A5070694342- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Oral microbiology and periodontitis research
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Electrospun Nanofibers in Biomedical Applications
- Simulation and Modeling Applications
- Lymphatic System and Diseases
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Biomarkers in Disease Mechanisms
- Dental Health and Care Utilization
- Mesenchymal stem cell research
- Congenital heart defects research
- Gout, Hyperuricemia, Uric Acid
- Pluripotent Stem Cells Research
- Gastroesophageal reflux and treatments
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
University of Hong Kong
2014-2023
Tianjin University
2023
Queen Mary Hospital
2013-2022
University of Hong Kong - Shenzhen Hospital
2014-2022
Chinese University of Hong Kong
2013-2020
City University of Hong Kong, Shenzhen Research Institute
2020
First People's Hospital of Foshan
2019
Henan Normal University
2015
Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients.A total 247 T2DM patients without history complications and participated CDATS were prospectively enrolled. Left ventricular (LV) systolic function assessed by LV ejection fraction speckle tracking derived GLS. Diastolic E/E' ratio defined as passive trans-mitral inflow velocity tissue...
Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation human embryonic stem cell-derived cardiomyocytes (hESC-CMs) induced pluripotent mesenchymal cells (hiPSC-MSCs) in a porcine model HF.Eight weeks after induction HF with myocardial infarction (MI) rapid pacing, animals impaired left ventricular ejection fraction (LVEF) were randomly assigned receive injection saline (MI...
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating wide range disorders. Wireless powering could enable long-term operation these devices, but achieving high performance miniaturized and deeply placed remains technological challenge. We report the integration wireless system in soft neuromodulation device (15 mm length, 2.7 diameter) demonstrate (about 10%) during vivo stimulation vagus nerve porcine animal model. The increased enabled by...
Rationale: Poor survival and engraftment are major hurdles of stem cell therapy in the treatment myocardial infarction (MI).We sought to determine whether pre-transplantation systemic intravenous administration human induced pluripotent (hiPSC)-derived mesenchymal stromal cells (hiPSC-MSCs) could improve hiPSC-MSCs or hiPSC-derived cardiomyocytes (hiPSC-CMs) following direct intramyocardial transplantation a mouse model MI.Methods: Mice were randomized undergo saline 5×10 5 one week prior...
This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure preserved ejection fraction (HFpEF).We analysed HFpEF participants from Americas Treatment Preserved Cardiac Function Heart Failure an Aldosterone Antagonist (TOPCAT) trial available baseline data (n = 1747). Patients were grouped into hypochromia or non-hypochromia group according a MCHC cut-off level 330 g/L. Cox proportional hazard model...
Abstract Background The creation of a bioengineered cardiac patch (BCP) is potential novel strategy for myocardial repair. Nevertheless, the ideal scaffold BCP unknown. Objective We investigated whether decellularized placenta (DP) could serve as natural material to create Methods and results A was created by seeding human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs; 1 × 106/cm2) onto DP. functional electrophysiological properties were first characterized in vitro...
The aims of this study were to identify the prevalence vitamin D insufficiency in pregnant women Shanghai, China and determine correlations between 25-hydroxyvitamin (25(OH)D) age, serum lipids, renal function, BMI, gestational weeks, season sampling.A total 1695 who visited outpatient clinic for their first prenatal examination included study.Over 90.5% these had less than optimal levels 25(OH)D. Of women, 1162 deficient, 372 insufficient, only sufficient, 5 possible hypervitaminosis....
High-sensitivity cardiac troponin I(hs-TnI) and T levels(hs-TnT) are sensitive biomarkers of cardiomyocyte turnover or necrosis. Prior studies the predictive role hs-TnT in type 2 diabetes mellitus(T2DM) patients have yielded conflicting results. This study aimed to determine whether hs-TnI, which is detectable a higher proportion normal subjects than hsTnT, associated with major adverse cardiovascular event(MACE) T2DM patients. We compared hs-TnI level stored serum samples from 276...
