidemics possible biological attacks. To best our knowledge, no viral load technology adaptable POC settings exists today due critical technical challenges. Here, we present first time a broadly applicable...
ABSTRACT Endothelial injury is a common occurrence following stent implantation, often leading to complications such as restenosis and thrombosis. To address this issue, we have developed multi‐functional coating that combines dopamine‐copper (DA‐Cu) base with therapeutic biomolecule modification, including nitric oxide (NO) precursor L‐arginine, endothelial glycocalyx heparin, cell (EC) catcher vascular growth factor (VEGF). In our coating, the incorporated Cu acts sustainable catalyst for...
Abstract Development of portable biosensors has broad applications in environmental monitoring, clinical diagnosis, public health, and homeland security. There is an unmet need for pathogen detection at the point‐of‐care (POC) using a fast, sensitive, inexpensive, easy‐to‐use method that does not require complex infrastructure well‐trained technicians. For instance, Human Immunodeficiency Virus (HIV‐1) acute infection stage been challenging, since current antibody‐based POC technologies are...
HIV has become one of the most devastating pathogens in human history. Despite fast progress HIV-related basic research, antiretroviral therapy (ART) remains effective method to save AIDS patients' lives. Unfortunately, ART cannot be universally accessed, especially developing countries, due lack treatment monitoring diagnostics. Here, we present an inexpensive, rapid and portable micro-a-fluidic platform, which can streamline process enzyme-linked immunosorbent assay (ELISA) a fully...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent develop inhalable vaccines, instead of injectable elicit mucosal immunity against viral infections. Methods We reported an hybrid nanovaccine (NV RBD -MLipo) boost protective SARS-CoV-2 infection. Nanovesicles derived from genetically engineered 293T cells expressing ) were fused pulmonary surfactant (PS)-biomimetic...
Significance Biosensing technologies have significant impact on medical diagnostics but difficulties in the handling of complex biospecimens, portability, and nonlinearity dynamic detection range present considerable technical bottlenecks their translation into clinical settings. Here, we nanoplasmonic electrical field-enhanced resonating device (NE 2 RD) that detects quantifies multiple biotargets from distinct specimens (i.e., saliva, serum, whole blood) with a broad linear range. Unlike...
Abstract Extracellular vesicles (EVs) derived from immune cells have shown great anti-cancer therapeutic potential. However, inefficiency in EV generation has considerably impeded the development of EV-based basic research and clinical translation. Here, we developed a seesaw-motion bioreactor (SMB) system by leveraging mechanical stimuli such as shear stress turbulence for generating EVs with high quality quantity natural killer (NK) cells. Compared to production traditional static culture...
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In cancer, persistent HPV infections induce E6 E7 oncoproteins, which promote cell proliferation carcinogenesis resulting elevated levels host antibodies (e.g., anti-HPV16 antibody). Currently, these are clinically diagnosed using invasive biopsy-based tests, performed only centralized labs by experienced clinical...
Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis difficult patients having because the lack diagnostic biomarkers. Tumour-derived exosomes play a crucial role tumour growth, metastasis, immune regulation, monitor disease development. Hence,we established RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), messenger (mRNA) plasma tumour-derived from four with cardiac myxoma-related ischaemic (CM-IS) six without (non-IS CM)....
Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the diagnosis of tuberculosis (TB) remains a major challenge. Here, we report simple low-cost microchip-based TB ELISA (MTBE) platform detection anti-mycobacterial IgG in plasma samples less than 15 minutes. The MTBE employs flow-less, magnet-actuated, bead-based simultaneous responses against multiple mycobacterial antigens. Anti-trehalose 6,6'-dimycolate (TDM) were strongest predictor...
The developed bioartificial liver support system integrated with the decellularized matrix/GelMA-based bioengineered whole can potentially help elevate functions and prevent hepatic encephalopathy <italic>via</italic> enhanced ammonia reduction.
The World Health Organization (WHO) is rapidly expanding antiretroviral treatment (ART) in sub-Saharan countries. However, virological failure of ART rarely monitored due to the lack affordable and sustainable viral load assays suitable for resource-limited settings. Here, we report a prototype rapid virus detection method based on microfluidic technologies. In this method, HIV-1 particles from 10 μL whole blood were captured by anti-gp120 antibody coated microchannel surface detected dual...