A non-dipper pattern of high blood pressure is associated with increased risk organ damage and cardiovascular disease in patients hypertension. The aim the study was to evaluate left ventricular (LV) remodeling function arterial stiffness a dipper/non-dipper total 183 hypertensive no history adverse events were divided into two groups based on 24 hours ambulatory monitoring (ABPM): 66 dipper 117 pattern. Detailed transthoracic echocardiogram performed analyzed advance speckle tracking...
Abstract Obstructive sleep apnoea ( OSA ) characterized by intermittent hypoxia IH is closely associated with cardiovascular diseases. confers cardiac injury via accelerating cardiomyocyte apoptosis, whereas the underlying mechanism has remained largely enigmatic. This study aimed to explore potential mechanisms involved in ‐induced damage performed ‐exposed cell and animal models investigate protective effects of haemin, a potent haeme oxygenase‐1 HO ‐1) activator, on induced . Neonatal rat...
To evaluate left ventricular (LV) function and carotid intima-media thickness (IMT) in patients with axial SpA relationship to underlying disease severity.We recruited 104 50 controls. Detailed transthoracic echocardiography was performed analysed two-dimensional speckle tracking strain analysis for systolic tissue Doppler-derived E/E' diastolic assessment. Carotid IMT measured by ultrasonography subclinical atherosclerosis. Radiological severity of assessed the modified Stoke Ankylosing...
Abstract Background Periodontal disease closely links to various systemic diseases. This l8‐year retrospective cohort study investigated whether poor periodontal condition may increase the risk for onset of comorbidities. Methods A total 488 individual dental folders from 17 400 hospital attendees registered 1996 1998 were randomly selected, and these participants free diabetes, cardiovascular disease, chronic obstructive pulmonary cancer, stroke, cognitive impairment, hypertension,...
<title>Abstract</title> <bold>Background: </bold>Obesity and metabolic unhealth don’t always co-exist as the risk factors of heart failure (HF). Phenotypes derived from obesity have promising clinical relevance. Their predictive effect for different subtypes HF is to be investigated. <bold>Methods findings: </bold>Totally 8018 participants ARIC study were classified into four phenotypes: healthy non-obesity (MHNO), (MHO), unhealthy (MUNO) (MUO). Cox models applied explore relationship...
It remains debated whether pulse pressure is associated with left ventricular traits and adverse outcomes over beyond mean arterial (MAP) in patients heart failure (HF) preserved ejection fraction. We investigated these associations 3428 HF fraction (51.5% women; age, 68.6 years) enrolled the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist). computed association sizes hazards ratios 1-SD increase MAP pressure. In multivariable-adjusted...
The prognostic significance of blood urea nitrogen (BUN)/creatinine ratio specifically in chronic heart failure with preserved ejection fraction (HFpEF) patients remained unclear. We aimed to evaluate the association BUN/creatinine (baseline level and visit-to-visit variation) risk adverse clinical outcomes among HFpEF.This is a secondary analysis Treatment Preserved Cardiac Function Heart Failure an Aldosterone Antagonist (TOPCAT) trial. Of enrolled 3445 participants TOPCAT trial,...
The strong relationship between cigarette smoking and cardiovascular disease (CVD) has been well-documented, but the mechanisms by which increases CVD risk appear to be multifactorial incompletely understood. Mesenchymal stem cells (MSCs) are regarded as an important candidate for cell-based therapy in CVD. We hypothesized that MSCs derived from induced pluripotent cell (iPSC-MSCs) or bone marrow (BM-MSCs) might alleviate smoke (CS)-induced cardiac injury. This study aimed investigate...
Abstract Background Periodontitis significantly increases the risk of diabetic complications. This clinical trial investigated effects periodontal therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and periodontitis. Materials methods Fifty‐eight subjects T2DM periodontitis were randomly allocated to Treatment Group ( n = 29) receiving non‐surgical therapy, Control having only oral hygiene instructions delayed treatment until completion this 6‐month study. The left...
Background The optimal salt restriction in patients with heart failure (HF), especially preserved ejection fraction (HFpEF), remains controversial. Objective To investigate the associations of cooking risks clinical outcomes HFpEF. Methods Cox proportional hazards model and subdistribution were used this secondary analysis 1713 participants HFpEF from Americas TOPCAT trial. Cooking score was sum self-reported added during homemade food preparation. primary endpoint a composite cardiovascular...